The Effect of Cabbage (Brassica oleracea var. capitata L.) Extract on Macrophage and Blood Vessel Counts in Clean Wound Tissue of Male Rats (Rattus norvegicus)

Abstract

Highlights : Cabbage extract application accelerates wound healing and has anti-inflammatory effect. Cabbage extract serves as an affordable source material for wound healing and anti-inflammation. Abstract Cabbage is a widely consumed vegetable known for its health benefits due to its rich nutrients and phytochemicals, especially phenolic compounds, which are known to have potent anti-inflammatory and antioxidant effects. This study aimed to investigate the effects of cabbage extract on wound healing by observing inflammatory responses in wound tissue. A total of 24 male rats were divided into four groups, with six rats in each group. The experiment was conducted for five days by administering cabbage extract to the treatment group and distilled water to the control group. Skin wound tissues were collected from all rats for histological observation by counting the number of macrophages and blood vessels. The results of the observation were analyzed statistically using an independent sample t-test with p<0.05. The results showed that the number of macrophages and blood vessels in the treatment group was significantly higher than the control group on the third day and significantly lower on the fifth day. In conclusion, the administration of cabbage extract can accelerate the inflammatory and proliferative phases of wound healing by promoting the migration of cells, including macrophages, resulting in accelerated angiogenesis. In addition, the decreased number of macrophages and blood vessels during the proliferative phase showed that the healing phase had reached a more advanced stage.

Comparative Analysis of Antioxidant Activity, ROS, and Relative Water Content Between Red and Green Cabbage

“…Phytochemicals such as vitamin C, flavonoids, carotenoids, and other phenolics are the constituents that contribute to this property. Due to its antioxidant (Vega-Galvez et al 2023;Liang et al 2019) anti-inflammatory (Kasarello et al 2022), and antibacterial (Arrais et al 2022) properties, cabbage has widespread use in traditional medicine (Gruszecki et al 2022), in the alleviation of symptoms associated with gastrointestinal disorders (gastritis, peptic and duodenal ulcers, irritable bowel syndrome) as well as in the treatment of minor cuts and wounds and mastitis (Melim et al 2022;Abramowitz et al 2022;Tsania, Willy, and Sawitri 2023). Fresh cabbage juice, prepared either separately or mixed with other vegetables such as carrots and celery, is often included in many commercial weight-loss diets (Šamec et al 2011).…”