2014
DOI: 10.1371/journal.pone.0084845
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The Effect of Brain-Derived Neurotrophic Factor on Periodontal Furcation Defects

Abstract: This study aimed to observe the regenerative effect of brain-derived neurotrophic factor (BDNF) in a non-human primate furcation defect model. Class II furcation defects were created in the first and second molars of 8 non-human primates to simulate a clinical situation. The defect was filled with either, Group A: BDNF (500 µg/ml) in high-molecular weight-hyaluronic acid (HMW-HA), Group B: BDNF (50 µg/ml) in HMW-HA, Group C: HMW-HA acid only, Group D: empty defect, or Group E: BDNF (500 µg/ml) in saline. The h… Show more

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Cited by 18 publications
(31 citation statements)
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“…Regarding the effect of BDNF on bone, several studies have indicated that BDNF has positive effects on bone formation and regeneration in in vivo bone fracture models [10,11,23,24]. In our in vitro study, mRNA expression of osteoblast differentiation marker, osteocalcin, was significantly increased by BDNF, although cell proliferation and migration were not affected in MC3T3-E1 cells.…”
Section: Discussionmentioning
confidence: 48%
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“…Regarding the effect of BDNF on bone, several studies have indicated that BDNF has positive effects on bone formation and regeneration in in vivo bone fracture models [10,11,23,24]. In our in vitro study, mRNA expression of osteoblast differentiation marker, osteocalcin, was significantly increased by BDNF, although cell proliferation and migration were not affected in MC3T3-E1 cells.…”
Section: Discussionmentioning
confidence: 48%
“…Jimbo et al . applied recombinant BDNF to periodontal furcation bone defects in non-human primates and showed that BDNF promoted alveolar bone regeneration [23]. These reports supported the possibility of local BDNF control for bone regeneration and/or normal healing of bone defects caused by tooth extraction.…”
Section: Discussionmentioning
confidence: 92%
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“…After that, Bertl et al (2015) showed that the HA application as adjunct to non‐surgical and surgical periodontal therapy seems to have a beneficial, generally moderate effect on periodontal inflammation . Furthermore, Jimbo et al (2014) found that HA scaffolds allowed for alveolar bone regeneration …”
Section: Discussionmentioning
confidence: 99%
“…Indeed, in these specific periodontal defects, the ability of the scaffolds to swell when they are placed in biological media may be of great interest to enhance tissue regeneration. If needed for enhancing tissue regeneration, using growth factors combined with this scaffold may be promising for investigation as recent studies have demonstrated the positive influence of brain‐derived neurotrophic factor – HA scaffolds in periodontal regeneration …”
Section: Discussionmentioning
confidence: 99%