The effect of breakfast with different macronutrient composition on PYY, ghrelin, and ad libitum intake 4 h after breakfast in Indonesian obese women

Witjaksono, Fiastuti; Wijaya, Andi; Annisa, Nagita Gianty; Jutamulia, Joan; Nurwidya, Fariz; Simadibrata, Marcellus

doi:10.1186/s13104-018-3895-3

Cited by 4 publications

(2 citation statements)

References 21 publications

(24 reference statements)

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“…A study published in 2018 showed that calorie restriction significantly reduced waist circumference compared to high-protein diet. The study also states that a slightly lower reduction of waist circumference in the high-protein group compared to the standard protein group might be caused by the slightly higher mean daily calorie intake in the high protein group (7).…”

Section: Discussionmentioning

confidence: 88%

A pilot study of high-protein diet consumption and its effects on waist circumference and body fat percentage among gym goers in Cyberjaya

Arrasyid

Zaizilan

Yee

et al. 2022

ijhs

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Introduction: High-protein diet, whereby 1.2 – 1.6g protein/kg of body weight is consumed per day, has been popularised as a weight-loss technique. While some people truly believe in its health benefits, some consume high-protein diets for other reasons. However, it is not yet proven whether consuming a high-protein diet improves your overall health. Thus this study is to discover if consuming a high-protein diet has any health benefits. We focus our study on the evidence of the impact of a high-protein diet on those who routinely exercise, either by weightlifting or cardio. Methods: This cross-sectional study was carried out among gym goers in Cyberjaya aged 18 years and above and have not been diagnosed with any underlying disease (N=46). Data collection was done via online interview and individual questionnaire and analysed using Pearson chi-square and Fisher’s exact test with SPSS version 26. The statistical significance level was set at 0.05. Results: Majority of the gym goers in Cyberjaya we sampled consumed a high-protein diet (57.8%).

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Section: Discussionmentioning

confidence: 88%

A pilot study of high-protein diet consumption and its effects on waist circumference and body fat percentage among gym goers in Cyberjaya

Arrasyid

Zaizilan

Yee

et al. 2022

ijhs

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“…These PYY peptides circulate in plasma and act through Y receptors, Y1, 2 and 5, to regulate food intake and beta-cell mass [[8], [9], [10], [11], [12], [13]]. Systemic PYY levels are low in the fasted state and increase in response to nutrient ingestion [10,14,15]. Paradoxically, the level of circulating post-prandial PYY is increased following bariatric surgery, particularly procedures that result in the rapid delivery of nutrients to L-cells in the ileum and colon such as Roux-en-Y gastric bypass [16].…”

Section: Introductionmentioning

confidence: 99%

PYY is a negative regulator of bone mass and strength

Leitch

Brassill

Rahman

et al. 2019

Bone

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Objective Bone loss in anorexia nervosa and following bariatric surgery is associated with an elevated circulating concentration of the gastrointestinal, anorexigenic hormone, peptide YY (PYY). Selective deletion of the PYY receptor Y1R in osteoblasts or Y2R in the hypothalamus results in high bone mass, but deletion of PYY in mice has resulted in conflicting skeletal phenotypes leading to uncertainty regarding its role in the regulation of bone mass. As PYY analogs are under development for treatment of obesity, we aimed to clarify the relationship between PYY and bone mass. Methods The skeletal phenotype of Pyy knockout (KO) mice was investigated during growth (postnatal day P14) and adulthood (P70 and P186) using X-ray microradiography, micro-CT, back-scattered electron scanning electron microscopy (BSE-SEM), histomorphometry and biomechanical testing. Results Bones from juvenile and Pyy KO mice were longer ( P < 0.001), with decreased bone mineral content ( P < 0.001). Whereas, bones from adult Pyy KO mice had increased bone mineral content ( P < 0.05) with increased mineralisation of both cortical ( P < 0.001) and trabecular ( P < 0.001) compartments. Long bones from adult Pyy KO mice were stronger (maximum load P < 0.001), with increased stiffness ( P < 0.01) and toughness ( P < 0.05) compared to wild-type (WT) control mice despite increased cortical vascularity and porosity ( P < 0.001). The increased bone mass and strength in Pyy KO mice resulted from increases in trabecular ( P < 0.01) and cortical bone formation ( P < 0.05). Conclusions These findings demonstrate that PYY acts as a negative regulator of osteoblastic bone formation, implicating increased PYY levels in the pathogenesis of bone loss during anorexia or following bariatric surgery.

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Effects of gastric bypass bariatric surgery on gut microbiota in patients with morbid obesity

Amin,

Huang,

Dhir

et al. 2024

Gut Microbes

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The Western diet is associated with gastrointestinal dysbiosis, an active contributor to the pathophysiology of obesity and its comorbidities. Gastrointestinal dysbiosis is strongly linked to increased adiposity, low-grade inflammation, dyslipidaemia, and insulin resistance in individuals with morbid obesity. Bariatric bypass surgery remains the most effective treatment for achieving significant weight loss and alleviating obesity-related comorbidities. A growing body of evidence indicates that traditional Roux-en-Y Gastric Bypass (RYGB) improves the disrupted gut microbiota linked with obesity, potentially contributing to sustained weight loss and reduction of comorbidities. One Anastomosis Gastric Bypass (OAGB), a relatively new and technically simpler bariatric procedure, has shown both safety and efficacy in promoting weight loss and improving comorbidities. Few studies have investigated the impact of OAGB on gut microbiota. This review provides insights into the pathogenesis of obesity, current treatment strategies and our current understanding of the gut microbiota in health and disease, including modulating the gut microbiota as a promising and novel way to alleviate the burden of obesity and cardiometabolic conditions. By exploring the impact of gastric bypass surgery on gut microbiota-host interactions, we aim to shed light on this evolving field of research and uncover potential therapeutic targets for elevating outcomes in bariatric surgery.

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The effect of breakfast with different macronutrient composition on PYY, ghrelin, and ad libitum intake 4 h after breakfast in Indonesian obese women

Cited by 4 publications

References 21 publications

A pilot study of high-protein diet consumption and its effects on waist circumference and body fat percentage among gym goers in Cyberjaya

A pilot study of high-protein diet consumption and its effects on waist circumference and body fat percentage among gym goers in Cyberjaya

PYY is a negative regulator of bone mass and strength

Effects of gastric bypass bariatric surgery on gut microbiota in patients with morbid obesity

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