The effect of Chlamydia pneumoniae infection on serum lipid profile: A systematic review and meta-analysis

Mohammadzadeh, E.; Jalali-Jalalabadi, Hoda; Abdolahinia, Elaheh Dalir; Narimisa, Negar

doi:10.1016/j.genrep.2022.101585

Gene Reports

2022

DOI: 10.1016/j.genrep.2022.101585

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The effect of Chlamydia pneumoniae infection on serum lipid profile: A systematic review and meta-analysis

E. Mohammadzadeh

Hoda Jalali-Jalalabadi

Elaheh Dalir Abdolahinia³

et al.

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Cited by 2 publications

References 27 publications

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Design of a novel multiepitope vaccine against Chlamydia pneumoniae using the extracellular protein as a target

Guo,

Pan,

Sun

et al. 2023

Sci Rep

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Chlamydia pneumoniae (C. pneumoniae) infection in humans is universal and causes various respiratory infectious diseases, making a safe and effective preventive vaccine essential. In this study, a multi-epitope vaccine with CTLA-4 extracellular structure was constructed by an immunoinformatics approach. Since MOMP protein is the major extracellular protein in C. pneumoniae and has good immunogenicity and high conservation, we selected the MOMP protein of C. pneumoniae as the antigen target, predicted the T and B cell epitopes of the MOMP protein and then connected the CTLA-4 extracellular structure with the predicted dominant epitopes by various linkers to construct a multi-epitope vaccine. The biochemical characterization of the multi-epitope vaccine showed its immunogenicity and anti-allergic properties. The tertiary structure of this vaccine, along with molecular docking, molecular dynamics simulation, and principal component analysis, showed that the multi-epitope vaccine structure interacted with B7 (B7-1, B7-2) and toll-like receptors (TLR-2, TLR-4). Ultimately, the vaccine was cloned and effectively expressed in silico on an insect baculovirus expression vector (pFastBac1). These analyses showed that the designed vaccine could potentially target antigen-presenting cells and was immune to C. pneumoniae, which provided novel strategies for developing the vaccine.

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Design of a novel multiepitope vaccine against Chlamydia pneumoniae using the extracellular protein as a target

Guo,

Pan,

Sun

et al. 2023

Sci Rep

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The Detection of Chlamydia pneumoniae, Helicobacter pylori and Cytomegalovirus in Non-Atherosclerotic Arteries of Patients with Coronary Artery Disease

Šačić,

Tomić,

Milašin

et al. 2024

Pathogens

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Atherosclerotic coronary artery disease (ACAD) is a major cause of global morbidity and mortality, characterized as an inflammatory process due to damage to blood vessel walls by risk factors like aging, hyperlipidemia, hypertension, smoking, and diabetes. Infectious agents, including Chlamydia pneumoniae (Cpn), Cytomegalovirus (CMV), and Helicobacter pylori (HP), have been implicated in ACAD’s pathophysiology. A study with 56 subjects undergoing coronary artery bypass grafting (CABG) aimed to detect Cpn, CMV, and HP DNA in unaffected artery segments and explore associations with disease progression and inflammation markers. The study found infectious agents’ DNA in 21.4% of samples, HP in eight samples, and CMV and Cpn in four samples each. Significant correlations were observed between HP and overweight or obese subjects, as well as between the presence of infectious agents and inflammation marker values. An association between HP and renal function was also noted. The findings reaffirm previous discoveries of infectious agents in non-clinically affected arteries used as CABG grafts. Correlations identified between the presence of HP, CMV, and Cpn DNA in grafts and several biomarkers of inflammation and obesity emphasize the potential role of these infectious agents in ACAD pathogenesis.

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The effect of Chlamydia pneumoniae infection on serum lipid profile: A systematic review and meta-analysis

Cited by 2 publications

References 27 publications

Design of a novel multiepitope vaccine against Chlamydia pneumoniae using the extracellular protein as a target

Design of a novel multiepitope vaccine against Chlamydia pneumoniae using the extracellular protein as a target

The Detection of Chlamydia pneumoniae, Helicobacter pylori and Cytomegalovirus in Non-Atherosclerotic Arteries of Patients with Coronary Artery Disease

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