The Effect of Chronic Sodium Loading and Sodium Restriction on Plasma Prostaglandin A, E and F Concentrations in Normal Humans

Rm, Zusman; Spector, David A.; Bv, Caldwell; Speroff, Leon; Schneider, George; Pj, Mulbow

doi:10.1172/jci107274

Cited by 81 publications

(16 citation statements)

References 22 publications

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“…Terragno et al [20] found an increased PG biosynthesis in kidneys chronically exposed to an excess of Na+; and other authors have reported a reduction of endogenous PG lev el after salt-loading [22,25,26]. Consider ing all these data, our results suggest that after salt-loading, there was no close corre lation between RIC granularity and PG lev el or PG biosynthesis in the kidneys.…”

Section: Discussionsupporting

confidence: 46%

Influence of Dietary Linoleic Acid Content on the Cytoplasmic Granularity of Renomedullary Interstitial Cells

Somova¹,

Jurukova²,

Hoffmann³

et al. 1979

Kidney Blood Press Res

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A study of the influence of different diets (rich and deficient in polyunsaturated fatty acids) and of indomethacin on the mean count of renomedullary interstitial cell (RIC) lipid granules was undertaken. A correlation between dietary linoleic acid (LA) content (the main precursor of endogenous prostaglandin biosynthesis) and the number of granules in RIC was demonstrated: in comparison to the salt-loaded rats fed standard pellet diet, the number of RIC lipid granules in salt-loaded rats fed LA in excess increased, while in salt-loaded rats on LA-deficient diet the RIC granularity tended to decrease. Indomethacin treatment caused an increase in RIC granularity in salt-loaded rats fed a standard pellet diet and in those fed LA in excess, but had no effect in salt-loaded rats fed LA-deficient diet.

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Section: Discussionsupporting

confidence: 46%

Influence of Dietary Linoleic Acid Content on the Cytoplasmic Granularity of Renomedullary Interstitial Cells

Somova¹,

Jurukova²,

Hoffmann³

et al. 1979

Kidney Blood Press Res

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“…The plasma concentration of endogenous PGE1 at steady state is approximately 0.25 ng/mL. 35 Analysis of fundus photographs showed that PGE1 substantially dilated the retinal vessels. Typically 10 to 20 minutes after the start of PGE1 administration, some patients reported brightening of their vision.…”

Section: Discussionmentioning

confidence: 99%

Systemic Prostaglandin E1 to Treat Acute Central Retinal Artery Occlusion

Takai¹,

Tanito²,

Matsuoka³

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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Citation: Takai Y, Tanito M, Matsuoka Y, Hara K, Ohira A. Systemic prostaglandin E1 to treat acute central retinal artery occlusion. Invest Ophthalmol Vis Sci. 2013;54:3065-3071. DOI:10.1167/iovs.12-11445 PURPOSE. To report the efficacy of systemic prostaglandin E1 (PGE1) monotherapy for treating acute central retinal artery occlusion (CRAO).METHODS. The best-corrected visual acuity (BCVA) and side effects were evaluated retrospectively in 10 consecutive eyes (nine patients; mean age, 61.3 years) with acute CRAO treated with PGE1 monotherapy. The protocol included intravenous injection of 40 lg PGE1 twice daily (80 lg per day) for 5 days then oral PGE1 three times daily (30 lg per day) for at least 1 month. In four eyes, the retinal vessel diameters were assessed on serial fundus photographs. RESULTS.The mean time to treatment was 7.1 hours (range, 1-18 hours). The mean 6 SD logarithm of the minimum angle of resolution (logMAR) BCVAs at baseline and 1 month after initiation of therapy were 2.67 6 0.54 (range, 3.00-1.70) and 0.52 6 0.62 (range, 2.00 to À0.18), respectively (P ¼ 0.005); the BCVA improved by 1.0 or more logMAR unit at 1 month in all eyes. The BCVA improvement was correlated negatively with the time to treatment (q ¼ À0.655, P ¼ 0.0492), but was not correlated with age (q ¼ À0.473, P ¼ 0.156) and did not differ between sexes (P ¼ 0.0871). Compared with baseline, the mean changes in the vessel diameters in four cases were 151.1% (range, 115.1%-188.0%) in the arteries and 191.0% (range, 127.2%-246.4%) in the veins 1 day after initiation of therapy. Angialgia during injection was the only side effect.CONCLUSIONS. Systemic administration of PGE1 for acute CRAO rapidly restores retinal blood flow by its vasodilatory effects, improves VA, is well tolerated with few side effects, and requires no special training.

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“…In human lung, for example, the PGE 2 concentration is about 25 ng/gram tissue, or ‫ف‬ 70 nM; in human semen this value is ‫ف‬ 25 g/ml, or ‫ف‬ 70 M (53). On the other hand, plasma PGE and PGF concentrations in humans are ‫ف‬ 0.25 ng/ml, or 0.7 nM (54). Assuming that hPGT is the mechanism for reuptake of PGs after their release, this plasma concentration would represent the residual from such a process.…”

Section: Discussionmentioning

confidence: 99%

Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT).

Lu¹,

Kanai²,

Bao³

et al. 1996

J. Clin. Invest.

211

138

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We recently identified a cDNA in the rat that encodes a broadly expressed PG transporter (PGT). Because PGs play diverse and important roles in human health and disease, we cloned human PGT (hPGT) from an adult human kidney cDNA library. A consensus sequence (4.0 kb) derived from several clones, plus 3 Ј polymerase chain reaction amplification, exhibited 74% nucleic acid identity and 82% amino acid identity compared to rat PGT. When transiently expressed in HeLa cells, a full-length clone catalyzed the transport of PGE 1 , PGE 2 , PGD 2 , PGF 2 ␣ and, to a lesser degree TXB 2 . Northern blotting revealed mRNA transcripts of many different sizes in adult human heart, placenta, brain, lung, liver, skeletal muscle, pancreas, kidney, spleen, prostate, ovary, small intestine, and colon. hPGT mRNAs are also strongly expressed in human fetal brain, lung, liver, and kidney. The broad tissue distribution and substrate profile of hPGT suggest a role in the transport and/or metabolic clearance of PGs in diverse human tissues. ( J. Clin. Invest.

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The Effect of Chronic Sodium Loading and Sodium Restriction on Plasma Prostaglandin A, E and F Concentrations in Normal Humans

Cited by 81 publications

References 22 publications

Influence of Dietary Linoleic Acid Content on the Cytoplasmic Granularity of Renomedullary Interstitial Cells

Influence of Dietary Linoleic Acid Content on the Cytoplasmic Granularity of Renomedullary Interstitial Cells

Systemic Prostaglandin E1 to Treat Acute Central Retinal Artery Occlusion

Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT).

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