The effect of calcium supplementation on blood pressure in non-pregnant women with previous pre-eclampsia: An exploratory, randomized placebo controlled study

Hofmeyr, G Justus; Seuc, Armando; Betrán, Ana Pilar; Purnat, Tina D; Ciganda, Álvaro; Munjanja, Stephen; Manyame, Sarah; Singata, Mandisa; Fawcus, Sue; Frank, Karlyn; Hall, David; Cormick, Gabriela; Roberts, James M.; Bergel, Eduardo; Drebit, Sharla; Dadelszen, Peter von; Belizán, José M.

doi:10.1016/j.preghy.2015.04.001

Cited by 28 publications

(18 citation statements)

References 17 publications

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“…Both dietary calcium and whey protein have been implicated in blood pressure reduction, albeit with an equivocal evidence base [39,40]. Here we demonstrate that neither calcium citrate nor milk sources of calcium acutely alter blood pressure, whereas whey protein hydrolysate plus milk minerals rich in calcium acutely reduces diastolic blood pressure by ~ 2 mmHg.…”

Section: Discussionmentioning

confidence: 58%

“…Furthermore, heart rate was not measured in the present study, and therefore it is not possible to assess whether a compensatory increase in heart rate was observed in response to the lowering of blood pressure. Nevertheless, other work has demonstrated that whey protein ingestion can acutely lower systolic blood pressure compared to isocaloric maltodextrin ingestion, without any evidence of compensatory increases in heart rate [39]. Longer-term studies are required to assess whether this acute 2 mmHg reduction in blood pressure translates into chronic changes in blood pressure of a meaningful magnitude.…”

Section: Discussionmentioning

confidence: 99%

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Co-ingestion of whey protein hydrolysate with milk minerals rich in calcium potently stimulates glucagon-like peptide-1 secretion: an RCT in healthy adults

et al. 2019

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Purpose To examine whether calcium type and co-ingestion with protein alter gut hormone availability. Methods Healthy adults aged 26 ± 7 years (mean ± SD) completed three randomized, double-blind, crossover studies. In all studies, arterialized blood was sampled postprandially over 120 min to determine GLP-1, GIP and PYY responses, alongside appetite ratings, energy expenditure and blood pressure. In study 1 (n = 20), three treatments matched for total calcium content (1058 mg) were compared: calcium citrate (CALCITR); milk minerals rich in calcium (MILK MINERALS); and milk minerals rich in calcium plus co-ingestion of 50 g whey protein hydrolysate (MILK MINERALS + PROTEIN). In study 2 (n = 6), 50 g whey protein hydrolysate (PROTEIN) was compared to MILK MINERALS + PROTEIN. In study 3 (n = 6), MILK MINERALS was compared to the vehicle of ingestion (water plus sucralose; CONTROL). Results MILK MINERALS + PROTEIN increased GLP-1 incremental area under the curve (iAUC) by ~ ninefold (43.7 ± 11.1 pmol L −1 120 min; p < 0.001) versus both CALCITR and MILK MINERALS, with no difference detected between CALCITR (6.6 ± 3.7 pmol L −1 120 min) and MILK MINERALS (5.3 ± 3.5 pmol L −1 120 min; p > 0.999). MILK MINERALS + PROTEIN produced a GLP-1 iAUC ~ 25% greater than PROTEIN (p = 0.024; mean difference: 9.1 ± 6.9 pmol L −1 120 min), whereas the difference between MILK MINERALS versus CONTROL was small and nonsignificant (p = 0.098; mean difference: 4.2 ± 5.

