The Effect of Bitter Melon (Momordica charantia L.) Leaves Extract on TNF-α Serum Levels and Diabetic Foot Ulcers Improvement : Randomized Controlled Trial

Rosyid, Fahrun Nur; Dharmana, Edi; Suwondo, Ari; Sugiarto, _

doi:10.13005/bpj/1505

Cited by 14 publications

(17 citation statements)

References 41 publications

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“…The majority of respondents in the treatment and control groups were women. This study is in accordance with the research by Rosyid et al [22], which states that the prevalence of diabetes mellitus is higher in women because women have a greater chance of increasing body mass index than men. This is caused by hormonal conditions such as pre-menstruation syndrome and postmenopausal conditions so that the distribution of body fat easily accumulates [23].…”

Section: Characteristics Of Respondents In Diabetes Mellitus Patientssupporting

confidence: 93%

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2021

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This study aimed to determine the effect of video education about hypoglycemia on knowledge of diabetes mellitus patients and their families. This type of research is a quantitative study with a pre-experiment method. This study focused on two groups, namely, type 2 diabetes mellitus patients by 162 people, and the families of diabetes mellitus patients by 162 people. In the group of diabetes mellitus patients, the sample used 30 respondents who were divided into two groups, namely 15 respondents in the experimental group and 15 respondents in the control group. In the population of family diabetes mellitus patients, the sample applied 30 respondents, who were divided into 15 respondents for the experimental group and 15 respondents for the control group. Non-probability sampling with a purposive sampling technique was utilized. Data analysis using the paired t-test showed a p-value of 0.001 <0.05. So, it can be concluded that health education on knowledge of hypoglycemia in type 2 diabetes mellitus patients was effective in the working area of Puskesmas Nguter Sukoharjo. For the results of the paired t-test, we found p = <0.001 in the experimental group, which showed that there was an effect of hypoglycemia health education with videos on knowledge of type 2 diabetes families. Diabetes mellitus patients need to always adopt a healthy lifestyle so as to create a good health status and avoid complications of diabetes mellitus patients.

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Section: Characteristics Of Respondents In Diabetes Mellitus Patientssupporting

confidence: 93%

Untitled

2021

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“…For the domain “outcome measurement”, nine studies were unclear with regard to AE. These were consistently tracked or only reported occasionally (Dans et al, 2007; John et al, 2003; Kim et al, 2020; Kumari et al, 2018; Lim et al, 2010; Rahman et al, 2015; Rosyid et al, 2018; Suthar_b et al, 2016; Zänker et al, 2012).…”

Section: Resultsmentioning

confidence: 97%

“…All seven studies administered anti-diabetic medication as co-intervention. In one of these studies participants used also antibiotics (Rosyid et al, 2018). The IRR was calculated for each study, ranging from 0.33 (95% CI = 0.01 to 16.54) to 13 (95% CI = 0.73 to 230.76) for AE.…”

Section: Resultsmentioning

confidence: 99%

“…When multiple intervention groups from one study were in a meta-analysis, we combined the groups to create a single pair-wise comparison. We established a cut-off value of 3g per day of MC to analyse as a separate group because most AE were seen in trials with a daily dose of > 3g MC per day (Cortez-Navarrete et al,2018; Rosyid et al, 2018; Soo May et al, 2018).…”

Section: Methodsmentioning

confidence: 99%

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Possible harms ofMomordica charantia L. in humans; a systematic review

Demmers¹,

Mes

Elbers³

et al. 2022

Preprint

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IntroductionA few cases of serious side effects have been reported of Momordica charantia L. (MC). No comprehensive safety assessment has yet been performed based on human intake.This systematic review aims to evaluate the potential harm of Momordica charantia L. derived products using data from randomized controlled trials.MethodsDatabases Cochrane Library, Pubmed and EMBASE were searched until December 2020. The PRISMA harms checklist was followed. Data extraction was on aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, adverse effects (AE), reasons for drop out related to the intervention and interaction with other treatment. Two authors independently extracted data and bias was evaluated based on the latest version of the Cochrane risk of Bias Tool (RoB 2). Additional safety data were requested from Health Regulatory Agencies, Herbal Medicine Associations and manufacturers.ResultsSeventeen trials met the inclusion criteria. The IRR was calculated for each study ranging from 0.30 (95% CI = 0.12 to 0.75) to 13.00 (95% CI = 0.73 to 230.76) of any adverse events.ConclusionsUnder a daily dosage of 6g of MC-derived products no evidence was seen of harms in humans. In case reports that showed serious harm, MC was used in a liquid form. The safety of traditional MC-based supplements appears more guaranteed when produced under strict quality standards.

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“…Oxidative stress, known to be caused by excessive oxidants, is very important in wound healing because it causes further damage to tissues and therefore reduces or delays the healing process. It has been reported in the literature that the analgesic and antiinflammatory activities of bitter melon accelerate capillary circulation, thereby increasing oxygenation, which is an important factor in wound healing, and that the antiinflammatory and antioxidant activities reduce the harm caused by free radicals formed as a result of the inflammation and prevent the progression of necrosis (Kumar and Bhowmik, 2010;Agyare et al, 2014;Aljohi et al, 2016;Rosyid et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of bitter melon extract in the treatment of ischemic wounds in rats

Kısacık¹,

Güneş²,

Yaprakci³

et al. 2018

Turk J Biol

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There is no consensus on the properties of an ideal dressing for treating wounds. The aim of this study was to investigate the efficacy of dressings using topically administered bitter melon extract with olive oil, pure olive oil, nitrofurazone, and saline in the healing of ischemic wounds. A sample group of 48 rats was used in the trial. Their wounds were treated with bitter melon extract, pure olive oil, nitrofurazone, and saline. Data were collected between October 2014 and April 2015. The highest percentage (94.7%) of wound healing was observed in the bitter melon extract group and the lowest percentage (86.3%) in the nitrofurazone group. At the end of the 21st day, macroscopic reepithelialization was observed in 9 wounds in the bitter melon extract group (75%), in 6 wounds in the pure olive oil group (50%), and in only 3 wounds in the nitrofurazone and saline groups (25%). It can be concluded that dressing with a bitter melon extract is more efficient in the treatment of wounds than using nitrofurazone or saline, and that dressing with olive oil accelerates wound healing, although not as much as dressing with bitter melon extract.

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The Effect of Bitter Melon (Momordica charantia L.) Leaves Extract on TNF-α Serum Levels and Diabetic Foot Ulcers Improvement : Randomized Controlled Trial

Cited by 14 publications

References 41 publications

Untitled

Untitled

Possible harms ofMomordica charantia L. in humans; a systematic review

Effectiveness of bitter melon extract in the treatment of ischemic wounds in rats

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