The effect of blunt trauma on the ultrastructure of ratellar chondrocytes in rabbit articular cartilage a light and electron microscopic study

Katsorchis, Th.; Kalogeromitros, D.; Makridimitri, A.

doi:10.1016/0309-1651(91)90109-v

Cited by 1 publication

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“…Chondrocyte function can be altered by several intrinsic and external factors such as radiation, drugs and trauma. Chondrocytes have repairing mechanisms that can lead to restoration of normal cell function, to degeneration or to total alteration (metaplasia) [18]. In this study, the evaluation of the specimens showed significant structural and functional differences among the chondrocytes.…”

Section: Discussionmentioning

confidence: 55%

Articular changes in experimentally induced patellar trauma

Triantafillopoulos¹,

Papagelopoulos²,

Politi

et al. 2001

Knee, Surg, Sports Traumatol, Arthrosc

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Only a few studies have described the microscopic pathology of the articular cartilage after trauma. In the present animal study, we demonstrate the effect of trauma on the articular cartilage of the patella and determine the histological changes. Traumatic injury of the patella was experimentally induced in 45 white New Zealand rabbits aged 4 to 6 months old. The articular cartilage of the patella was observed after the sacrifice of the animals immediately and at days 1, 2, 4, 8, and 15 as well as at months 1, 2 and 3 after the traumatic injury. Macroscopic, light and electron microscopic findings showed progressive articular cartilage changes with failed effort of cartilage repair. Osteoarthritic-like degeneration of the articular cartilage was found in all specimens. According to this experimental study, trauma to the articular cartilage may progress to arthritis. The reversibility of cartilage damage or the progression to arthritis seem to be associated with many factors such as the intensity and frequency of the trauma, the mechanism of injury, the intrinsic remodeling of the cartilage matrix and the capability of the articular cartilage to regenerate.

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Section: Discussionmentioning

confidence: 55%