The Effect of Bovine Bone Graft With or Without Platelet-Rich Plasma on Maxillary Sinus Floor Augmentation

Cabbar, Fatih; Güler, Nurhan.; Kürkçü, Mehmet; İşerı, Ufuk; Şençift, Kemal

doi:10.1016/j.joms.2011.03.040

Cited by 39 publications

(51 citation statements)

References 36 publications

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“…On the contrary, some investigators have demonstrated no benefit or even a negative effect on bone regeneration with PRP. 23,24 It remains questionable whether or not the PRP can enhance new bone formation. In our study, the suture width was consistently less in the PRP gel group than in the control group, as shown on histological slices and micro-CT images (Figs.…”

Section: Discussionmentioning

confidence: 99%

Effects of Platelet-Rich Plasma and Recombinant Human Bone Morphogenetic Protein-2 on Suture Distraction Osteogenesis

Xu¹,

Ke²,

Zhang³

et al. 2013

Journal of Craniofacial Surgery

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In this animal model, both PRP gel and PRP/rhBMP-2 gel are effective in improving new bone formation in suture distraction osteogenesis. PRP gel induces suture bone formation without suture fusion and accelerates the suture wound healing, while the PRP/rhBMP-2 gel group, in which the sutures fused prematurely, showed powerful bone formation ability aided by rhBMP-2. PRP can be alternatively use as a controlled release system for rhBMP-2, but caution should be used before proceeding with the application of high-dose growth factors around the growing craniofacial sutures.

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Section: Discussionmentioning

confidence: 99%

Effects of Platelet-Rich Plasma and Recombinant Human Bone Morphogenetic Protein-2 on Suture Distraction Osteogenesis

Xu¹,

Ke²,

Zhang³

et al. 2013

Journal of Craniofacial Surgery

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“…There is a controversy in the literature related to the use of PRP in MSFE procedures. Although some studies found an effect of PRP on bone formation in combination with bone substitutes 104 and bone grafts, 106 other studies did not find such an effect when PRP was combined with a xenograft, 29 an autologous bone graft, 12 or a synthetic bone substitute. 87 Ex vivo seeded ASCs onto a scaffold secrete a high variety of angiogenic growth factors, such as VEGF and FGF-2, which makes them interesting candidates for inducing bone tissue formation.…”

Section: Scaffolds For Oral and Maxillofacial Bone Tissue Engineeringmentioning

confidence: 99%

“…28 The lack of quantitative or histomorphometric data becomes an important drawback in studies comparing different bone grafts for MSFE. 29 Clinically, it is difficult and timeconsuming to analyze a large number of samples, 13 and therefore it is desirable to generate a variety of studies with similar approaches, and to combine and compare these results in a meta-analysis.…”

Section: Bone Graft Materials In Msfementioning

confidence: 99%

“…Inorganic materials or ceramics from natural origin, such as calcium carbonate, calcium phosphate, calcium sulfate, bovine-derived, or coralline HA, and from synthetic origin, such as synthetic HA or b-TCP, have been widely used in MSFE due to their good biocompatibility and osteoconductivity, 10,26,[74][75][76][77][78][79] besides bone grafts, 13,16,17,26,29,74,77,78 polymers, 28,78,[80][81][82][83][84][85][86] and bioactive glass. 78,87,88 Synthetic Calcium Phosphate Scaffolds for Oral and Maxillofacial Bone Tissue Engineering HA and b-TCP have been successfully used for MSFE procedures because of their good biocompatibility and chemical composition, which resembles the composition of natural bone matrix.…”

Section: Scaffolds For Oral and Maxillofacial Bone Tissue Engineeringmentioning

confidence: 99%

“…62,119,120 For clinical application, it would be advantageous to transplant the whole SVF, thereby avoiding expensive and time-consuming in vitro 29 Human MSFE PRP -ABB 24 16 -4 Stravopoulos et al 75 Human MSFE GDF-5 -b-TCP 12 31 -17 16 28 -16 Koch et al (79) Human MSFE GDF-5 -b-TCP 12 31 -17 16 28. -16 Triplett et al 83 Human MSFE BMP-2 -Collagen + BMP-2 24 n.a.…”

Section: Bone Morphogenetic Protein-7mentioning

confidence: 99%

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Human Maxillary Sinus Floor Elevation as a Model for Bone Regeneration Enabling the Application of One-Step Surgical Procedures

Farré-Guasch

Prins

Overman

et al. 2013

Tissue Engineering Part B: Reviews

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Bone loss in the oral and maxillofacial region caused by trauma, tumors, congenital disorders, or degenerative diseases is a health care problem worldwide. To restore (reconstruct) these bone defects, human or animal bone grafts or alloplastic (synthetic) materials have been used. However, several disadvantages are associated with bone graft transplantation, such as limited bone volume, donor-site morbidity, surgical and immune rejection risks, and lack of osseo-integration. Bone tissue engineering is emerging as a valid alternative to treat bone defects allowing the regeneration of lost bony tissue, thereby recovering its functionality. During the last decades, the increasing aged population worldwide has also raised the prevalence of maxillary atrophy. Maxillary sinus floor elevation (MSFE) has become a standard surgical procedure to overcome the reduced amount of bone, thus enabling the placement of dental implants. MSFE aims to increase the bone height in the posterior maxilla, by elevating the Schneiderian membrane and placing the graft material into the surgically created space in the maxillary sinus floor. Importantly, oral bone regeneration during MSFE offers a unique human clinical model in which new cell-based bone tissue engineering applications might be investigated, since biopsies can be taken after MSFE before a dental implant placement and analyzed at the cellular level. New approaches in oral bone regeneration are focusing on cells, growth factors, and biomaterials. Recently, adipose tissue has become interesting as an abundant source of mesenchymal stem cells, which might be applied immediately after isolation to the patient allowing a one-step surgical procedure, thereby avoiding expensive cell culture procedures and another surgical operation. In this new cell-based tissue engineering approach, stem cells are combined with an osteoconductive scaffold and growth factors, and applied immediately to the patient. In this review, MSFE is discussed as a valid model to test bone tissue engineering approaches, such as the one-step surgical procedure. This procedure might be applied in other regenerative medicine applications as well.

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Clinical Cases in Implant Dentistry

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The Effect of Bovine Bone Graft With or Without Platelet-Rich Plasma on Maxillary Sinus Floor Augmentation

Cited by 39 publications

References 36 publications

Effects of Platelet-Rich Plasma and Recombinant Human Bone Morphogenetic Protein-2 on Suture Distraction Osteogenesis

Effects of Platelet-Rich Plasma and Recombinant Human Bone Morphogenetic Protein-2 on Suture Distraction Osteogenesis

Human Maxillary Sinus Floor Elevation as a Model for Bone Regeneration Enabling the Application of One-Step Surgical Procedures

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