The effect of chondroitinase ABC and photobiomodulation therapy on neuropathic pain after spinal cord injury in adult male rats

Janzadeh, Atousa; Sarveazad, Arash; Hamblin, Michael R.; Teheripak, Gholamreza; Kookli, Keihan; Nasirinezhad, Farinaz

doi:10.1016/j.physbeh.2020.113141

Cited by 21 publications

(18 citation statements)

References 40 publications

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“…al. concluded the mentioned result, as well (70). Hence, future studies are suggested to contemplate on the efficacy of the combination therapies.…”

Section: Discussionmentioning

confidence: 59%

“…For example, Jevans et al In their study showed that coadministration of ChABC and neural stem cell had greater effect on motor recovery f than ChABC and cell therapy alone. Janzadeh et al have reported similar findings in simultaneous application of laser irradiation and ChABC administration (70). Therefore, in future studies, more attention should be paid to the effects of combinational therapy in SCI.…”

Section: Discussionmentioning

confidence: 65%

“…Therefore, combine application of ChABC and other therapeutic approach may increase its effectiveness. For example, there are studies that used combinational therapy of ChABC along with stem cells, lasers, and various scaffolds (69)(70)(71).…”

Section: Discussionmentioning

confidence: 99%

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Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis

Yousefifard

Janzadeh

Ali

et al. 2022

BCN

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Objective: The present systematic review and meta-analysis intends to conduct a comprehensive and complete search in electronic resources to investigate the role of administrating ChABC in improving complications following SCI. Methods: Medline, Embase, Scopus and Web of sciences were searched until the end of 2019. Two independent reviewers assessed the studies conducted on rats and mice and summarized the data. Using STATA 14.0 program, the findings were reported as pooled standardized mean differences (SMD) with 95% confidence intervals (CI). Results: 34 pre-clinical studies were included. ChABC administration generally improves locomotion recovery after SCI (SMD = 0.90; 95% CI: 0.61 to 1.20; p <0.001). Subgroup analysis showed that differences in SCI model (p = 0.732), severity of injury (p = 0.821), number of ChABC administration (p = 0.092), blinding status (p = 0.294), use of different locomotor score (p = 0.567) and follow up duration (p = 0.750) have no effect on the efficacy of ChABC treatment. Conclusion: The findings of the present study showed that prescribing ChABC has a moderate effect in the improvement of locomotion after SCI in mice and rats. However, this moderate effect introduces ChABC as an adjuvant therapy and not as a primary therapy.

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“…al. concluded the mentioned result, as well (70). Hence, future studies are suggested to contemplate on the efficacy of the combination therapies.…”

Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 65%

See 1 more Smart Citation

Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis

Yousefifard

Janzadeh

Ali

et al. 2022

BCN

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“…3 Department of Medical Library and Information Sciences, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran. 4 Department of Microbiology, Shahr-E-Qods Branch, Islamic Azad University, Tehran, Iran. 5 Medical University of Pécs Hungary, Pécs, Hungary.…”

Section: Authors' Contributionsmentioning

confidence: 99%

“…Although all people experience pain, many patients suffered chronic pain, which is so excruciating and affects the patient's quality of life [1][2][3]. Various chemicals [4] and natural substances [5,6] and new treatment methods such as photobiomodulation therapy [7,8] have shown analgesic effects but their administration is not approved.…”

Section: Introductionmentioning

confidence: 99%

The effect of gabapentin and pregabalin administration on memory in clinical and preclinical studies: a meta-analysis and systematic review

et al. 2023

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Background Today, gabapentinoids such as Gabapentin (GBP) and pregabalin (PGB) are widely used as painkillers. This may alter the function of the nervous system; hence their results may include a difference in memory and processes that end in memory formation. This study aims to conclude whether gabapentinoids can alter memory or not by reviewing and analyzing clinical and preclinical studies. Material and methods A comprehensive search was carried out in databases including PUBMED, EMBASE, SCOPUS, and Web of Science. In the included studies, memory was measured as an outcome variable in clinical or preclinical studies. Result A total of 21 articles (4 clinical, 17 preclinical) were included in the meta-analysis by STATA Software. The results showed that memory changes under the influence of GBP. Both the administrated dosage and the time of administration are important in the final results and latency time of retention. GBP administration in healthy animals increased latency time, whereas if the administration of GBP took place exactly before training, the latency time increased slightly. Short-term administration of PGB in healthy volunteers is accompanied by transient side effects on the CNS. However, the number and homogeneity of the studies were not such that a meta-analysis could be performed on them. Conclusion Clinical and preclinical studies showed that PGB administration did not confirm its improving memory effect. GBP administration in healthy animals increased latency time and improved memory. Although it depended on the time of administration.

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Time-dependent photobiomodulation management of neuropathic pain induced by spinal cord injury in male rats

et al. 2023

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The effect of chondroitinase ABC and photobiomodulation therapy on neuropathic pain after spinal cord injury in adult male rats

Cited by 21 publications

References 40 publications

Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis

Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis

The effect of gabapentin and pregabalin administration on memory in clinical and preclinical studies: a meta-analysis and systematic review

Time-dependent photobiomodulation management of neuropathic pain induced by spinal cord injury in male rats

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