The effect of cathepsin K inhibitor surface treatment on delayed tooth replantation in dogs

Kwon, Y.; Ko, Hyunjung; Kim, Soojung; Kim, Miri

doi:10.1111/edt.12397

Cited by 6 publications

(8 citation statements)

References 26 publications

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“…Furthermore, several substances have been used for the treatment of the root surface of replanted teeth to increase their retention rate, namely, formol, acid solutions (such as citric acid, hydrochloric acid, acidulated fluoride, and neutral fluoride), alkaline substances (such as calcium hydroxide and NaOCl), antibiotics (such as tetracycline and rifocin), antibiotic/corticosteroid combination, corticosteroid, alendronate, Vitamin C, carbonic anhydrase inhibitor (acetazolamide), Cathepsin K, propolis, and Emdogain (21,22).…”

Section: Discussionmentioning

confidence: 99%

Delayed reimplantation of an avulsed central incisor: a 12-year follow-up

Özkan¹

2021

Turk Endod J

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The present case highlights the 12-year follow-up of delayed replantation of a maxillary central incisor which was avulsed due to trauma. The complications seen in the present case were ankylosis and replacement resorption. Clinically, the tooth was asymptomatic and in infraocclusion; however, esthetics was maintained. Information on the long-term outcome and prognosis of surface treatment by the application of tetracycline HCl is lacking and this case report highlights the result of root surface treatment with tetracycline HCl.

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Section: Discussionmentioning

confidence: 99%

Delayed reimplantation of an avulsed central incisor: a 12-year follow-up

Özkan¹

2021

Turk Endod J

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“…Attempts have been made to facilitate greater pulp and periodontal healing, and greater lifetime of the replanted teeth. Thymosin alpha 1, enamel matrix derivative, fibroblast growth factor, triamcinolone, bisphosphonates dexamethasone, 3Mix (the mixture of ciprofloxacin, metronidazole, and minocycline), Cathepsin K inhibitor and fluoride are medicines tried in different models to provide short-term and long-term benefits in the replantation of avulsed teeth [ 13 – 22 ]. They might exert their beneficial effect on replanted teeth by inhibiting the activity of osteoclasts, controlling the inflammation through decreased C-reactive protein, or favoring the formation of new periodontal ligament.…”

Section: Introductionmentioning

confidence: 99%

Effect of tetracyclines on pulpal and periodontal healing after tooth replantation: a systematic review of human and animal studies

et al. 2021

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Background Pulpal and periodontal healing are two main concerns of delayed replantation of avulsed teeth. The objective of this review was to evaluate the effectiveness of topical and systemic application of tetracyclines on pulpal and periodontal healing after tooth replantation. Methods A comprehensive electronic search was conducted in six databases. This systematic review was carried out according to Cochrane Handbook and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Results After exclusion of 246 irrelevant papers, 14 animal studies and one human study were included in this review. The human study showed that avulsed permanent teeth treated with doxycycline did not show a better clinical outcome for pulp and periodontal healing compared with treatment with normal saline. As for animal studies, significant more pulpal healing was observed in immature teeth treated with topical doxycycline in two researches, while another one study showed that there is no difference between teeth treated with normal saline and teeth treated with doxycycline. Systemic doxycycline exerted no significant effect on pulpal revascularization illustrated by one research. Only one out of four articles illustrated the positive effect of systemic tetracyclines on periodontal healing. One paper reported that intracanal application of demeclocycline promoted favorable periodontal healing. Two articles showed topical doxycycline contributed to favorable periodontal healing, while five studies showed no significant effect of topical tetracyclines on periodontal healing. Conclusions As a result of data heterogeneity and limitations of the studies, the effect of topical or systemic application of tetracyclines on pulpal and periodontal healing is inconclusive. More studies are required to get more clinically significant conclusions.

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“…Osteoclasts are found in several stages of root resorption and cathepsin K is one of the key markers of osteoclastic activity. Previous studies suggested that inhibition of cathepsin K downregulated IL-1, IL-17, and TNFα expression via the RANKL pathway on delayed tooth replantation in dog models 39.…”

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confidence: 95%

Effect of intra‐alveolar delivery of Frondoside A on inflammatory response of delayed tooth replantation

Herr,

Ye,

Kang

et al. 2023

Dental Traumatology

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Background/AimFrondoside A is a sea cucumber extract which is well known for its anti‐inflammatory and immunomodulatory properties. The purpose of this study was to evaluate the effect of Frondoside A application in the alveolar socket on inflammatory responses after delayed replantation in rat teeth.Materials and MethodsHuman periodontal ligament cells were cultured and exposed to Frondoside A. Cell‐counting kit‐8 assay was performed to evaluate the cell viability and nitric oxide assay was performed to assess the anti‐inflammatory effect of Frondoside A. Molars were extracted from 32 Sprague–Dawley rats and randomly divided into control and Frondoside A groups. After 30 min of extra‐oral dry time, molars were replanted. In the Frondoside A group, Frondoside A solution was applied in the alveolar socket before replantation. The animals were sacrificed after 28 days and histologically and immunohistochemically evaluated.Results0.5 μM Frondoside A showed higher cellular viability at 6 h and lower production of nitric oxide compared with other Frondoside A solutions (p < .05). The Frondoside A group demonstrated lower inflammatory resorption scores in both middle 1/3 and apical 1/3 of root compared to the control group (p < .05). The Frondoside A group showed lower levels of expression in both cathepsin K and CD45 compared with the control group (p < .05).ConclusionsWithin the limits of this study, intra‐alveolar delivery of Frondoside A alleviates inflammatory root resorption in delayed replantation of rat teeth.

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The effect of cathepsin K inhibitor surface treatment on delayed tooth replantation in dogs

Abstract: Cathepsin K inhibitor did not demonstrate significant inhibitory effects on root resorption after delayed replantation in vivo.

Cited by 6 publications

References 26 publications

Delayed reimplantation of an avulsed central incisor: a 12-year follow-up

Delayed reimplantation of an avulsed central incisor: a 12-year follow-up

Effect of tetracyclines on pulpal and periodontal healing after tooth replantation: a systematic review of human and animal studies

Effect of intra‐alveolar delivery of Frondoside A on inflammatory response of delayed tooth replantation

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