The Effect of Bolus Vitamin D3 Supplementation on Distal Radius Fracture Healing: A Randomized Controlled Trial Using HR-pQCT

Heyer, Frans; Jong, Joost J.A. de; Willems, Paul; Arts, Jacobus J.; Bours, S.; Kuijk, Sander M J van; Bons, J; Poeze, Martijn; Geusens, Piet; Rietbergen, B. van; Bergh, J.P. van den

doi:10.1002/jbmr.4311

Cited by 14 publications

(11 citation statements)

References 52 publications

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“…A controlled study however could not demonstrate a radiological advantage of vitamin D supplementation for elderly subjects with vertebral fractures [27]. In line with these data, a new small-scale study showed no effect on bone characteristics after a low bolus dose of vitamin D, whereas a higher dose suggested even a negative effect on bone mineral density or strength [28]. Therefore, it is plausible that severe vitamin D deficiency could impair optimal bone mineralization of a healing fracture, but there is no consensus about the benefits of vitamin D for fracture healing in patients with modest vitamin D status.…”

Section: Consequences Of Vitamin D or Calcifediol Deficiency Musculos...mentioning

confidence: 84%

Calcifediol (25OH Vitamin D3) Deficiency: A Risk Factor from Early to Old Age

Bouillon

LʼAbbate

Rosero³

2022

Nutrients

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Vitamin D deficiency is the main cause of nutritional rickets in children and osteomalacia in adults. There is consensus that nutritional access to vitamin D can be estimated by measuring serum concentrations of 25OHD and vitamin D deficiency can thus be considered as calcifediol deficiency. However, the threshold for vitamin D/calcifediol sufficiency remains a matter of debate. Vitamin D/calcifediol deficiency has been associated with musculoskeletal effects but also multiple adverse extra-skeletal consequences. If these consequences improve or if they can be treated with vitamin D supplementation is still unclear. Observational studies suggest a higher infection risk in people with low calcifediol levels. There is also a consistent association between serum calcifediol and cardiovascular events and deaths, but large-scale, long-term intervention studies did not show any benefit on cardiovascular outcomes from supplementation, at least not in subjects without clear vitamin D deficiency. Cancer risk also did not change with vitamin D treatment, although there are some data that higher serum calcifediol is associated with longer survival in cancer patients. In pregnant women, vitamin D supplementation decreases the risk of pre-eclampsia, gestational diabetes mellitus, and low birth weight. Although preclinical studies showed that the vitamin D endocrine system plays a role in certain neural cells as well as brain structure and function, there is no evidence to support a beneficial effect of vitamin D in neurodegenerative diseases. Vitamin D supplementation may marginally affect overall mortality risk especially in elderly subjects with low serum calcifediol concentrations.

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Section: Consequences Of Vitamin D or Calcifediol Deficiency Musculos...mentioning

confidence: 84%

Calcifediol (25OH Vitamin D3) Deficiency: A Risk Factor from Early to Old Age

Bouillon

LʼAbbate

Rosero³

2022

Nutrients

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“…A fnal total of 14 studies, assessing a total of 2734 patients, were included to assess fracture outcomes following vitamin D supplementation [10,14,[23][24][25][26][27][28][29][30][31][32][33][34]. Nine of these were controlled trials of which seven were randomised and two were nonrandomised.…”

Section: Resultsmentioning

confidence: 99%

“…Te remaining four studies found no signifcant diferences between the majority of functional outcome scores [10,26,27,29]. Te study by Ko et al was graded as "fair," while the control trials ranged from "low risk of bias" to "serious concerns" [27].…”

Section: Functionalmentioning

confidence: 96%

“…Tere was a wide variation in vitamin D supplementation techniques amongst the studies. Te research identifed bolus dosing regimens ranging from 100,000 to 300,000 IU [14,27,28], daily dosing regimens ranging from 800 to 2000 IU daily [23][24][25][29][30][31], or a combination of bolus and daily dosing [26,33,34]. Supplementation forms included oral tablet, liquid drops, or intramuscular injections.…”

