The effect of CAPE on lipid peroxidation and nitric oxide levels in the plasma of rats following thermal injury

Hoşnuter, Mübin; Gürel, Ahmet; Babucçu, Orhan; Armutçu, Ferah; Kargι, Eksal; Işıkdemir, Ahmet

doi:10.1016/j.burns.2003.09.022

Cited by 112 publications

(83 citation statements)

References 26 publications

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“…The methods in this study were similar to those in previous experimental and clinical burn studies (Hosnuter et al 2004;Han et al 2005;Durmus et al 2009;Yaman et al 2010).…”

Section: Discussionsupporting

confidence: 72%

“…Test animals such as the rat have been used in various studies (Hosnuter et al 2004;Han et al 2005;Gal et al 2008;Durmus et al 2009;Yaman et al 2010;Sabol et al 2012). The model used here is simple and reproducible.…”

Section: Discussionmentioning

confidence: 99%

“…Skin burns were created bilaterally as described by Hosnuter et al (2004), Han et al (2005), Durmus et al (2009) and Yaman et al (2010). Animals were subjected to full-thickness second-degree skin burns with 1 cm surface area diameter with the use of brass probes.…”

Section: Experimental Animals and Protocol Designmentioning

confidence: 99%

“…SSD cream, while being effective, causes some systemic complications including neutropenia, erythaema multiforme, crystalluria and methemoglobinaemia (Gracia 2001;Hosnuter et al 2004;Han et al 2005;Durmus et al 2009). …”

mentioning

confidence: 99%

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Effects of extractum cepae, heparin, allantoin gel and silver sulfadiazine on burn wound healing: an experimental study in a rat model

Durmuş¹,

Yaman²,

Can³

2012

Vet. Med. - Czech

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ABSTRACT:These experiments were conducted in order to compare the effects of extractum cepae, heparin, allantoin gel (CTBX) and silver sulfadiazine (SSD) cream on burn wound healing in rats. Thirty six adult, female Wistar albino rats were divided into three equal groups. A burn was made on the back of all rats. The burned areas in the first, second and third groups were covered with cold cream (control), SSD skin cream and CTBX twice a day, respectively. Seven and 14 days later, the rats were sacrificed and burned skin tissue samples were collected from the rats for histopathological examinations. Histopatological evaluations on the 7 th and 14 th daysshowed burn healing to be better in the CTBX and SSD groups with respect to the control group. The best burn wound healing was observed in the CTBX group (P < 0.001). Wound healing was significantly different between the groups at days 7 and 14 (P < 0.001). In conclusion, application of CTBX has significant positive effects on the healing of burn wounds in a rat model.

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“…The methods in this study were similar to those in previous experimental and clinical burn studies (Hosnuter et al 2004;Han et al 2005;Durmus et al 2009;Yaman et al 2010).…”

Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Experimental Animals and Protocol Designmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Effects of extractum cepae, heparin, allantoin gel and silver sulfadiazine on burn wound healing: an experimental study in a rat model

Durmuş¹,

Yaman²,

Can³

2012

Vet. Med. - Czech

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“…Antioxidant matters added to diet in order to support the protective activity of the antioxidant defense systems have a vital role (SEVEN et al 2010). It is known that vitamin E show antioxidant characteristics to the oxidants in the cell membrane and another compound in the structure of propolis, caffeic acid phenethyl ester (CAPE), blocks the production of reactive oxygen types (SEVEN et al 2010, HOSNUTER et al 2004. Vitamin E (␣-tocopherol) function as biological antioxidants to protect cellular macromolecules (DNA, protein, lipids) and other antioxidant molecules from uncontrolled oxidation by free radicals during normal metabolism or under the conditions of oxidative challenge such as infection, stress, and pollution (HUANG & HUANG 2004, RUFF et al 2002.…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary propolis and vitamin E on growth performance and antioxidant status in blood of juvenile Rainbow trout, Oncorhynchus mykiss (Teleostei: Salmoniformes) under different flow rates

Keleştemur¹,

Seven²,

Yılmaz³

2012

Zoologia (Curitiba)

