The Effect of Cholestyramine on Bile Acid Kinetics in Healthy Controls

Andersen, Eva

doi:10.3109/00365527909181933

Cited by 25 publications

(5 citation statements)

References 12 publications

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“…1, which shows the fasting and postprandial concentrations of cholic acid, chenodeoxycholic acid and deoxycholic acid in a healthy subject before and during treatment with cholestyramine. In normolipidemic subjects the synthesis of cholic acid is increased to a greater extent (about threefold) than that of chenodeoxycholic acid (about twofold) [17]. As seen in Fig.…”

Section: Effects On Bile Acid Metabolismmentioning

confidence: 66%

Bile acid sequestrants: mechanisms of action on bile acid and cholesterol metabolism

Einarsson

Ericsson

Ewerth

et al. 1991

Eur J Clin Pharmacol

121

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Interruption of the enterohepatic circulation of bile acids by cholestyramine or colestipol influences the hepatic metabolism of cholesterol in many ways. The synthesis of bile acids is increased, as reflected by a several-fold increase in the activity of the cholesterol 7 alpha hydroxylase, the rate-determining enzyme in bile acid synthesis. The increased metabolism of cholesterol to bile acids causes an enhanced demand of cholesterol in the hepatocytes which respond with both new synthesis of cholesterol, as reflected in a several-fold increase of the HMG-CoA reductase activity, and increased expression of LDL receptors. As a consequence, the plasma level of LDL-cholesterol is lowered. The hepatic secretion rate of VLDL particles is increased. Cholestyramine therapy does not affect the output of biliary lipids or the cholesterol saturation of bile, indicating that treatment with bile acid sequestrants should not be associated with any increased risk of gallstone formation.

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Section: Effects On Bile Acid Metabolismmentioning

confidence: 66%

Bile acid sequestrants: mechanisms of action on bile acid and cholesterol metabolism

Einarsson

Ericsson

Ewerth

et al. 1991

Eur J Clin Pharmacol

121

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“…The increase of the CA group/CDCA group ratio in feces of the cholestyramine-fed rats is compatible with the result in germ-free rats (4). In man, synthesis of cholic acid also increased to a greater extent than that of chenodeoxycholic acid by cholestyramine treatment (23). Provided that bile acid metabolism of rats fed cholestyramine is in a steady state after eight days, the increase of the CA group/CDCA group ratio implies much more increase of cholic acid synthesis than chenodeoxycholic acid synthesis.…”

Section: Fecal Sterol and Bile Acid Determination Fecal Sterolsmentioning

confidence: 89%

Effect of cholestyramine on bile acid metabolism in conventional rats

Imai

Kawata

Inada

et al. 1987

Lipids

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Effects of cholestyramine on biliary secretion of cholesterol, phospholipids and bile acids and fecal excretion of sterols and bile acids were examined in Wistar male rats. Six rats were fed a basal diet, and the other six were fed a basal diet supplemented with 5% cholestyramine for eight days. Bile flow and biliary secretion of bile acids and phospholipids (per hour per rat) decreased with cholestyramine treatment, while biliary cholesterol secretion (per hour per rat) remained unchanged. In the biliary bile acid composition, a marked increase of chenodeoxycholic acid with a concomitant decrease of beta-muricholic acid was observed in cholestyramine-treated rats. Fecal excretion of total sterols and bile acids increased about three- and four-fold, respectively, after cholestyramine treatment. The increase of fecal bile acids derived from cholic acid was more predominant than that derived from chenodeoxycholic acid, resulting in an increase of the cholic acid group/chenodeoxycholic acid group ratio.

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“…Included in the study were also 20 middle-aged normoglycaemic, normolipidaemic, apparently healthy controls who were age-and sex-matched (mean age 55 ±2 years, II female, 9 male). Their basal data have been described [2,6,7]. All subjects and the controls participated in a long-term investigation on bile acid metabolism.…”

Section: Subjectsmentioning

confidence: 99%

Altered bile acid profiles in duodenal bile and urine in diabetic subjects

Andersen

Karlaganis

Sjövall

1988

Eur J Clin Investigation

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The bile acid composition in duodenal bile was analysed in 22 diet-treated and 11 insulin-treated middle-aged patients with diabetes mellitus and in 20 normoglycaemic controls. In 10 subjects with diabetes mellitus the bile acid profile in urine was also investigated. In the non-insulin-dependent diabetic patients the percentage of cholic acid was reduced and that of deoxycholic acid increased. As a highly significant finding there was a three-fold increase of the percentage of 12-ketolithocholic acid in duodenal bile in non-insulin-dependent diabetics, whereas the bile acid composition in insulin-dependent diabetics was similar to that in a control group. The percentage of 12-ketolithocholic acid in duodenal bile was positively correlated to the percentage in urine. In nine of the subjects studied, 12-ketolithocholic acid was the major individual bile acid in urine. It constituted 36.3 +/- 4.4% of the bile acids analysed and the excretion was 6.1 +/- 2.3 mumol 24 h-1. Together with 3 alpha, 12 beta-dihydroxy-5 beta-cholanoic acid it was predominantly present in the glycine conjugate fraction, whereas in bile its conjugation was similar to that of the other bile acids. The results may reflect an increased formation of secondary bile acids from cholic acid combined with a metabolic disturbance in non-insulin-dependent diabetics affecting the oxidoreduction of bile acids at C-12.

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The Effect of Cholestyramine on Bile Acid Kinetics in Healthy Controls

Cited by 25 publications

References 12 publications

Bile acid sequestrants: mechanisms of action on bile acid and cholesterol metabolism

Bile acid sequestrants: mechanisms of action on bile acid and cholesterol metabolism

Effect of cholestyramine on bile acid metabolism in conventional rats

Altered bile acid profiles in duodenal bile and urine in diabetic subjects

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