The Effect of Bromazepam on Psychomotor Activity and Subjective Mood

Abstract

The effects of short-term (acute) doses of bromazepam were studied in a double-blind trial with the aid of three dosage groups comprising a total of fifty-five healthy male medical students (who received placebo, and 1.5 mg or 3.0 mg bromazepam, respectively). Subjective well-being was recorded through self-ratings by the volunteers, and the variables of psychomotor function by standard testing instruments. In terms of subjective well-being, fatigue and decreased performance (statistically confirmed throughout) were reported by the probands in all three dosage groups after they were administered either the drug or placebo. None of the dose-effect relationships were statistically significant, although this trend was more pronounced, purely in quantitative terms, in the group that received 3 mg bromazepam than in either the placebo or the 1.5 mg bromazepam group. In the reaction time and in critical flicker-frequency (CFF) testing, the trend mentioned above was confirmed. In the attentiveness and memory span test, learning effects were statistically confirmed in equally uniform fashion. The action of the substance was again not statistically significant. It may be concluded from this that subjective, and also in part objective, fatigue and decreased performance were related to the type of trial design employed, and not, generally speaking, to the action of the substance. However, again independently of the drug's activity, statistical confirmation was obtained of improved performance and/or learning activity in three variables of the alertness testing apparatus. Variables of driving ability were not adversely affected, but--if anything--stabilized. Our investigation studied the single-dose schedules of bromazepam--viz. 1.5 mg and 3 mg--that are most commonly prescribed for patients. The subacute and personality-related effects of the drug will be the subject of a later report.

Effects of a cognitive modulator in the theta and alpha asymmetry during a typewriting task: a sensorimotor integration perspective

“…Our interpretation is that in this region proprioceptive information (e.g., hand and finger's position on keyboard) and other essential sensory information are joined to assist motor planning 24,25 . The lower positive asymmetry observed, more specially, in the Br 6 mg, supports the report of hobi et al 2 , when it was observed a higher stabilization of the psychomotor performance due to bromazepam effects. Our results suggest that such experimental condition provide a higher functional integration between the left and right cerebral hemispheres, particularly, among sensorimotor areas that compose a parietofronto-central loop.…”

“…Considerable positive effects have been shown when bromazepam is used in the treatment of anxiety disorders. however, several experiments have reported conflicting results through tests such as, memory span, critical flicker-frequency, digit symbol substitution, choice reaction time and critical fusion frequency [2][3][4][5][6] . such conflicts seem to be related to different methodologies performed in a few experiments associated with the effects of bromazepam during specific tasks.…”

Biomarkers for the effects of benzodiazepines in healthy volunteers

“…The literature search yielded 56 different studies using 16 different benzodiazepines, published since 1966 [14–67]. There were 173 different tests used, on average 3.1 tests per study.…”

Efectos del bromacepam sobre la variación negativa contingente y el tiempo de reacción en una tarea visuomotora

“…Tal y como sucedió con 5 y 10 mg de diacepam [28], con 0,25 mg de triazolam [29], con 0,5 y 2 mg de loracepam [30,31] y también con 0,04 mg/kg de midazolan [32], en nuestro experimento el TR no se vio afectado significativamente por 3 y 6 mg de bromacepam en relación con placebo. En esto coincidieron Jansen et al [20], con 6 mg de bromacepam, y Hobi et al [21] con 3 mg. Am-…”

“…Jansen et al [20] hallaron que la sensibilidad a los estímulos había disminui- do de manera estadísticamente significativa sólo tras la toma de 12 mg de bromacepam, pero no en el caso de 6 mg, al estudiar 20 sujetos sanos. Hobi et al [21], al estudiar 55 casos, encontraron una tendencia a la diferencia significativa en el TR de 3 mg de bromacepam, comparado con el de 1,5 mg y el placebo [21].…”