The Effect of Certain Carcinogens on Vitamin A in the Liver

Baumann, C. A.; Foster, E.G.; Lavik, Paul S.

doi:10.1093/jn/21.5.431

Cited by 16 publications

(4 citation statements)

References 29 publications

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“…(c) The Concentrations of Vitamin A in the Liver: The effect of the administration of dibenzanthracene on the hepatic store of vitamin A is essentially that obtained by Goerner (1) and by Baumann (2,3). Even at the end of 4 weeks, when each of the rats of groups C and D had received only 12 mg. of the car- Group A received basal diet alone; group B received diet and 200 u.s.P, units of vitamin A per rat, per day; group C received diet and 3 mg. of dibenzanthracene per rat, per week; group D received diet and 200 u.s.P, units of vitamin A per rat, per day, and 3 mg. of dibenzanthracene per rat, per week.…”

Section: (B) Liver Weight and Ratio Of Liver Weight To Body Weight (Lw/bw)mentioning

confidence: 85%

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Hepatic Vitamin a in the Rat as Affected by the Administration of Dibenzanthracene

Abels

Gorham

Eberlin

et al. 1942

Journal of Experimental Medicine

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1. The decreased concentrations of vitamin A in the livers of rats given dibenzanthracene probably are due to a particular effect of the carcinogen on the ability of the liver to store the vitamin and not to the production of general hepatic dysfunction. 2. The administration of dibenzanthracene to normal rats does not (a) increase significantly their hepatic content of total fat nor decrease that of phospholipid; (b) impair the ability of their livers to fabricate serum albumin; (c) impair the capacity of their livers to esterify cholesterol or phenol; (d) interfere with the hepatic synthesis and conjugation of glucuronic acid; or (e) interfere with the hepatic storage of riboflavin. 3. The simultaneous ingestion of yeast by the dibenzanthracene-treated rats further depletes their hepatic stores of vitamin A. This depletion conceivably is due to the fact that yeast alone also might deplete the liver of its vitamin A and thus a summation of two similar effects is attained. 4. The results suggest a competition between vitamin A and dibenzanthracene for some substance, possibly a protein, to which vitamin A may be bound in the liver.

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Section: (B) Liver Weight and Ratio Of Liver Weight To Body Weight (Lw/bw)mentioning

confidence: 85%

“…The methods used have been described previously by the authors (7,11). 2. Total protein, albumin, and globulin of the serum and liver.…”

Section: Methodsmentioning

confidence: 99%

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Hepatic Vitamin a in the Rat as Affected by the Administration of Dibenzanthracene

Abels

Gorham

Eberlin

et al. 1942

Journal of Experimental Medicine

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“…To follow changes in the hepatic vitamin A content of rats, two groups of animals received intraperitoneal injections at regular intervals of methylcholanthrene and 3:4-benzpyrene dissolved in lard. (Goerner & Goerner [1939] and Baumann, Foster & Lavik [1941] have shown that carcinogens cause a lowering of the hepatic vitamin A content of rats. )…”

Section: Figmentioning

confidence: 99%

Microdetermination of vitamin A and carotenes

Urban¹,

Milder²,

Carruthers

1943

Biochemical Journal

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On the epidemiology of nasopharyngeal carcinoma

Clifford

1970

Intl Journal of Cancer

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The incidence of nasopharyngeal carcinoma is high in Chinese in South East China and in those living in a traditional Chinese manner in the countries of South East Asia. The related Mongoloid peoples of Japan and Korea have a low incidence, as do the Caucasians of Europe, America and India. In Chinese born abroad and living in a “Western”‐type environment in Australia, Hawaii and California the incidence falls significantly. This suggests that the high incidence in the Chinese relates to a genetically determined racial or “line” predisposition combined with environmental factors or to environmental factors alone. In Kenya, ethnic origin does not relate to incidence which depends on environmental factors only. The possible significance of genetic factors cannot be assessed until adequate information on the genetic profiles of racial groups with high and low incidences is available. Different environmental factors may be of importance. Biologic agents such as fungi or viruses may be of importance in some areas, in others a physical or chemical agent may be of significance, or the cancer may arise following exposure to a combination of factors. In some areas inhalation of polynuclear hydrocarbons may be of importance, in others the ingestion of nitrosamine‐like compounds, and these external agents may only be effective if combined with a viral infection, possibly the Epstein‐Barr virus or with a particular nutritional or hormonal status. The local tissue sensitivity is the factor which determines the response to any particular external agent. Examination of the external environment is, perhaps, of less importance than that of the milieu intérieur, as it is now recognized that the stability of the respiratory epithelium is affected by hormonal and nutritional factors. Universally the incidence in men is higher than in women, and this may relate to their different internal environments.

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The Effect of Certain Carcinogens on Vitamin A in the Liver

Cited by 16 publications

References 29 publications

Hepatic Vitamin a in the Rat as Affected by the Administration of Dibenzanthracene

Hepatic Vitamin a in the Rat as Affected by the Administration of Dibenzanthracene

Microdetermination of vitamin A and carotenes

On the epidemiology of nasopharyngeal carcinoma

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