The effect of CA1 α2 adrenergic receptors on memory retention deficit induced by total sleep deprivation and the reversal of circadian rhythm in a rat model

Norozpour, Yaser; Nasehi, Mohammad; Sabouri-Khanghah, Vahid; Nami, Mohammad; Zarrindast, Mohammad‐Reza

doi:10.1016/j.nlm.2016.06.004

Cited by 21 publications

(9 citation statements)

References 55 publications

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“…α2 receptors in the CA1 region of the hippocampus play an important role in regulating sleep and memory retention processes. The activation and deactivation of CA1 α2 adrenergic receptors by clonidine and yohimbine, respectively, followed by total SD, shows that total SD and reversal of circadian rhythm impair memory functions (Norozpour et al 2016). This suggests the important role of the adrenergic system in sleep and memory.…”

Section: Adrenergic Systemmentioning

confidence: 96%

Sleep, brain vascular health and ageing

et al. 2020

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Sleep maintains the function of the entire body through homeostasis. Chronic sleep deprivation (CSD) is a prime health concern in the modern world. Previous reports have shown that CSD has profound negative effects on brain vasculature at both the cellular and molecular levels, and that this is a major cause of cognitive dysfunction and early vascular ageing. However, correlations among sleep deprivation (SD), brain vascular changes and ageing have barely been looked into. This review attempts to correlate the alterations in the levels of major neurotransmitters (acetylcholine, adrenaline, GABA and glutamate) and signalling molecules (Sirt1, PGC1α, FOXO, P66 shc , PARP1) in SD and changes in brain vasculature, cognitive dysfunction and early ageing. It also aims to connect SD-induced loss in the number of dendritic spines and their effects on alterations in synaptic plasticity, cognitive disabilities and early vascular ageing based on data available in scientific literature. To the best of our knowledge, this is the first article providing a pathophysiological basis to link SD to brain vascular ageing.

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Section: Adrenergic Systemmentioning

confidence: 96%

Sleep, brain vascular health and ageing

et al. 2020

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“…Approximately 5-7 days were required for animals' recovery after the operation. 27 29 This apparatus consists of a water tank made of clear Plexiglas (120×30×50 cm) divided into 4 equal boxes (30×30×50 cm), with water temperature being set at 30 centigrade degrees. Four rats were put together in the tank (one rat in each box) with the aim to keep social stability.…”

Section: Stereotactic Surgerymentioning

confidence: 99%

“…Behavioral observations obtained during daily SD indicated that rats were awaked 100% of the time when platform technique was applied. 29 The rats were deprived from sleep for 24 hours (TSD) for the purposes of the present study. Standard conditions were provided to keep animals (12:12 hours light-dark cycle in a temperature under control [22 ± 2ºC]) during SD phase.…”

Section: Stereotactic Surgerymentioning

confidence: 99%

“…After returning the stylets the animals were transferred into their cages. 29 Step-Through Apparatus for Memory Assessment Passive avoidance learning apparatus included a box divided into 2 partitions with equivalent sizes (20×20×30) by a wall. A guillotine door was located in the middle of the wall with dimensions of 7×9 (cm) and could be removed when it was required.…”

Section: Intra-ca1 Injectionmentioning

confidence: 99%

“…Each animal was located in the light compartment for twenty seconds after which the door was opened and delay in entrance into the dark compartment was recorded during the period which lasted for 300 seconds. 29 …”

Section: Retrieval Testmentioning

confidence: 99%

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