The effect of BisGMA on cyclooxygenase-2 expression, PGE2 production and cytotoxicity via reactive oxygen species- and MEK/ERK-dependent and -independent pathways

The cytotoxicity of methacryloxylethyl cetyl ammonium chloride, a cationic antibacterial monomer, is related to oxidative stress and the intrinsic mitochondrial apoptotic pathway

“…Recent invetigations have indicated that the disturbance of cellular redox balance is involved in dental monomer-related cytotoxicity (14)(15)(16)(17). However, to our knowledge, no report concerning the involvement of ROS overproduction in antibacterial monomer-related cytotoxicity has been published.…”

Cytotoxic effects of bulk fill composite resins on human dental pulp stem cells

“…Although the mechanisms of this cytotoxicity and apoptosis were not completely explained, recent studies have concentrated on reactive oxygen species (ROS) and glutathione depletion (18,35,36). ROS are defined as molecules that destabilize cellular redox equilibrium, leading to apoptosis-induced cell death (18).…”

The role of reactive oxygen species and hemeoxygenase-1 expression in the cytotoxicity, cell cycle alteration and apoptosis of dental pulp cells induced by BisGMA

“…Viable cell numbers were estimated by MTT assay [9,10]. Briefly, 2.5 Â 10 5 of pulp cells were seeded onto 6-well culture plates.…”

“…By the approval of Ethics Committee, National Taiwan University Hospital, dental pulp tissues were obtained during extraction of third molars or premolars from young healthy donors in the Oral Surgery Clinics by the informed consent of the patients. Dental pulp cells were cultured by a tissue explant technique as described previously [9,10].…”