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The present study investigated the effects of propolis and vitamin E supplementation in diets of juvenil rainbow trout subjected to two different flow rates with or without flow stress (0.9 and 2.1 l/min, respectively) on final weigth (FW), condition factor (CF), feed conservation ratio (FCR), protein efficiency ratio (PER) and vitamin A, C and E concentrations and malondialdehyde (MDA) levels in serum as well as plasma superoxide dismutase (SOD) activity. The experimental groups were as follows: group C was fed a basal diet, group P10 was fed a basal diet supplemented with 10 g propolis/kg, group P30 was fed a basal diet supplemented with 30 g propolis/kg, group E60 was fed a basal diet supplemented with 60 mg vitamin E/kg. CF and PER were not different among all diets groups for both flow rate treatments (p > 0.05). The FCR improved in P10, P30 and E60 diet groups compared to C diet group at 2.1 l/min flow rate (p < 0.05). The FCR of E60 and P30 were found to be better than C and P10 diet groups at 0.9 l/min flow rate (p < 0.05). Vitamin E and propolis supplementations did not affect vitamin A concentration of serum for either flow rate (p > 0.05). Fish fed with diet E60had higher serum vitamin E concentration than other groups (p < 0.05). Serum Vitamin C concentration was only affected by the propolis supplemented diets. MDA level of E60 group was found significantly lower comperad to other groups for both flow rate (p < 0.05). Plasma SOD activity significantly decreased in the E60 group compared to other groups at 2.1 l/min flow rate (p < 0.05). But plasma SOD activity was not different among all diets groups at 0.9 l/min flow rate (p > 0.05)

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Propolis prevents inhibition of apoptosis by potassium bromate in CCD 841 human colon cell

Memmedov

Oktay

Durmaz

et al. 2020

Cell Biochemistry & Function

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Previously, we demonstrated that biotransformation of propolis by some special strains of Lactobacillus plantarum might decrease the allergenic molecules in propolis.In this study, we aimed to investigate the effect of biotransformation of propolis on its antioxidant effect and its protective effect against potassium bromate-induced cancer in human colon cell line. Propolis samples were treated with different solutions (ethanol, polyethylene glycol, and water), and ultrasonication was applied at 40 Hz (5, 10, and 15 minutes) in order to facilitate solvation of solid samples. Fermentations were performed by L. plantarum strains (ISLG-2, ATCC-8014, and Visbyvac). The phenolic content of propolis was determined with liquid chromatography-mass spectrometry/mass spectrometry (LCMS/MS). The antioxidant activity (antioxidant enzymes, lipid peroxidation) and apoptosis markers (caspase 3,8,9, cytochrome-c, tumour necrosis factor-related apoptosis-inducing ligand-R1 and R2 [TRAIL], and apoptosis protease activating factor-1 [APAF-1] levels) were determined in CCD 841-human colon cell line after induction of oxidative stress by potassium bromate. All propolis samples in different solvents induced apoptosis and 4 biotransformed (by L. plantarum ISL-2 strain and L. plantarum ATCC 8014 strain) propolis samples with low allergenic molecules demonstrated similar inductions of apoptosis in CCD841 cell line.In conclusion, reduction of allergenic molecules in propolis via biotransformation did not change the antioxidant and protective effects of propolis, and it is suggested as a potential therapeutic molecule in prevention of colon cancer caused by oxidative stress for all patients.Significance of the study: This study is the first investigation that shows protective effect of propolis against potassium bromate toxicity by means of decreasing lipid peroxidation and reversing the main molecule levels in intrinsic and extrinsic pathway of apoptosis. Biotransformed propolis samples by L. plantarum ISL-2 and ATCC 8014 strain with low allergen molecule content has also the same effect in potassium bromate toxicity in CCD841 colon cell. Our data contributed that propolis as a natural

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The effect of CAPE on lipid peroxidation and nitric oxide levels in the plasma of rats following thermal injury

Cited by 112 publications

References 26 publications

Effects of extractum cepae, heparin, allantoin gel and silver sulfadiazine on burn wound healing: an experimental study in a rat model

Effects of extractum cepae, heparin, allantoin gel and silver sulfadiazine on burn wound healing: an experimental study in a rat model

Effects of dietary propolis and vitamin E on growth performance and antioxidant status in blood of juvenile Rainbow trout, Oncorhynchus mykiss (Teleostei: Salmoniformes) under different flow rates

Propolis prevents inhibition of apoptosis by potassium bromate in CCD 841 human colon cell

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