The effect of central administration of alpha‐pinene on capsaicin‐induced dental pulp nociception

Rahbar, I.; Abbasnejad, Mehdi; Haghani, Jahangir; Raoof, Maryam; Kooshki, Razieh; Esmaeili‐Mahani, Saeed

doi:10.1111/iej.13006

Cited by 29 publications

(31 citation statements)

References 41 publications

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“…The impact of α-pinene on pulpal pain in Wistar mice was investigated [78]. Selected mice were cannulated by their lateral ventricles for capsaicin (100 µg) supplementation.…”

Section: Preclinical Pharmacological Activities Of α- and β-Pinenementioning

confidence: 99%

Therapeutic Potential of α- and β-Pinene: A Miracle Gift of Nature

et al. 2019

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α- and β-pinene are well-known representatives of the monoterpenes group, and are found in many plants’ essential oils. A wide range of pharmacological activities have been reported, including antibiotic resistance modulation, anticoagulant, antitumor, antimicrobial, antimalarial, antioxidant, anti-inflammatory, anti-Leishmania, and analgesic effects. This article aims to summarize the most prominent effects of α- and β-pinene, namely their cytogenetic, gastroprotective, anxiolytic, cytoprotective, anticonvulsant, and neuroprotective effects, as well as their effects against H2O2-stimulated oxidative stress, pancreatitis, stress-stimulated hyperthermia, and pulpal pain. Finally, we will also discuss the bioavailability, administration, as well as their biological activity and clinical applications.

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“…The impact of α-pinene on pulpal pain in Wistar mice was investigated [78]. Selected mice were cannulated by their lateral ventricles for capsaicin (100 µg) supplementation.…”

Section: Preclinical Pharmacological Activities Of α- and β-Pinenementioning

confidence: 99%

Therapeutic Potential of α- and β-Pinene: A Miracle Gift of Nature

et al. 2019

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“…Superoxide dismutase, catalase, peroxidase, NO, IL-6 [155] C57BL/6 mice CD4, CD8 and NK cells [102] Wistar rats COX2 [156]…”

Section: Anti-inflammatory Antioxidantmentioning

confidence: 99%

“…Sprague-Dawley rats Sleep rhythm [157] Mice BDNF, TH, EPM test [158] ICR and C57BL/6N mice GABA BZD receptor, sleep behavior [159] Wistar-Kyoto mice Forced swim test, oxidative phosphorylation expression [160] Wistar rats Sensorimotor severity score [155] C57BL/6 mice Schizophrenia-like behavior [161] Analgesic BALB/c mice Tail-flick test [162] Mice Neuropathic pain [163] Wistar rats Nociception [156] Abbreviations: BDNF, brain-derived neurotrophic factor; BZD, benzodiazepine; EPM, elevated plus maze; ERK, extracellular signal-regulated kinase; GABA, γ-aminobutyric acid; Ig-E, immunoglobulin E; JNK, c-jun N-terminal kinase; MMP-1, metalloproteinase 1; MMP-13, metalloproteinase 13; NF-kB, nuclear factor-B; ROS, reactive oxygen species; TH, tyrosine hydroxylase.…”

Section: Antidepressant Sedativementioning

confidence: 99%

Forest Volatile Organic Compounds and Their Effects on Human Health: A State-of-the-Art Review

Antonelli

Donelli

Barbieri³

et al. 2020

IJERPH

146

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The aim of this research work is to analyze the chemistry and diversity of forest VOCs (volatile organic compounds) and to outline their evidence-based effects on health. This research work was designed as a narrative overview of the scientific literature. Inhaling forest VOCs like limonene and pinene can result in useful antioxidant and anti-inflammatory effects on the airways, and the pharmacological activity of some terpenes absorbed through inhalation may be also beneficial to promote brain functions by decreasing mental fatigue, inducing relaxation, and improving cognitive performance and mood. The tree composition can markedly influence the concentration of specific VOCs in the forest air, which also exhibits cyclic diurnal variations. Moreover, beneficial psychological and physiological effects of visiting a forest cannot be solely attributed to VOC inhalation but are due to a global and integrated stimulation of the five senses, induced by all specific characteristics of the natural environment, with the visual component probably playing a fundamental role in the overall effect. Globally, these findings can have useful implications for individual wellbeing, public health, and landscape design. Further clinical and environmental studies are advised, since the majority of the existing evidence is derived from laboratory findings.

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“…In this context, α-pinene exhibited significantly anti-inflammatory and analgesic effects through inhibition of COX-2. Moreover, the analgesic effect of α-pinene on capsaicin-induced pulp nociception was blocked by co-administration with bicuculline or naloxone, thus suggesting that this effect could be mediated, at least in part, by interaction with GABA-A and µ-opioid receptors [163].…”

Section: Alpha (α)-And β-Pinenementioning

confidence: 99%

“…In this sense, another study showed that α-pinene was also able to inhibit human hepatoma tumor progression by inducing G2/M phase cell cycle arrest [162]. Regarding α-pinene antinociceptive effects, it was previously demonstrated its beneficial potential in capsaicin-induced dental pulp nociception [163], xylene-induced ear edema, and formalin-inflamed hind paw models [164]. In this context, α-pinene exhibited significantly anti-inflammatory and analgesic effects through inhibition of COX-2.…”

Section: Alpha (α)-And β-Pinenementioning

confidence: 99%

Terpenoids, Cannabimimetic Ligands, beyond the Cannabis Plant

et al. 2020

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Medicinal use of Cannabis sativa L. has an extensive history and it was essential in the discovery of phytocannabinoids, including the Cannabis major psychoactive compound—Δ9-tetrahydrocannabinol (Δ9-THC)—as well as the G-protein-coupled cannabinoid receptors (CBR), named cannabinoid receptor type-1 (CB1R) and cannabinoid receptor type-2 (CB2R), both part of the now known endocannabinoid system (ECS). Cannabinoids is a vast term that defines several compounds that have been characterized in three categories: (i) endogenous, (ii) synthetic, and (iii) phytocannabinoids, and are able to modulate the CBR and ECS. Particularly, phytocannabinoids are natural terpenoids or phenolic compounds derived from Cannabis sativa. However, these terpenoids and phenolic compounds can also be derived from other plants (non-cannabinoids) and still induce cannabinoid-like properties. Cannabimimetic ligands, beyond the Cannabis plant, can act as CBR agonists or antagonists, or ECS enzyme inhibitors, besides being able of playing a role in immune-mediated inflammatory and infectious diseases, neuroinflammatory, neurological, and neurodegenerative diseases, as well as in cancer, and autoimmunity by itself. In this review, we summarize and critically highlight past, present, and future progress on the understanding of the role of cannabinoid-like molecules, mainly terpenes, as prospective therapeutics for different pathological conditions.

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The effect of central administration of alpha‐pinene on capsaicin‐induced dental pulp nociception

Abstract: Pinene exhibited significant curable effects on capsaicin-induced pulpal nociception and inflammation mainly via pharmacological interfacing with GABA and μ-opioid receptors.

Cited by 29 publications

References 41 publications

Therapeutic Potential of α- and β-Pinene: A Miracle Gift of Nature

Therapeutic Potential of α- and β-Pinene: A Miracle Gift of Nature

Forest Volatile Organic Compounds and Their Effects on Human Health: A State-of-the-Art Review

Terpenoids, Cannabimimetic Ligands, beyond the Cannabis Plant

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