Envelope Building materials play an important role in architecture by providing protectionnecessities, comfort, and technical performance while promoting an architectural language and an image.The building envelope represents all the surfaces of a space, which consist of opaque parts such as walls,floors and roofs and transparent parts such as windows and openings. The building envelope is thepartition between the external and internal environment of the building which influences the heat transferbetween the two environments so it has a direct impact on the thermal comfort sensation which alsoinfluences the energy consumptions. This research focuses on the opaque building materials of theenvelope and their contribution in the thermal comfort and the energy consumption; an investigation ofthe impact and the thermal behavior of different envelope configuration materials under the climaticconditions of Biskra was carried, Algeria a hot and arid climate. The thermal performance of differentmaterials was compared using in situ measurement using “Testo 480” a hygrothermal scale and byanalyzing the results of a different simulation using “DesignBuilder v5.5” to perform a thermal andenergy analysis. The results show that choosing a multilayered isolated envelope such as double red brickisolated wall will likely affect positively the level of the indoor thermal comfort.