The Effect of Caffeic Acid on Wound Healing in Skin-incised Mice

Song, Ho Sun; Park, Tae Wook; Sohn, Uy Dong; Shin, Yong Kyoo; Choi, Byung Chul; Kim, Chang Jong; Sim, Sang Soo

doi:10.4196/kjpp.2008.12.6.343

Cited by 76 publications

(56 citation statements)

References 22 publications

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“…9,13,21) Recent study indicated that CA had anti-inflammatory effects by reducing MPO activity and phospholipase A 2 activity in skin-incised mice. 14) However, the mechanisms underlying the anti-inflammatory effects of CA in skin inflammation are only partially understood. TPA-induced mouse ear inflammation model mimics several aspects of skin diseases, 15) and this model is reliable in vivo model system to evaluate compounds for both acute and chronic effects in skin inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…13) Furthermore, the study of Song et al indicated that CA had anti-inflammatory effects by reducing myeloperoxidase (MPO) activity and phospholipase A 2 activity in skin-incised mice. 14) However, the mechanisms underlying the anti-inflammatory effects of CA in skin inflammation are so far, only partially understood. Hence, the aim of this study was to investigate the effects and mechanisms of CA in acute and chronic skin inflammation in mice and also to study the effect of CA on the TNF-α production, the TNF-α-induced IL-6 and IL-1β production, and TNF-α-induced NF-κB activation in human keratinocytes.…”

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confidence: 99%

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Caffeic Acid Reduces Cutaneous Tumor Necrosis Factor Alpha (TNF-α), IL-6 and IL-1β Levels and Ameliorates Skin Edema in Acute and Chronic Model of Cutaneous Inflammation in Mice

Zhang

Zhou

Wang

et al. 2014

Biological & Pharmaceutical Bulletin

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Caffeic acid (3,4-dihydroxycinnamic acid, CA) has been reported to have anti-inflammatory activity in animal models. However, the mechanisms underlying the anti-inflammatory effects of CA in skin inflammation are only partially understood. The present study was designed to investigate the effects and mechanisms of CA on acute and chronic skin inflammation in mice and the effect of CA in keratinocytes in vitro. The results showed that topical treatment with CA inhibited 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced skin edema in a dose-dependent manner, leading to substantial reductions in skin thickness and tissue weight, neutrophil-mediated myeloperoxidase activity, and various histopathological indicators. The CA treatment also significantly reduced the mRNA and protein levels of tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6) and IL-1β at the application site, and the TNF-α production, the TNF-α-induced IL-6 and IL-1β production, and TNF-α-induced nuclear factor-kappa B (NF-κB) activation in human keratinocytes in vitro. Furthermore, CA was effective at reducing inflammatory damage induced by chronic TPA exposure. These results demonstrate that CA has anti-inflammatory activities in both acute and chronic contact dermatitis models via blockade of the mRNA and protein synthesis of these cytokines and neutrophil-mediated myeloperoxidase activity, and can target inflammatory mediators specifically in the keratinocytes. Taken together, the present results suggest that CA might be a therapeutic agent against inflammatory skin diseases.Key words 3,4-dihydroxycinnamic acid; pro-inflammatory cytokine; keratinocyte; 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced ear edema modelThe skin is an immune organ consisting of epidermal cells, i.e., keratinocytes and Langerhans cells.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Caffeic Acid Reduces Cutaneous Tumor Necrosis Factor Alpha (TNF-α), IL-6 and IL-1β Levels and Ameliorates Skin Edema in Acute and Chronic Model of Cutaneous Inflammation in Mice

Zhang

Zhou

Wang

et al. 2014

Biological & Pharmaceutical Bulletin

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“…As phenolic compounds express anti-allergic and anti-inflammatory effects (Kimura and Okuda, 1987;Shimoda et al, 2006;Song et al, 2008), they may be the active compounds in the burdock methanol extracts.…”

Section: Resultsmentioning

confidence: 99%

Anti-allergic Effects of Extracts from Commercial Products of Cooked Burdock

Sugiura

Torii

Matsuda

et al. 2009

FSTR

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The anti-allergic effects of commercial products from cooked burdock (burdock salad, fried up burdock and burdock boiled with vinegar) were investigated by analyzing their inhibitory effects on the enzymatic activity (cyclooxygenase-2, lipoxygenase, phospholipase A 2 and hyaluronidase) and the suppression of degranulation from rat basophilic leukemia (RBL)-2H3 cells. The methanol extract of burdock boiled with vinegar did not inhibit the cyclooxygenase-2 activity in the experiments. Those of the burdock salad and fried up burdock exhibited inhibitory activities in all the experiments. The burdock salad extract strongly inhibited lipoxygenase, phospholipase A 2 and hyaluronidase. Thus, commercial cooked burdock, in addition to raw burdock, has bioactivities corresponding to an anti-allergic effect.

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“…31 Song et al reported that CAPE increase collagen-like polymer levels secreted by fibroblasts. 32 Tanimoto et al (2012) and Bushra Habeeb Al-Molla (2014) found that propolis enhanced the bone formation in one week and stated that amelogenins increases the mineralisation accompanied by the up-regulation of bone markers in human bone marrow MSCs during osteogenic differentiation. This suggests a certain role of amelogenin and propolis in the modulation of osteogenic differentiation of MSCs.…”

Section: Summary Of the Studies Includedmentioning

confidence: 99%

Effect of Propolis on Bone Loss Prevention- A Review

Sowmya¹,

Gujjari²,

Mruthunjaya³

et al. 2017

jemds

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BACKGROUND Statement of problem-Bone loss caused by excessive osteoclast formation is the major mechanism underlying many bone diseases leading to problems in dentistry, affecting the treatment plan and patient's quality of life. Despite many treatment options, a development of novel therapies that are natural, safe, effective and economical is vital for improved strategies against bone loss. Propolis, a natural material that honeybees collect from living plants has been reported to have multiple biological effects including bone loss prevention activities. But there is no systematic review available that has evaluated the effect of propolis on bone loss prevention. MATERIALS AND METHODSThe articles with the clinical and in vitro investigations that assessed the prevention and treatment of bone loss using propolis were selected. Electronic database was searched from 1978 to 2016 using the keywords "Propolis" or "propolis" and "bone loss" or "propolis" and "prevention of bone loss." RESULTS Propolis, which contains a component called Caffeic Acid Phenethyl Ester (CAPE)has an effect on prevention of bone loss. The mechanism of action of CAPE is by inhibiting NF-kappa B and NFAT activation. This in turn results in attenuation of osteoclastogenesis and bone resorption, implying that CAPE can be potential treatment for bone loss prevention. CONCLUSIONThe literature review suggests that the use of propolis can prevent bone loss. However, as most of the studies were in vitro, there is insufficient reliable evidence to truly provide a recommendation regarding this natural compound. A well-designed, randomised controlled trials are needed to provide answers to these questions.

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The Effect of Caffeic Acid on Wound Healing in Skin-incised Mice

Cited by 76 publications

References 22 publications

Caffeic Acid Reduces Cutaneous Tumor Necrosis Factor Alpha (TNF-α), IL-6 and IL-1β Levels and Ameliorates Skin Edema in Acute and Chronic Model of Cutaneous Inflammation in Mice

Caffeic Acid Reduces Cutaneous Tumor Necrosis Factor Alpha (TNF-α), IL-6 and IL-1β Levels and Ameliorates Skin Edema in Acute and Chronic Model of Cutaneous Inflammation in Mice

Anti-allergic Effects of Extracts from Commercial Products of Cooked Burdock

Effect of Propolis on Bone Loss Prevention- A Review

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