To reduce the risk of breast disease in women, we proposed a new smart bra design scheme. We implanted high-precision temperature sensors into the bra for real-time data monitoring, and used multipoint comparison technology to obtain early warnings of breast lesions based on abnormal temperature data. The proposed monitoring system can perform functions such as real-time data feedback, periodic report recording, remote consultation, health management, and electronic medical record generation. Compared with previous approaches, the functionality of this smart bra is not affected by dynamic body movements or environmental temperature, and its monitoring range for breast diseases is wider. This study promotes the monitoring and prevention of breast diseases in women, leading to a shift from disease treatment to disease prevention.