The effect of bone marrow-derived mesenchymal stem cells on chemotherapy induced ovarian failure in albino rats

Gabr, Hala; Rateb, Moshira; Sissy, Maha Hamdi El; Seddiek, Hanan; Gouda, Sarah Ali Abdelhameed

doi:10.1002/jemt.22725

Cited by 36 publications

(21 citation statements)

References 27 publications

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“…MSCs could secrete a number of other angiogenic growth factors, such as hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), placental growth factor (PGF), and TGF- β . These factors are involved in the repair of damaged ovarian function [21, 28]. Whether NGF acts synergistically with these factors should be examined in further research.…”

Section: Discussionmentioning

confidence: 99%

Umbilical Cord Mesenchymal Stem Cell Transplantation Prevents Chemotherapy-Induced Ovarian Failure via the NGF/TrkA Pathway in Rats

Zheng

Jiang

et al. 2019

BioMed Research International

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Chemotherapy leads to a loss of fertility and reproductive endocrine function, thereby increasing the risk of premature ovarian failure (POF). Studies have suggested that the transplantation of mesenchymal stem cells could inhibit apoptosis in ovarian granulosa cells and improve follicular development. In the present study, the effects of human umbilical cord mesenchymal stem cell (UCMSC) transplantation on ovarian function after ovarian damage caused by chemotherapy and the mechanism underlying these effects were investigated. POF model rats were obtained by the intraperitoneal injection of cyclophosphamide, and cultured UCMSCs were transplanted by tail vein injection. Serum estrogen, follicle-stimulating hormone, gonadotropin releasing hormone, and anti-Mullerian hormone levels were detected by ELISA. Folliculogenesis was evaluated by histopathological examination. The expression levels of nerve growth factor (NGF), high affinity nerve growth factor receptor (TrkA), follicle-stimulating hormone receptor (FSHR), and caspase-3 were evaluated by western blotting and RT-qPCR. The natural reproductive capacity was assessed by pregnant rate and numbers of embryos. The results indicated that UCMSC transplantation recovered disturbed hormone secretion and folliculogenesis in POF rats. NGF and TrkA levels increased, while FSHR and caspase-3 decreased. The pregnancy rate of POF rats was improved. Therefore, UCMSCs could reduce ovarian failure due to premature senescence caused by chemotherapy, and the NGF/TrkA signaling pathway was involved in the amelioration of POF.

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Section: Discussionmentioning

confidence: 99%

Umbilical Cord Mesenchymal Stem Cell Transplantation Prevents Chemotherapy-Induced Ovarian Failure via the NGF/TrkA Pathway in Rats

Zheng

Jiang

et al. 2019

BioMed Research International

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“…Moreover, BMMSCs can reactivate folliculogenesis [39]. BMMSCs homed in the stroma of injured ovaries and the levels of insulinlike growth factor-1 (IGF-1) and tumor necrosis factor-α (TNF-α) increased in ovaries [40]. Human angiogenin promotes primordial follicle survival and angiogenesis in transplanted human ovarian tissue [41].…”

Section: Human Bone Marrow Mscs Characteristics Of Human Bone Marrow mentioning

confidence: 99%

Human mesenchymal stem cell treatment of premature ovarian failure: new challenges and opportunities

Shan

et al. 2021

Stem Cell Res Ther

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Premature ovarian failure (POF) is one of the common disorders found in women leading to 1% female infertility. Clinical features of POF are hypoestrogenism or estrogen deficiency, increased gonadotropin level, and, most importantly, amenorrhea. With the development of regenerative medicine, human mesenchymal stem cell (hMSC) therapy brings new prospects for POF. This study aimed to describe the types of MSCs currently available for POF therapy, their biological characteristics, and their mechanism of action. It reviewed the latest findings on POF to provide the theoretical basis for further investigation and clinical therapy.

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“…The ovarian function improvement with BMDSCs has also been proved by prolongation of reproductive potential in mice beyond the common age of reproductive senescence with monthly infusions of BMDSCs from young mice ( 88 ). The increase in the number of follicles and the size of the reproductive organs, as well as the restoration of hormonal levels have been described in genetically generated POF mice, and QT induced POF mice, rats, and rabbits after heterologous distal BMDSCs transplantation ( 90 , 91 , 98 ). In 2014, Liu et al.…”

Section: Stem Cell–based Approachesmentioning

confidence: 97%

Stem Cell Paracrine Signaling for Treatment of Premature Ovarian Insufficiency

2021

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Premature ovarian insufficiency is a common disorder affecting young women and represents the worst-case ovarian scenario due to the substantial impact on the reproductive lifespan of these patients. Due to the complexity of this condition, which is not fully understood, non-effective treatments have yet been established for these patients. Different experimental approaches are being explored and strategies based on stem cells deserve special attention. The regenerative and immunomodulatory properties of stem cells have been successfully tested in different tissues, including ovary. Numerous works point out to the efficacy of stem cells in POI treatment, and a wide range of clinical trials have been developed in order to prove safety and effectiveness of stem cells therapy—in diminished ovarian reserve and POI women. The main purpose of this review is to describe the state of the art of the treatment of POI involving stem cells, especially those that use mobilization of stem cells or paracrine signaling.

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The effect of bone marrow-derived mesenchymal stem cells on chemotherapy induced ovarian failure in albino rats

Abstract: Injected BM- MSCs can home in the stroma of the injured ovaries. IGF-I and TNF- α may have a role in the attraction of stem cells in vivo.

Cited by 36 publications

References 27 publications

Umbilical Cord Mesenchymal Stem Cell Transplantation Prevents Chemotherapy-Induced Ovarian Failure via the NGF/TrkA Pathway in Rats

Umbilical Cord Mesenchymal Stem Cell Transplantation Prevents Chemotherapy-Induced Ovarian Failure via the NGF/TrkA Pathway in Rats

Human mesenchymal stem cell treatment of premature ovarian failure: new challenges and opportunities

Stem Cell Paracrine Signaling for Treatment of Premature Ovarian Insufficiency

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