Honey Bee Colony Losses AbstractHoney bees not only produce the honey and hive products (propolis, pollen, royal jelly and wax) but also they are one of the most effective pollinators that are required for the realization of agricultural production in the world. In this manner, they have a fundamental role in global agricultural economy and production. The recent reports from various studies emphasized the unexplained losses of bee colonies in many countries and many governments have started to concern future effects of this occasion . Sudden disappearance of worker bees, dead bees in front of the hive, low number of adult bees, less produced honey and low pollinated crops are the symptoms which is described as colony collapse disorder (CCD). Colony losses seem to be driven by many factors such as pesticides, guttation water, pathogens, pests, global warming, cell phone radiation and stress factors. This review focuses on the reasons of honey bee decline and the potential solutions to shed light to honey bee disappearence.