Section: Supplementation Strategymentioning

confidence: 99%

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The Effect of Vitamin D Supplementation for Bone Healing in Fracture Patients: A Systematic Review

Gatt

Grech

Arshad

2023

Advances in Orthopedics

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While most literature on vitamin D supplementation in fracture patients focuses on fracture prevention, the effect of vitamin D on bone healing is a much less studied concept. The primary aim of this systematic review was to assess whether vitamin D supplementation in fracture patients improves clinical or radiological union complications. The secondary aims were to assess supplementation effect on patient functional outcome scores and bone mineral density (BMD). A systematic search of all relevant articles was performed using the following databases: MEDLINE, Embase, Google Scholar, and Web of Science. The population selection included human patients with a fresh fracture treated conservatively or operatively. The intervention included any form of vitamin D supplementation, compared to no supplementation or a placebo. The primary outcomes assessed were clinical or radiological union rates or complications arising from the nonunion. The secondary outcomes assessed were functional outcome scores, BMD scores after treatment, and pain scores. A total of fourteen studies, assessing a total of 2734 patients, were included. Eight studies assessed the effect of vitamin D on clinical or radiological union. Five studies reported no significant difference in complication rates when supplementing fracture patients. Alternatively, three studies reported a positive effect with supplementation between the groups. One of these studies found a difference only for early orthopaedic complications (<30 days), but no differences in late complications. The other two studies found significant differences in clinical union; however, no changes were observed in radiological union. Six studies investigated functional outcome scores after supplementation. Four of these studies found no significant differences between most functional outcome scores. Only three studies reported BMD outcomes, one of which found limited effect on total hip BMD. The overall findings are that vitamin D alone does little to influence fracture healing and subsequent union rates or functional outcome. The studies suggestive of a positive effect were generally of a lower quality. Further high quality RCTs are needed to justify routine supplementation at the time of fracture.

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“…Vitamin D is an important factor in bone metabolism. Animal studies have shown that vitamin D3 supplementation has a positive effect on fracture healing ( 38 ). A clinical study found that serum FGF19 levels were negatively correlated with body weight and hip BMD in older adults older than 60 years ( 39 ).…”

Section: Fgf19 Subfamily In Metabolic Syndrome (Mets)mentioning

confidence: 99%

The Role of Fibroblast Growth Factor 19 Subfamily in Different Populations Suffering From Osteoporosis

Xia

Jia

et al. 2022

Front. Endocrinol.

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Fibroblast growth factor (FGF) 19 subfamily, also known as endocrine fibroblast growth factors (FGFs), is a newly discovered metabolic regulator, including FGF19, FGF21 and FGF23. They play significant roles in maintaining systemic homeostasis, regulating the balance of bile acid and glucolipid metabolism in humans. Osteoporosis is a chronic disease, especially in the current status of aging population, osteoporosis is the most prominent chronic bone disease, leading to multiple complications and a significant economic burden that requires long-term or even lifelong management. Members of the FGF family have been shown to be associated with bone mineral density (BMD), fracture repair and cartilage regeneration. Studies of the FGF19 subfamily in different populations with osteoporosis have been increasing in recent years. This review summarizes the role of the FGF19 subfamily in bone metabolism, and provides new options for the treatment of bone diseases such as osteoporosis.

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The Effect of Bolus Vitamin D3 Supplementation on Distal Radius Fracture Healing: A Randomized Controlled Trial Using HR-pQCT

Cited by 14 publications

References 52 publications

Calcifediol (25OH Vitamin D3) Deficiency: A Risk Factor from Early to Old Age

Calcifediol (25OH Vitamin D3) Deficiency: A Risk Factor from Early to Old Age

The Effect of Vitamin D Supplementation for Bone Healing in Fracture Patients: A Systematic Review

The Role of Fibroblast Growth Factor 19 Subfamily in Different Populations Suffering From Osteoporosis

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