1993
DOI: 10.1111/j.1365-2125.1993.tb04178.x
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The effect of captopril on the superior mesenteric artery and portal venous blood flow in normal man.

Abstract: 1. Measurements of superior mesenteric artery and portal venous blood flow were made non‐invasively along with systemic and other regional (cardiac index, forearm and cutaneous blood flow) vascular responses to acute ingestion of the ACE inhibitor captopril (50 mg) or placebo (50 mg vitamin C), in 12 healthy subjects while supine and during head‐up tilt. 2. After captopril, superior mesenteric artery and portal blood flow rose markedly with a reduction in superior mesenteric artery vascular resistance. Supine … Show more

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Cited by 14 publications
(15 citation statements)
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“…It is thought that the differential increase in sympathetic nervous activity of each organ in the abdomen leads to the different local vascular response in splanchnic organs, and angiotensin (ANG) II is then thought to play a major role in the regulation of splanchnic blood flow during exercise in humans (1,11,26,35,36). However, ANG II may not be the main factor in the regulation of abdominal blood flow because the duration of the cycling exercise in the present study was short and, therefore, it is more likely that blood flow to these organs is sympathetically controlled by the central nervous system (11,16,17,22,29,39).…”
Section: Discussionmentioning
confidence: 99%
“…It is thought that the differential increase in sympathetic nervous activity of each organ in the abdomen leads to the different local vascular response in splanchnic organs, and angiotensin (ANG) II is then thought to play a major role in the regulation of splanchnic blood flow during exercise in humans (1,11,26,35,36). However, ANG II may not be the main factor in the regulation of abdominal blood flow because the duration of the cycling exercise in the present study was short and, therefore, it is more likely that blood flow to these organs is sympathetically controlled by the central nervous system (11,16,17,22,29,39).…”
Section: Discussionmentioning
confidence: 99%
“…Angiotensin II acting on Ang II type 1 (AT 1 ) receptors also appears continuously to regulate the renal blood flow and vascular resistance of rats with aortocaval fistula shortly after fistula creation (Brodsky et al 1998). However, in healthy humans and those with heart failure, Ang II continuously regulates blood flow through the superior mesenteric artery, but not the renal artery (Ray-Chaudhuri et al 1993;Houghton et al 1999).…”
Section: Introductionmentioning
confidence: 99%
“…First, ACE-I reduced gastric mHbO 2 . The RAAS is known to reduce mesenteric perfusion (McNeill et al 1977, Bulkley et al 1985, Bailey et al 1986, Reilly et al 1997, and inhibition of the RAAS during captopril therapy increased blood flow in the superior mesenteric artery (Ray-Chaudhuri et al 1993). Similar effects are observed during long-term treatment (Rozsa & Sonkodi 1995) and in critically ill trauma patients (Kincaid et al 1998).…”
Section: Interpretation Of the Resultsmentioning
confidence: 73%