The effect of chlortetracycline on nutrient utilization by dairy calves

Bush, L.J.

doi:10.31274/rtd-180813-980

Cited by 2 publications

(3 citation statements)

References 23 publications

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“…Overall girth tended to be lower for L-supplemented heifers. Supplementation with CTC has been associated with increased skeletal development (Bush et al, 1959) and growth. Jacobson et al (1952) reported that though differences were small, trends were noted for CTC-supplemented calves to be taller at the withers and have greater chest depth and barrel circumference (P = 0.01) compared with calves that did not receive CTC.…”

Section: Discussionmentioning

confidence: 99%

Effects of lasalocid and intermittent feeding of chlortetracycline on the growth of prepubertal dairy heifers

Cabral

Erickson

Guindon

et al. 2013

Journal of Dairy Science

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Forty Holstein heifers entered the 12-wk study at approximately 12 wk of age. At enrollment, heifers were blocked by birth date and assigned to 1 of 4 treatments: (1) carrier (30 g; control); (2) lasalocid + carrier (1 mg/kg of body weight; L); (3) chlortetracycline + carrier (22 mg/kg of body weight; CTC); (4) L + CTC + carrier (CTCL). Heifers on CTC and CTCL were provided treatment Monday through Friday and carrier only on Saturday and Sunday. These heifers were provided their respective treatment during wk 1 to 4, 6, and 10; wk 5, 7 to 9, and 11 to 12 heifers were provided the nonmedicated carrier. Heifers were individually fed a total mixed ration with treatments top-dressed at 1200 h daily. Dry matter intake was monitored for each heifer and feed provided was adjusted according to individual intakes. Skeletal measurements were taken weekly and blood samples were obtained every Monday, Wednesday, and Friday. Blood samples were analyzed for thyroxine concentration via radial immunoassay. Heifers supplemented with L had lower average daily gain , overall body weight gain, and trends for lower daily body length gain and overall girth gain compared with CTC heifers, but similar to control and CTCL heifers. Heifers fed L had lower hip height gain and overall hip height gain compared with CTCL heifers, but similar to control and CTC heifers. Heifers fed L had lower overall withers height gain compared with control heifers, but similar to CTC and CTCL heifers. No treatment effect on thyroxine concentrations was observed. These data indicate that L did not increase growth. Results from this experiment indicate that supplementing heifers with L was not beneficial and no benefits to supplementing heifers with CTC or the combination of CTC and L were evident compared with control heifers. Heifers in this study experienced minimal health problems and were regarded to be under low stress levels. Supplementing CTC and L may be beneficial to growing heifers under conditions where disease exposure and stressors are greater.

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Section: Discussionmentioning

confidence: 99%

Effects of lasalocid and intermittent feeding of chlortetracycline on the growth of prepubertal dairy heifers

Cabral

Erickson

Guindon

et al. 2013

Journal of Dairy Science

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“…In the four studies in calves, three studies including a dietary chlortetracycline supplementation at 45 mg chlortetracycline/kg DM (Bush et al., 1959; Brown et al., 1960) and 80 mg chlortetracycline/kg DM (Murdock et al., 1961) showed growth‐promoting effects; no effects were observed at 70 mg chlortetracycline/kg DM (Hibbs and Conrad, 1958).…”

Section: Assessmentmentioning

confidence: 99%

“…In the study of Bush et al. (1959) the effect of chlortetracycline on growth and nutrient utilisation was studied in dairy calves. Sixteen 4‐day‐old male dairy calves (12 Holsteins, two Ayrshires and two Brown Swiss) were distributed in two dietary treatments, supplemented or not with 80 mg chlortetracycline (unspecified chemical form; Aurofac D) per calf and day (corresponding to 45 mg chlortetracycline/kg DM) for 16 weeks.…”

Section: Assessmentmentioning

confidence: 99%

Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 12: Tetracyclines: tetracycline, chlortetracycline, oxytetracycline, and doxycycline

Koutsoumanis¹,

Allende²,

Álvarez‐Ordóñez³

et al. 2021

EFS2

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The specific concentrations of tetracycline, chlortetracycline, oxytetracycline and doxycycline in nontarget feed for food-producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. The FARSC for these four tetracyclines was estimated. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. Levels in feed that showed to have an effect on growth promotion/increased yield were reported for tetracycline, chlortetracycline, oxytetracycline, whilst for doxycycline no suitable data for the assessment were available. Uncertainties and data gaps associated with the levels reported were addressed. It was recommended to perform further studies to supply more diverse and complete data related to the requirements for calculation of the FARSC for these antimicrobials.

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The effect of chlortetracycline on nutrient utilization by dairy calves

Cited by 2 publications

References 23 publications

Effects of lasalocid and intermittent feeding of chlortetracycline on the growth of prepubertal dairy heifers

Effects of lasalocid and intermittent feeding of chlortetracycline on the growth of prepubertal dairy heifers

Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 12: Tetracyclines: tetracycline, chlortetracycline, oxytetracycline, and doxycycline

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