The effect of Chinese herbal formulas combined with metformin on modulating the gut microbiota in the amelioration of type 2 diabetes mellitus: A systematic review and meta-analysis

Yun-xi, XU; Zheng, Shuyu; Jiang, Shui; Chen, Junyu; Zhu, Xiongwei; Zhang, Ya

doi:10.3389/fendo.2022.927959

Cited by 2 publications

(2 citation statements)

References 97 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Metformin has been found to increase the abundance of Lactobacillus in rodents with HFD (Zhou et al, 2016;Bauer et al, 2018). In recent studies, this trend has also been observed in certain clinical studies in patients with T2DM (Xu et al, 2022).…”

Section: Regulation Of Lactobacillus By Metforminmentioning

confidence: 55%

Advances in the mechanism of metformin with wide-ranging effects on regulation of the intestinal microbiota

Wang,

Jia,

Cong

2024

Front. Microbiol.

View full text Add to dashboard Cite

Metformin is of great focus because of its high safety, low side effects, and various effects other than lowering blood sugar, such as anti-inflammation, anti-tumor, and anti-aging. Studies have shown that metformin has a modulating effect on the composition and function of the intestinal microbiota other than acting on the liver. However, the composition of microbiota is complex and varies to some extent between species and individuals, and the experimental design of each study is also different. Multiple factors present a major obstacle to better comprehending the effects of metformin on the gut microbiota. This paper reviews the regulatory effects of metformin on the gut microbiota, such as increasing the abundance of genus Akkermansia, enriching short-chain fatty acids (SCFAs)-producing bacterial genus, and regulating gene expression of certain genera. The intestinal microbiota is a large and vital ecosystem in the human body and is considered to be the equivalent of an “organ” of the human body, which is highly relevant to human health and disease status. There are a lot of evidences that the gut microbiota is responsible for metformin’s widespread effects. However, there are only a few systematic studies on this mechanism, and the specific mechanism is still unclear. This paper aims to summarize the possible mechanism of metformin in relation to gut microbiota.

show abstract

Section: Regulation Of Lactobacillus By Metforminmentioning

confidence: 55%

Advances in the mechanism of metformin with wide-ranging effects on regulation of the intestinal microbiota

Wang,

Jia,

Cong

2024

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

“…One additional potential causal mechanism through which dietary fibre may influence glycaemic control is through providing substrates for gut microbial fermentation, leading to greater concentrations of SCFAs, which stimulate release of GLP-1, thus improving glycaemic control. A systematic review of dietary interventions [23], some of which could be classed as high fibre diets, on glycaemic control and gut microbial species diversity, composition, and function, in people with T2D found 12 RCTs ranging from 18 days to 3 years in duration. Improvements in HbA1c, fasting blood glucose, total cholesterol, inflammatory markers, and gut microbiota composition from baseline to the end of follow-up were seen within the high fibre intervention groups, but not when compared to the control diets.…”

Section: Fibre and Glycaemic Controlmentioning

confidence: 99%

Role of dietary fibres in cardiometabolic diseases

Dahm,

Langmann,

Nannsen

et al. 2024

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

View full text Add to dashboard Cite

Purpose of review This review highlights recent developments in understanding the role of dietary fibre and specific fibre types on risk and management of cardiometabolic disease with a focus on the causal pathways leading to cardiometabolic diseases, namely weight management, glycaemic control, and lipid levels, as well as the latest findings for cardiovascular disease outcomes such as coronary heart disease, stroke, and mortality. Evidence for mechanisms through gut microbiota are also briefly reviewed. Recent findings Dietary fibre intake is associated with improved weight management, the extent of which may depend on the subtype of dietary fibre. Overall dietary fibre intake reduces blood glucose and HbA1c, however soluble fibres may be particularly effective in reducing HbA1c, fasting blood glucose and blood lipids. Individual meta-analyses and umbrella reviews of observational studies on dietary fibre, as well as major fibre types, observed inverse associations with incident coronary heart disease, stroke, and mortality due to cardiovascular disease. As different types of fibres exerted different health benefits, fibre diversity (i.e. combinations of fibres) should be further investigated. Summary Dietary fibres improve both short-term and long-term cardiometabolic disease risk factors and outcomes, and thus should be on every menu.

show abstract

The effect of Chinese herbal formulas combined with metformin on modulating the gut microbiota in the amelioration of type 2 diabetes mellitus: A systematic review and meta-analysis

Abstract: The effect of Chinese herbal formulas combined with metformin on modulating the gut microbiota in the amelioration of type 2 diabetes mellitus: A systematic review and meta-analysis.

Cited by 2 publications

References 97 publications

Advances in the mechanism of metformin with wide-ranging effects on regulation of the intestinal microbiota

Advances in the mechanism of metformin with wide-ranging effects on regulation of the intestinal microbiota

Role of dietary fibres in cardiometabolic diseases

Contact Info

Product

Resources

About