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Co-ingestion of whey protein hydrolysate with milk minerals rich in calcium potently stimulates glucagon-like peptide-1 secretion: an RCT in healthy adults

et al. 2019

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“…The World Health Organization (WHO) has recommended antenatal calcium supplementation of 1500–2000 mg daily for pregnant women with low dietary calcium intake who are thus at a higher risk for pre-eclampsia [ 16 , 30 ]. However, a large proportion of Bangladeshi pregnant women are at high risk for multiple micronutrient deficiencies including antioxidants [ 18 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

The association between daily 500 mg calcium supplementation and lower pregnancy-induced hypertension risk in Bangladesh

Khanam

Hossain

Mistry

et al. 2018

BMC Pregnancy Childbirth

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BackgroundEvidence suggests that daily supplementation of 1500 to 2000 mg of calcium during pregnancy reduces pregnancy-induced hypertension (PIH). However, the evidence on the efficacy of low-dose calcium supplementation on PIH is limited. This paper assesses the longitudinal correlation between low-dose calcium intake (500 mg daily) and change in blood pressure during pregnancy among a homogeneous population in terms of hypertension and pre-eclampsia.MethodsThe study followed a retrospective cohort study design, and was carried out among 11,387 pregnant women from 10 rural upazilas (sub-districts) of Bangladesh where maternal nutrition initiative (MNI), implemented by Building Resources Across Communities (BRAC), was ongoing. The modified Poisson regression model was used to estimate the association (risk ratio) between consumption of calcium tablets and PIH.ResultsThe present research found that women who consumed 500 mg/d calcium tablets for more than 6 months during their pregnancy had a 45% lower risk of developing hypertension compared to those who consumed less calcium (RR = 0.55, 95% CI = 0.33–0.93).ConclusionsDaily supplementation of 500 mg oral calcium during pregnancy for at least 180 tablets is associated with a considerably reduced risk of PIH, but this study is unable to confirm whether this association is causal. The causal relationship needs to be confirmed through a large scale randomized controlled trial.Electronic supplementary materialThe online version of this article (10.1186/s12884-018-2046-0) contains supplementary material, which is available to authorized users.

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“…Whether differences in calcium metabolism persist in women after pregnancy in the two groups is not clear. Lower calcium intake during pregnancy appears to be associated with increased risk of subsequent development of hypertension especially in women with a history of hypertension in pregnancy (27) and calcium supplementation in women with a history of preeclampsia was reported to lower blood pressure (28). The relationship of calcium to blood pressure may be through decreased production of the vasodilator nitric oxide, as the enzymatic production is calcium dependent (29).…”

Section: Discussionmentioning

confidence: 99%

Pregnancy history, coronary artery calcification and bone mineral density in menopausal women

et al. 2017

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Objective This study examined relationships, by pregnancy histories, between bone mineral density (BMD) and coronary artery calcification (CAC) in postmenopausal women. Methods Forty women identified from their medical record as having preeclampsia (PE) were age/parity-matched with 40 women having a normotensive pregnancy (NP). Vertebral (T04-09) BMD and CAC were assessed by Quantitative Computed Tomography in 73 (n=37 with PE and n=36 with NP) of the 80 women. Analyses included linear regression using generalized estimating equations. Results Women averaged 59 years of age and 35 years from the index pregnancy. There were no significant differences in cortical, trabecular or central BMD between groups. CAC was significantly greater in the PE group (P=0.026). In multivariable analysis, CAC was positively associated with cortical BMD (P=0.001) and negatively associated with central BMD (P=0.036). There was a borderline difference in the association between CAC and central BMD by pregnancy history (interaction, P=0.057). Conclusions Although CAC was greater in women with a history of PE, vertebral BMD did not differ between groups. However, both cortical and central BMD were associated with CAC. The central BMD association was marginally different by pregnancy history suggesting perhaps differences in underlying mechanisms of soft tissue calcification.

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The effect of calcium supplementation on blood pressure in non-pregnant women with previous pre-eclampsia: An exploratory, randomized placebo controlled study

Cited by 28 publications

References 17 publications

Co-ingestion of whey protein hydrolysate with milk minerals rich in calcium potently stimulates glucagon-like peptide-1 secretion: an RCT in healthy adults

Co-ingestion of whey protein hydrolysate with milk minerals rich in calcium potently stimulates glucagon-like peptide-1 secretion: an RCT in healthy adults

The association between daily 500 mg calcium supplementation and lower pregnancy-induced hypertension risk in Bangladesh

Pregnancy history, coronary artery calcification and bone mineral density in menopausal women

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