The effect of carbon monoxide releasing molecule-2 (CORM-2) on healing of ischemic  colon anastomosis in rats

Kayapinar, Ali Kemal; Ercan, Metin; Baş, Kadir Koray; Yamak, Seda; Erçin, Uğur; Türkoğlu, Mehmet Akif; Bostancı, Erdal Birol

doi:10.3906/sag-1902-43

Cited by 3 publications

(1 citation statement)

References 38 publications

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“…Ischaemia was induced with ligation or electrocauterization of a wide segment of rat’s left colon just above the pubic symphysis. The different kinds of intervention attempted are shown in Table 1 [ 20 - 40 ].…”

Section: Resultsmentioning

confidence: 99%

Experimental models of high-risk bowel anastomosis in rats: A systematic review

Ntampakis,

Pramateftakis,

Anestiadou

et al. 2024

World J Exp Med

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BACKGROUND Anastomotic leaks remain one of the most dreaded complications in gastrointestinal surgery causing significant morbidity, that negatively affect the patients’ quality of life. Experimental studies play an important role in understanding the pathophysiological background of anastomotic healing and there are still many fields that require further investigation. Knowledge drawn from these studies can lead to interventions or techniques that can reduce the risk of anastomotic leak in patients with high-risk features. Despite the advances in experimental protocols and techniques, designing a high-quality study is still challenging for the investigators as there is a plethora of different models used. AIM To review current state of the art for experimental protocols in high-risk anastomosis in rats. METHODS This systematic review was performed according to The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. To identify eligible studies, a comprehensive literature search was performed in the electronic databases PubMed (Medline) and Scopus, covering the period from conception until 18 October 2023. RESULTS From our search strategy 102 studies were included and were categorized based on the mechanism used to create a high-risk anastomosis. Methods of assessing anastomotic healing were extracted and were individually appraised. CONCLUSION Anastomotic healing studies have evolved over the last decades, but the findings are yet to be translated into human studies. There is a need for high-quality, well-designed studies that will help to the better understanding of the pathophysiology of anastomotic healing and the effects of various interventions.

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Section: Resultsmentioning

confidence: 99%