The effect of BPA exposure on insulin resistance and type 2 diabetes – The impact of muscle contraction

Wade, Madison; Delawder, Virginia; Reneau, Paul; Santos, Júlia Matzenbacher dos

doi:10.1016/j.mehy.2020.109675

Cited by 22 publications

(14 citation statements)

References 46 publications

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“…It is noteworthy that the concentrations of BPA used in our study were very low, i.e., 1 and 10 nM and comparable with environmental exposure (Akash et al 2020 ; Wade et al 2020 ). Results of in vitro studies indicate that BPA may elicit contrary effects depending on its concentrations (Héliès-Toussaint et al 2014 ; Ramskov Tetzlaff et al 2020 ; Wade et al 2020 ). Our results have shown that the effects of this compound on adipocytes were not concentration-dependent, since similar changes were observed in the presence of 1 and 10 nM BPA.…”

Section: Discussionsupporting

confidence: 76%

“…It is thought that human populations worldwide are continuously being exposed to BPA, which largely contributes to numerous health problems. Exposure to BPA is associated, among others, with the risk of Parkinson disease, cancer, cardiovascular diseases, and metabolic disorders (Wade et al 2020 ). Results of many studies also suggest that BPA markedly contributes to the development of type 2 diabetes (Wade et al 2020 ).…”

Section: Introductionmentioning

confidence: 99%

“…Exposure to BPA is associated, among others, with the risk of Parkinson disease, cancer, cardiovascular diseases, and metabolic disorders (Wade et al 2020 ). Results of many studies also suggest that BPA markedly contributes to the development of type 2 diabetes (Wade et al 2020 ). Type 2 diabetes is a serious metabolic disease affecting about 5% of people worldwide.…”

Section: Introductionmentioning

confidence: 99%

“…Such an effect is mainly due to reduced phosphorylation of some proteins of the insulin signaling pathway. This is strongly associated with the reduction of insulin-induced glucose transport into the skeletal muscle (Mullainadhan et al 2017 ; Wade et al 2020 ). Given a large mass of the skeletal muscle, reduced intramuscular glucose transport is associated with elevated blood glucose levels (Blaak 2005 ).…”

Section: Introductionmentioning

confidence: 99%

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Bisphenol A disturbs metabolism of primary rat adipocytes without affecting adipokine secretion

Szkudelska

Okulicz

Szkudelski

2021

Environ Sci Pollut Res

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Bisphenol A (BPA) is an ubiquitous synthetic chemical exerting numerous adverse effects. Results of rodent studies show that BPA negatively affects adipose tissue. However, the short-term influence of this compound addressing adipocyte metabolism and adipokine secretion is unknown. In the present study, isolated rat adipocytes were exposed for 2 h to 1 and 10 nM BPA. Insulin-induced glucose conversion to lipids along with glucose transport was significantly increased in the presence of BPA. However, basal glucose conversion to lipids, glucose oxidation, and formation of lipids from acetate were unchanged in adipocytes incubated with BPA. It was also shown that BPA significantly increases lipolytic response of adipocytes to epinephrine. However, lipolysis stimulated by dibutyryl-cAMP (a direct activator of protein kinase A) and the antilipolytic action of insulin were not affected by BPA. Moreover, BPA did not influence leptin and adiponectin secretion from adipocytes. Our new results show that BPA is capable of disturbing processes related to lipid accumulation in isolated rat adipocytes. This is associated with the potentiation of insulin and epinephrine action. The effects of BPA appear already after short-term exposure to low doses of this compound. However, BPA fails to change adipokine secretion.

