The effect of chronic calcium treatment on thyroid C cells in ovariectomized rats

Filipović, Branka; Šošić‐Jurjević, Branka; Manojlović‐Stojanoski, Milica; Nestorović, Nataša; Milošević, Verica; Sekulić, Milka

doi:10.1016/j.lfs.2004.09.046

Cited by 4 publications

(2 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, estrogen treatment was found to have a stimulatory effect on CT secretory activity of C cells in Ovx rats (Grauer et al, 1993;Filipović et al, 2003), Orx rats (Filipović et al, 2010a) and women (Isaia et al, 1992). In addition to estrogen, chronic calcium administration after Ovx increased the release of CT from C cells without affecting CT synthesis, suggesting that estrogen plays an important role in CT synthesis (Filipović et al, 2005). On the other hand, CT administration, which may be useful for treatment of osteoporosis, negatively affected rat thyroid C cells by a negative feedback mechanism (Sekulić et al, 2005).…”

Section: Indirect Effects Of Phytoestrogens On Bone -The Role Of Calcmentioning

confidence: 98%

The Phytoestrogens, Calcitonin and Thyroid Hormones: Effects on Bone Tissue

Filipović¹,

Šošić‐Jurjević²

2012

Osteoporosis

View full text Add to dashboard Cite

Section: Indirect Effects Of Phytoestrogens On Bone -The Role Of Calcmentioning

confidence: 98%

The Phytoestrogens, Calcitonin and Thyroid Hormones: Effects on Bone Tissue

Filipović¹,

Šošić‐Jurjević²

2012

Osteoporosis

View full text Add to dashboard Cite

“…Histomorphometry or stereology of C-cell numbers can be used to improve the sensitivity of discovering diffuse C-cell hyperplasia in rats, mice, dogs, or nonhuman primates (Filipovic et al 2005). C-cells represent a greater proportion of the thyroid gland in rats (4–10%) compared to monkeys and humans (<1%) and C-cell numbers increase in rats as they age (Bjerre Knudsen et al 2010; Kameda 1983; Martin-Lacave et al 1992).…”

Section: Function Of Glp-1 In C-cellsmentioning

confidence: 99%

On-target Effects of GLP-1 Receptor Agonists on Thyroid C-cells in Rats and Mice

Rosol

2013

Toxicol Pathol

View full text Add to dashboard Cite

Glucagon-like peptide-1 is an incretin hormone from the gastrointestinal tract, which enhances insulin secretion, slows gastric emptying, and reduces food intake. GLP-1 receptor agonists are being developed for Type 2 diabetes mellitus. GLP-1 is rapidly degraded by serum dipeptidyl peptidase IV, so analogues with a prolonged serum half-life are used clinically. Exenatide was the first GLP-1 agonist approved and is a synthetic version of exendin-4 derived from the Gila monster. Liraglutide was approved for clinical use in 2010. GLP-1 receptor agonists have been shown to increase calcitonin secretion and stimulate C-cell hyperplasia and neoplasia in rats and mice of both sexes. Rat C-cells are more sensitive to the effects of GLP-1 agonists than mice. The effects of GLP-1 agonists on C-cell proliferation or neoplasia have not been documented in nonhuman primates or humans. The proliferative C-cell effects may be rodent-specific. GLP-1 receptors have been demonstrated on normal rodent C-cells, but are either not present or occur in low numbers on C-cells of nonhuman primates and humans. Hyperplasia and neoplasia of C-cells in rodents treated with GLP-1 agonists represent a unique example of an on-target species-specific effect that may not have relevance to humans.

show abstract

Effect of Captopril and Melatonin on Fibrotic Rebuilding of the Aorta in 24 Hour Light-Induced Hypertension

Repová-Bednárová¹,

Aziriova²,

Hrenak³

et al. 2013

Physiol Res

View full text Add to dashboard Cite

Chronic continuous light exposure leads to melatonin deficiency along with complex neurohumoral activation resulting in hypertension development in rats. The aim of this study was to show, whether continuous light induces fibrotic rebuilding of the aorta and whether the treatment with melatonin or angiotensin converting enzyme inhibitor captopril can prevent these potential alterations. In a six-week experiment, 3-month-old Wistar rats were divided into 4 groups (ten per group): controls, rats exposed to continuous light, exposed to continuous light plus treated with captopril (100 mg/kg/24 h) and exposed to continuous light plus treated with melatonin (10 mg/kg/24 h). Systolic blood pressure (SBP) and collagen type I and III in the media of thoracic aorta were measured. Continuous light induced hypertension and fibrotic rebuilding of the aorta in terms of enhancement of collagen I and III concentration in the aortic media. Both captopril and melatonin prevented SBP rise and reduced collagen III concentration in the aorta. However, only melatonin reduced collagen I and the sum of collagen I and III in the aortic tissue. We conclude that in continuous light-induced hypertension, administration of melatonin, along with SBP reduction, decreases collagen I and III concentration in the aorta. It is suggested that antifibrotic effect of melatonin may reduce the stiffness of the aorta and small arteries and beneficially influence the nature of the pulse wave and peripheral vascular resistance.

show abstract

The effect of chronic calcium treatment on thyroid C cells in ovariectomized rats

Cited by 4 publications

References 26 publications

The Phytoestrogens, Calcitonin and Thyroid Hormones: Effects on Bone Tissue

The Phytoestrogens, Calcitonin and Thyroid Hormones: Effects on Bone Tissue

On-target Effects of GLP-1 Receptor Agonists on Thyroid C-cells in Rats and Mice

Effect of Captopril and Melatonin on Fibrotic Rebuilding of the Aorta in 24 Hour Light-Induced Hypertension

Contact Info

Product

Resources

About