The effect of cadmium on the hematology and on the activity of δ-aminolevulinic acid dehydratase (ALA-D) in blood and hematopoietic tissues of the flounder, Pleuronectes flesus L.

Johansson‐Sjöbeck, Maj‐Lis; Larsson, Åke

doi:10.1016/0013-9351(78)90021-x

Cited by 88 publications

(15 citation statements)

References 22 publications

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“…Although the mitogenic response to LPS of the splenocytes from cadmiumexposed fish was not affected, the enhanced antibody production to V. anguillarum 0-antigen in the 3.6 pg Cd l-' group may be related to a cadmium-induced stimulation of B lymphocyte activity, as has been documented in mammals (Schenker et NI., 1977;Koller ef al., 1979). The increased amount of humoral antibodies could also be due to a lymphocytosis which has been reported previously from studies on cadmium-exposed fish (Johansson-Sjobeck & Larsson, 1978;Sjobeck et al, 1984). N o attempts to calculate the total number of lymphocytes were, however, made in the present study.…”

Section: Discussioncontrasting

confidence: 50%

“…Haematological studies of fish exposed to cadmium include a laboratory study of flounder, Pleuronectes Jesus L., (Johansson-Sjobeck & Larsson, 1978) and a field study of perch, Perca juviatilis, from a cadmium-contaminated river in the south of Sweden (Sjobeck et al, 1984): in both studies an increased number of blood lymphocytes was reported in the cadmium-exposed fish.…”

Section: Introductionmentioning

confidence: 99%

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Cadmium exposure of rainbow trout, Salmo gairdneri Richardson: effects on immune functions

Thuvander

1989

Journal of Fish Biology

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Differential leucocyte counts, phagocytosis, humoral antibody response and the in vitro blastogenetic response to mitogens (lipopolysaccharide and Concanavalin A) and to an antigen ( Vibrio anguiNarum) were studied in rainbow trout exposed to 0,0.7 or 3.6 pg Cd I-' for 12 weeks.Although the fish did not exhibit any clinical or histological changes, cadmium exposure was found to affect two of the immune parameters measured. The cellular response of fish immunized with V. anguillarum to the homologous antigen was significantly lower for splenocytes obtained from fish exposed to cadmium for 9 weeks (3.6 pg Cd I-' group) than for splenocytes obtained from non-exposed fish. Conversely, the humoral antibody response to V. anguillarum 0-antigen was higher in the 3.6 pg Cd I-' group than in the non-exposed group. Protective immunity of fish vaccinated against V. anguillarum was equally as good in the cadmium-exposed group as in the non-exposed group. No cadmium-induced changes in differential leucocyte counts or in the proportions of phagocytic cells were observed.

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Section: Discussioncontrasting

confidence: 50%

Section: Introductionmentioning

confidence: 99%

Cadmium exposure of rainbow trout, Salmo gairdneri Richardson: effects on immune functions

Thuvander

1989

Journal of Fish Biology

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“…Gill & Epple (1993) did not find differences in the MCHC and MCV between control and Cd‐exposed eel, although Cd‐exposed eels did become anaemic. Likewise, Johansson‐Sjobeck & Larsson (1978) observed that MCV, MCH, and MCHC did not change in flounder following 9 weeks of exposure to 5, 50, and 500 μg‐Cd L −1 . However, the dietary Cd‐exposed rockfish were anaemic and MCV and MCH were significantly lower than that in the control fish.…”

Section: Discussionmentioning

confidence: 84%

Effect of dietary cadmium on growth and haematological parameters of juvenile rockfish, Sebastes schlegeli (Hilgendorf)

Kim

Kang

2004

Aquac Research

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Experiments were carried out to investigate the growth and haematological parameters in juvenile rockfish, Sebastes schlegeli, exposed to sub‐chronic dietary cadmium (Cd) (0, 0.5, 5, 25, and 125 mg kg−1) for 60 days. The daily growth rates of weight and length of the rockfish were significantly different from control, and a significant inverse relationship was observed between weight gain and the exposure concentration of dietary Cd at 25 and 125 mg kg−1 (P<0.05). Glucose in serum was also increased significantly (P<0.05). The concentration of total protein in serum was significantly lower than control at 5, 25, and 125 mg kg−1. No differences were observed in serum calcium concentration. The magnesium concentration in serum was increased significantly with dietary Cd concentration.

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“…The reported effects of cadmium on fish include gill and kidney damage (Gardner & Yevich, 1970;Stromberg et al, 1983), poor bone mineralization (Muramoto,198 l), anaemia (Johansson-Sjobeck & Larsson, 1978) and retarded growth (Westernhagen et al, 1980). The exact mechanism of cadmium poisoning in fish is difficult to establish, but effects on the gills, which serve as a major organ for osmotic regulation as well as for respiration, have frequently been reported.…”

Section: Introductionmentioning

confidence: 99%

Cadmium‐induced changes in gill morphology of zebrafish, Brachydanio rerio (Hamilton–Buchanan), and rainbow trout, Salmo gairdneri Richardson

Karlsson-Norrgren

Runn

Haux

et al. 1985

Journal of Fish Biology

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Freshwater zebrafish and brackish water rainbow trout were exposed to different concentrations of cadmium for up to 6 weeks. The gill morphology was examined by light and electron microscopy, and a morphometric analysis was performed. The morphometric study of the secondary lamellae revealed an increase in the portion exterior to the basal lamina, resulting in an increased diffusion distance, after exposure to cadmium concentrations of IOpgl-' and above. In both species this was due to an increase in volume of the non-tissue spaces of the secondary lamellar epithelium. Furthermore, the water space between neighbouring secondary lamellae was clearly reduced. Morphological examination revealed some gross alterations compared with control fish. These initially consisted in curling of the secondary lamellae and finally resulted in local teleangiectasia. Partial lifting of the secondary lamellar epithelium from the pillar cells resulted in large non-tissue spaces which were invaded by leucocytes. The first sign of degeneration was observed in the chloride cells, which were characterized by a dispersed cytoplasm and a smooth apical plasma membrane.

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The effect of cadmium on the hematology and on the activity of δ-aminolevulinic acid dehydratase (ALA-D) in blood and hematopoietic tissues of the flounder, Pleuronectes flesus L.

Cited by 88 publications

References 22 publications

Cadmium exposure of rainbow trout, Salmo gairdneri Richardson: effects on immune functions

Cadmium exposure of rainbow trout, Salmo gairdneri Richardson: effects on immune functions

Effect of dietary cadmium on growth and haematological parameters of juvenile rockfish, Sebastes schlegeli (Hilgendorf)

Cadmium‐induced changes in gill morphology of zebrafish, Brachydanio rerio (Hamilton–Buchanan), and rainbow trout, Salmo gairdneri Richardson

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