The Effect of Body Weight Gain with or Without Diabetes Type 2 on the Levels of Noradrenalin and Some Neurotrophins

Abstract

This work aimed to study the effect of body weight gain in individuals with or without diabetes mellitus Type 2 (DMT2) on the nervous system. Seventy-five subjects participated in this study, including 25 obese patients with DMT2 (BMI≥30kg/m2), 25 obese individuals without diabetes (BMI≥30kg/m2) and normal-weight healthy (BMI˂25kg/m2). In addition to body mass index (BMI), the west/hip ratio (WHR) and total body fat (TBF%) were calculated. 10ml of blood was collected from participants and used to determine the levels of HbA1C, noradrenaline (NA), brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and fasting blood glucose (FBG). The level of NGF increased while BDNF and NA levels decreased in obese with and without diabetes compared to control. Interestingly, BDNF level was significantly higher in the obese with diabetes than without. Moreover, TBF% and WHR values were significantly higher in the obese with diabetes when compared with those without diabetes. At the same time, there were no significant differences between BMI value in these two groups. BMI, TBF% and WHR significantly correlate with FBG, HbA1C and NGF and negative significant correlation with BDNFdoes not correlate; only WHR has no correlationdoes and does not correlate with NA. As well as, HbA1C has a significant correlation with the nerve markers, positive with BDNF and NGF and negative with NA, while FBG did not correlate with them. In conclusion, neurotransmitters and neurotrophin levels could use as risk factors for diabetes, and obesity could be considered as a risk factor for neuropathy as much as diabetes.