2014
DOI: 10.1136/openhrt-2014-000087
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The effect of bivalirudin and closure device on bleeding outcomes after percutaneous coronary interventions

Abstract: IntroductionStudies have demonstrated bivalirudin efficacy in some patients at increased risk of bleeding. The aim of this study was to determine the extent to which bleeding reduction is achieved among all patients using bivalirudin as compared with a heparin with or without 2B3A inhibitor strategy.MethodsThis is a real-world, large-scale retrospective study utilising the American College of Cardiology (ACC) data from a 37-hospital Ascension Health System. The registry represents routine clinical practice bet… Show more

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Cited by 2 publications
(1 citation statement)
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“…The bleeding risk tool was designed for an era of higher dose heparin before bivalirudin was a consideration. Because bivalirudin greatly decreases of the risk of bleeding for all patients regardless of bleeding risk, 20 it is not surprising that the tool's discrimination capability would not be applicable. 21 22 As expected, the predictive accuracy of the BRS was poor because bleeding rates among patients given bivalirudin are so low (1.5% or less).…”
Section: Discussionmentioning
confidence: 99%
“…The bleeding risk tool was designed for an era of higher dose heparin before bivalirudin was a consideration. Because bivalirudin greatly decreases of the risk of bleeding for all patients regardless of bleeding risk, 20 it is not surprising that the tool's discrimination capability would not be applicable. 21 22 As expected, the predictive accuracy of the BRS was poor because bleeding rates among patients given bivalirudin are so low (1.5% or less).…”
Section: Discussionmentioning
confidence: 99%