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Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Bisphenol A disturbs metabolism of primary rat adipocytes without affecting adipokine secretion

Szkudelska

Okulicz

Szkudelski

2021

Environ Sci Pollut Res

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“…The type 2 diabetes (T2D) epidemic is a prevalent matter of public health that has affected almost 10% of the global population (Wade et al 2020, WHO 2016. Various contributing factors to T2D development have been de ned, ranging between genetic, socioeconomic, cultural, environmental, and lifestyle in uences (Wade et al 2020, WHO 2016. Researchers have also strongly indicated that obesity and dyslipidemia are major contributors to T2D (Benite-Ribeiro et al 2020).…”

Section: Introductionmentioning

confidence: 99%

The effect of environmental estrogens exposure on oxidative stress and dyslipidemia, and their impact on insulin sensitivity

Riiffee

Wade

Sine

et al. 2022

Preprint

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Bisphenol A and S (BPA and BPS), chemicals used in food packaging, have been closely associated with insulin resistance. However, the mechanism by which BPA and BPS induces type 2 diabetes is debatable. The aim of this study was to investigate if oxidative stress mediates BPA and BPS’s effect on lipid profiles and glucose uptake via insulin and aerobic exercise. Normal weight and overweight/obese subjects participated in 2 separate testing days. On both days, blood glucose was measured before 50 g of maltodextrin consumption and following 30-, 60-, and 75-minutes. On the “Exercising” testing day, subjects ran for 30-minutes at 70% of maximal heart rate; while on the “Resting” day, they remained seated. Urinary BPA, BPS, 8-isoprostane (an oxidative stress marker), creatinine, lipid profile, body fat percentage and physical fitness were measured. The exercise condition produced a decrease in blood glucose during the 30-60-minute protocol interval within normal and overweight/obese subjects when compared to the resting day. Blood glucose of both experimental days was negatively associated with body fat (r=-0.58) only. Urinary BPA and BPS were positively associated with oxidative stress (r = 0.62 and 0.82, respectively). BPA and oxidative stress were negatively associated with physical fitness (r=-45 and − 0,5, respectively), while BPS and oxidative stress were associated with increased triglycerides (r = 0.47 and 0.49, respectively). Oxidative stress mediates the effect of BPA and BPS on risk factors related to T2D development. Thus, modulating oxidative stress could be a valuable strategy to attenuate the effect of bisphenols in the human body.

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An overview of the occurrence, fate, and human risks of the bisphenol‐A present in plastic materials, components, and products

Hahladakis

Iacovidou

Gerassimidou

2022

Integr Envir Assess & Manag

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With over 95% of bisphenol-A (BPA) used in the production of polycarbonate (PC) and epoxy resins, termed here as BPAbased plastic materials, components, and products (MCPs), an investigation of human exposure to BPA over the whole lifecycle of BPA-based plastic MCPs is necessary. This mini-review unpacks the implications arising from the long-term human exposure to BPA and its potential accumulation across the lifecycle of BPA-based plastics (production, use, and management). This investigation is timely and necessary in promoting a sustainable circular economy model. Restrictions of BPA in the form of bans and safety standards are often specific to products, while safety limits rely on traditional toxicological and biomonitoring methods that may underestimate human health implications and therefore the "safety" of BPA exposure. Controversies in regards to the: (a) dose-response curves; (b) the complexity of sources, release mechanisms, and pathways of exposure; and/or (c) the quality and reliability of toxicological studies, appear to currently stifle progress toward the regulation of BPA-based plastic MCPs. Due to the abundance of BPA in our MCPs production, consumption, and management systems, there is partial and inadequate evidence on the contribution of BPA-based plastic MCPs to human exposure to BPA. Yet, the production, use, and end-of-life management of plastic MCPs constitute the most critical BPA source and potential exposure pathways that require further investigation. Active collaboration among risk assessors, government, policy-makers, and researchers is needed to explore the impacts of BPA in the long term and introduce restrictions to BPA-based MCPs.

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The effect of BPA exposure on insulin resistance and type 2 diabetes – The impact of muscle contraction

Cited by 22 publications

References 46 publications

Bisphenol A disturbs metabolism of primary rat adipocytes without affecting adipokine secretion

Bisphenol A disturbs metabolism of primary rat adipocytes without affecting adipokine secretion

The effect of environmental estrogens exposure on oxidative stress and dyslipidemia, and their impact on insulin sensitivity

An overview of the occurrence, fate, and human risks of the bisphenol‐A present in plastic materials, components, and products

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