The Effect of Chronic Lung Disease on the Course of Ageing in the Male Rat

Everitt, Arthur V.; Cavanagh, Lorraine M.

doi:10.1159/000211203

Cited by 2 publications

(6 citation statements)

References 12 publications

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“…In the previous paper [Everitt and Cavanagh, 1963) it was reported that rats with diseased lungs at autopsy (group Dl in the present paper) had significantly higher blood haemoglobin contents in old age (tA-D = 2.44, P < 0.05) than those with healthy lungs (group A1 in the present paper).…”

Section: Resultssupporting

confidence: 60%

“…It was shown in the previous paper (Everitt and Cavanagh, 1963) that rats with diseased lungs (group D and table I in the present paper) were heavier at 300, 400, 500, and 600 days and lighter at 700 days than rats with healthy lungs (group A). In the present paper group D is subdivided into group B (which has the same longevity as group A) and group C which contains the shorterlived rats that demonstrate the effect of dying.…”

Section: Resultssupporting

confidence: 58%

“…It was reported in the previous paper (Everitt and Cavanagh, 1963) that the weight loss between 400 and 700 days (W400-W 700) increased significantly in proportion to the severity of lung disease. Re-examination of these data (table III) indicates that this effect is really due to the process of dying.…”

Section: Resultsmentioning

confidence: 85%

“…In the previous paper (Everitt and Cavanagh, 1963) the ageing process was compared in rats with diseased lungs and in those with healthy lungs. The comparison was made between the long-lived halves of these two rat populations, but did not take into account differences in longevity.…”

Section: Resultsmentioning

confidence: 99%

“…The process of dying has been studied over the last 100 days in the life of the rat and quite large changes have been observed in a number of physio logical variables (Everitt, 1957 a and b; Everitt, 1958 a, b and c;Everitt and Webb, 1958). In one paper (Everitt, 1958a) it was suggest ed that data obtained from rats which die in the 100 days sub sequent to the measurement of a physiological variable should not be included in studies of the ageing process.It was recently reported (Everitt and Cavanagh, 1963) that lung disease has significant effects on body weight and the blood picture in the ageing rat. The purpose of the present paper is to determine whether these changes are due entirely to lung disease or whether they are, in part, due to the process of dying.…”

mentioning

confidence: 99%

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The Effect of Lung Disease and the Process of Dying on the Body Weight and Blood Picture of the Ageing Male Rat

Everitt¹,

Cavanagh²

1963

Gerontology

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Section: Resultssupporting

confidence: 60%

Section: Resultssupporting

confidence: 58%

Section: Resultsmentioning

confidence: 85%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

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The Effect of Lung Disease and the Process of Dying on the Body Weight and Blood Picture of the Ageing Male Rat

Everitt¹,

Cavanagh²

1963

Gerontology

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Caloric restriction versus drug therapy to delay the onset of aging diseases and extend life

Everitt

Roth

Couteur

et al. 2005

AGE

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There are two firmly established methods of prolonging life. Calorie restriction (CR) using nutrient-rich diets to prolong life in lower animals, and life saving medications in humans to delay the development of the major diseases of middle and old age. These two approaches have different mechanisms of action. In rats, CR at 40% below ad libitum intake begun soon after weaning and continued until death, reduces body weight by about 40% and increases lifespan. There have been no lifelong CR studies performed on humans. However, in healthy adult human subjects about 20% CR over a period of 2-15 years, lowers body weight by about 20% and decreases body mass index (BMI) to about 19. This CR treatment in humans reduces blood pressure and blood cholesterol to a similar extent as the specific drugs used to delay the onset of vascular disease and so extend human life. These same drugs may act by mechanisms that overlap with some of the mechanisms of CR in retarding these pathologies and thus may have similar antiaging and life prolonging actions. Such drugs may be regarded as CR mimetics which inhibit the development of certain life shortening diseases, without the need to lower calorie intake. In developed countries, better medical care, drug therapy, vaccinations, and other public health measures have extended human life by about 30 years during the 20th century without recourse to CR, which is so effective in the rat. The percentage gain in human life expectancy during the 20th century is twice that achieved by CR in rat survival. However, rat longevity studies now use specific pathogen-free animals and start CR after weaning or later, thereby excluding deaths from infectious diseases and those associated with birth and early life. There is a need to develop CR mimetics which can delay the development of life-threatening diseases in humans. In the 21st century due to the human epidemic of overeating with a sedentary lifestyle, it may necessary to utilize CR to counter the aging effects of overweight. Since the greatest life-extending effects of CR in the rodent occur when started early in life, long-term antiaging therapy in humans should be initiated soon after maturity, when physiological systems have developed optimally.

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The Effect of Chronic Lung Disease on the Course of Ageing in the Male Rat

Cited by 2 publications

References 12 publications

The Effect of Lung Disease and the Process of Dying on the Body Weight and Blood Picture of the Ageing Male Rat

The Effect of Lung Disease and the Process of Dying on the Body Weight and Blood Picture of the Ageing Male Rat

Caloric restriction versus drug therapy to delay the onset of aging diseases and extend life

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