The effect of celery (Apium graveolens L.) on fertility: A systematic review

Abstract

Background Fertility and infertility problems are among the complex issues in medicine. The use of herbal products in the treatment of fertility has been considered as an alternative to synthetic drugs. Celery containing known compounds can have an impact on the fertility rate. The aim of this study was to do a systematic review on conducted studies in conjunction with the celery and reproduction. Methods Required papers were searched from databases like Science direct, PubMed, Scopus, and Springer. Keywords used in this study were "Apium graveolens L.", "fertility", "reproductive system", "sperm", "testis", "delivery", "sexual hormone", "LH", "FSH", "testosterone", "semen", "male", and "female". Out of 238 collected articles (published in the period 1995 to 2015), 222 were excluded due to non-relevance and lack of access to the original article. Results The notable points were the different results seen by different researchers during different treatment periods or at different doses. Of the 16 studies reviewed in this study, 13 studies have mentioned the positive effect of celery on fertility, while three studies reported the inhibitory effects of this plant. Conclusions Celery can have protective effects against substances such as sodium valproate, propylene glycol, and diethyl phthalate causing damages to the testicular structure and spermatogenesis. In this regard, the doses used and the treatment time while using the plant must be accurately investigated. Since there are compounds such as apigenin, the celery can induce inhibitory effects on fertility in case of chronic use or high concentration.

Apium Plants: Beyond Simple Food and Phytopharmacological Applications

“…Similarly, the aqueous extract of the leaves was observed to improve the spermatogenesis process and could be useful for some sperm fertility parameters [126]. In another study, hydroalcoholic extract of the plant was shown to boost spermatogenesis and, as indicated by this study, celery can have a protective effect against substances that cause damage to the testicular structure and spermatogenesis [199].…”

The Genus Adonis as an Important Cardiac Folk Medicine: A Review of the Ethnobotany, Phytochemistry and Pharmacology

“…As well as two reviews published by Kooti et al (2016, 2018), in this review we searched the information on this genus from databases (using Elsevier, ACS, Springer, Wiley, Nature, RSC, Medline Plus, Bentham Science, Hindawi Science, CNKI, VIP, Web of Science, Google Scholar and Baidu Scholar) and libraries, and the search languages were set to English and Chinese. We didn’t set the time period for searching more literatures.…”

Cytoprotective Antioxidant, Anti-Inflammatory, and Antifibrotic Impact of Celery Seed Oil and Manuka Honey Against Cyclophosphamide-Induced Cystitis in Rabbits

“…Although it is effective for treating induced HC; however, it cannot wholly eradicate the challenging symptoms of HC in 25% of CP-treated cases [9]. erefore, it is essential to involve other protective antioxidant agents such as celery seed oil (CSO) or manuka honey (MH) beside mesna to reduce the hazards of induced HC [10,11]. Numerous studies focused on celery (Apium graveolens) and honey as effective antioxidants, which substantially reduced the cellular oxidative damage [12,13].…”