The effect of calcitonin gene-related peptide on pancreatic blood flow and secretion in conscious dogs

Jin, Chunxiang; Naruse, Satoru; Kitagawa, Motoji; Ishiguro, Hiroshi; Nakajima, M.; Mizuno, Nobumasa; Ko, Shigeru B. H.; Hayakawa, Tetsuo

doi:10.1016/s0167-0115(01)00214-2

Cited by 5 publications

(3 citation statements)

References 37 publications

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“…This is in good agreement with the vascular effect of CGRP in rainbow trout coeliac arteries, where chicken CGRP induced vasorelaxation, and in other vertebrates as distantly related as, e.g., the bullfrog, the crocodile, and the dog (Kline et al 1988;Kågström and Holmgren 1998;Jin et al 2001). Furthermore, a CGRP-antagonist reduces nicotine-induced relaxation in the dorsal aorta of the holocephalan elephant fish, Callorhinchus milii (Jennings et al 2007).…”

Section: Discussionsupporting

confidence: 84%

Cod CGRP and tachykinins in coeliac artery innervation of the Atlantic cod, Gadus morhua: presence and vasoactivity

Shahbazi

Holmgren

Jensen

2008

Fish Physiol Biochem

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The presence and vasoactive effects of native calcitonin gene-related peptide (CGRP), substance P (SP), and neurokinin A (NKA) were studied on isolated small branches of the coeliac artery from Atlantic cod, Gadus morhua, using immunohistochemistry and myograph recordings, respectively. Immunohistochemistry revealed nerve fibers containing CGRP- and SP/NKA-like material running along the wall of the arteries. CGRP induced vasorelaxation of precontracted arteries with a pD(2) value of 8.54 +/- 0.17. Relaxation to CGRP (10(-8) M) was unaffected by L-NAME (3 x 10(-4) M) and indomethacin (10(-6) M) suggesting no involvement of nitric oxide or prostaglandins in the CGRP-induced relaxation. SP and NKA (from 10(-10) to 3 x 10(-7) M) contracted the unstimulated arteries at concentrations from 10(-8) M and above in 42% and 33%, respectively, of the vessels. It is concluded that the innervation of the cod celiac artery includes nerves expressing CGRP-like and tachykinin-like material, and that a vasodilatory response to CGRP is highly conserved amongst vertebrates while the response to tachykinins is more variable.

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Section: Discussionsupporting

confidence: 84%

Cod CGRP and tachykinins in coeliac artery innervation of the Atlantic cod, Gadus morhua: presence and vasoactivity

Shahbazi

Holmgren

Jensen

2008

Fish Physiol Biochem

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“…CGRP has been shown to improve blood flow in experimental settings [6,23] . These findings are in accordance with the results of our study, in which CGRP normalized pancreatitis-associated pancreatic microcirculatory disorders almost back to normal values.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects and Anti-Inflammatory Pathways of Exogenous Calcitonin Gene-Related Peptide in Severe Necrotizing Pancreatitis

et al. 2009

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“…These events result in the sequestration of intracellular Ca 2+ leading to vascular smooth muscle relaxation. This vasodilator effect of VIP has been demonstrated in several organ systems such as the brain (Heistad et al ., 1980), uterus (Clark et al ., 1981), pancreas (Jin et al ., 2001) and skin (Williams, 1982). The recent identification of VPAC receptors in human synovium (Takeba et al ., 1999) is a further indication of VIP involvement in articular vasoregulation; however, confirmation of this physiological role has yet to be established.…”

Section: Introductionmentioning

confidence: 99%

The role of joint nerves and mast cells in the alteration of vasoactive intestinal peptide (VIP) sensitivity during inflammation progression in rats

McDougall

Barin

2005

British J Pharmacology

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1 The present study examined the peripheral effects of vasoactive intestinal peptide (VIP) on rat knee joint blood flow during acute and chronic inflammation. The involvement of joint nerves and synovial mast cells on these effects was also investigated. 2 Prior to blood flow assessment, animals were deeply anaesthetised with ethyl carbamate (urethane; 2 mg kg À1 i.p.). Local application of VIP (10 À13 -10 À9 mol) onto the capsular surface of normal rat knee joints caused a dose-dependent increase in synovial perfusion with an ED 50 of 1.2 Â 10 À11 mol. The dilator effect of the peptide was transient with the maximal response occurring approximately 1 min after drug administration. 3 VIP-induced vasodilatation was blocked by co-administration of the VIP receptor antagonist VIP 6-28 (10 À9 mol). The inhibitory effect of the antagonist was consistent across the entire VIP dose range (P ¼ 0.01). 4 The vasoresponsiveness to VIP was significantly attenuated in acutely inflamed joints; however, surgical denervation of acutely inflamed knees re-established the vasodilator effect of the neuropeptide. 5 Topical application of VIP to 1-and 3-week adjuvant monoarthritic knees produced a hyperaemic response, which was not significantly different from normal (P ¼ 0.06 and 0.73 for 1-and 3-week adjuvant treated joints, respectively). 6 Stabilisation of synovial mast cells by disodium cromoglycate (cromolyn) pretreatment did not alter the vasoresponsiveness to VIP in acute or chronically inflamed joints. 7 The vasodilatatory effect of VIP is lost during acute knee joint inflammation and this abrogated effect is neurally dependent. In the chronic phase of knee joint inflammation, VIP-mediated hyperaemia recovers to normal levels. Synovial mast cells do not influence the vasomotor effects of exogenously applied VIP in inflamed knee joints.

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The effect of calcitonin gene-related peptide on pancreatic blood flow and secretion in conscious dogs

Cited by 5 publications

References 37 publications

Cod CGRP and tachykinins in coeliac artery innervation of the Atlantic cod, Gadus morhua: presence and vasoactivity

Cod CGRP and tachykinins in coeliac artery innervation of the Atlantic cod, Gadus morhua: presence and vasoactivity

Protective Effects and Anti-Inflammatory Pathways of Exogenous Calcitonin Gene-Related Peptide in Severe Necrotizing Pancreatitis

The role of joint nerves and mast cells in the alteration of vasoactive intestinal peptide (VIP) sensitivity during inflammation progression in rats

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