The effect of caffeine on chromosome loss and nondisjunction in Drosophila

Mittler, Sidney; Mittler, Jeanne E.; Tonetti, A.M.; Szymczak, Monika

doi:10.1016/0027-5107(67)90058-9

Cited by 12 publications

(1 citation statement)

References 8 publications

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“…However, CLARK & CLARK (I 968) reported significantly more XO males with a corresponding decrease in XXY females from ring X males reared on 0.19 per cent caffeine when mated to yellow females. BATEMAN (1969), trying to duplicate the work of MITTLER et al (1967), reported no significant increase or decrease of XO and XXY progeny from males reared on 0.123 per cent caffeine nor from suspending larvae in 2.0 per cent caffeine in water for twenty-four hours.…”

Section: Introductionmentioning

confidence: 99%

Effects of caffeine on chromosomal loss and nondisjunction in Drosophila melanogaster

Zettle

Murnik

1973

Genetica

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Three types of male larvae, normal X males and two types with structurally abnormal X chromosomes (ring X and short X sc4sc s, y) were treated during the third instar with 0.5 per cent caffeine in nutrient medium. Upon eclosion, these males were mated to yellow and Oregon-R wild type females.The F1 generation of each cross was scored for normal (XX and X¥) and abnormal (XO and XXY) progeny. Statistical analyses of data demonstrate that caffeine increases chromosomal loss for all genotypes tested. The effect of caffeine on nondisjunction, however, is not clear. There are at least marginal increases in all cases when Oregon-R females are used. Slight increase and decreases noted for offspring of yellow females appear to be dependent upon the genotype of the inseminating male.

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Section: Introductionmentioning

confidence: 99%