The effect of chronic vulvar dystrophy on urinary continence in patients at climacterium

Brătilă, Elvira; Cîrstoiu, Monica Mihaela; Mehedințu, Claudia; Berceanu, Costin; Bohîlțea, Roxana Elena; Toader, Oana; Comandașu, Diana-Elena

doi:10.1016/j.maturitas.2017.03.171

Cited by 2 publications

(2 citation statements)

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“…One study was a case series of 22 patients with LS. UI was present in 90% of cases; however, the method of diagnosis of UI was unclear 17 . A further cross‐sectional study compared rates of UI in several vulval diseases including LS to control patients attending for annual gynaecology examination.…”

Section: Resultsmentioning

confidence: 99%

“…UI was present in 90% of cases; however, the method of diagnosis of UI was unclear. 17 A further cross-sectional study compared rates of UI in several vulval diseases including LS to control patients attending for annual gynaecology examination. The validated Urinary Distress Inventory short form score (UDI-6) was used to diagnose UI.…”

Section: Descriptive Analysismentioning

confidence: 99%

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Is urinary incontinence associated with lichen sclerosus in females? A systematic review and meta‐analysis

Kirby

Gran

Kreuser‐Genis

et al. 2021

Skin Health and Disease

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Background Lichen sclerosus (LS) is a scarring chronic inflammatory disease with a predilection for genital skin in both sexes. The aetiology of LS is controversial, but evidence increasingly suggests that the occluded exposure of susceptible epithelium to urine is involved in the pathogenesis of genital LS in males. This theory has not yet been robustly investigated in females. Objectives This review and meta‐analysis examined whether there is an association between urinary incontinence (UI) and genital lichen LS in females. Methods We performed a comprehensive search of MEDLINE, Embase and CINAHL to identify observational studies assessing the prevalence of UI in females with LS. DerSimonian and Laird random‐effects models were used to estimate the overall pooled prevalence and risk ratio compared to controls. Heterogeneity was assessed. Results In total, eight studies met the inclusion criteria and five studies were included in a meta‐analysis. Three studies were graded as moderate quality and five were poor. The pooled prevalence for UI in LS was 0.35 (95% confidence interval [CI] 0.13–0.58, I2 = 98.4%). The risk ratio of UI in LS was 0.97 (95% CI 0.53–1.75, I2 = 87.5%). Conclusion There appears to be no difference between patients with LS and those without LS in terms of UI. Studies are limited by clinical and methodological quality and heterogeneity is high. Well‐designed prospective studies are needed.

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Section: Resultsmentioning

confidence: 99%

Section: Descriptive Analysismentioning

confidence: 99%

Is urinary incontinence associated with lichen sclerosus in females? A systematic review and meta‐analysis

Kirby

Gran

Kreuser‐Genis

et al. 2021

Skin Health and Disease

View full text Add to dashboard Cite

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EuroGuiderm guideline on lichen sclerosus—introduction into lichen sclerosus

Kirtschig,

Kinberger,

Kreuter

et al. 2024

Acad Dermatol Venereol

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IntroductionLichen sclerosus (LS) is an inflammatory skin disease affecting all ages. LS typically involves the anogenital site where it causes itching and soreness. It may lead to sexual and urinary dysfunction in females and males; however, it may be asymptomatic. First signs of LS are redness and oedema, typically followed by whitening of the genital skin; sometimes fissuring, scarring, shrinkage and fusion of structures may follow in its course. LS is associated with an increased risk of genital cancer. LS has a huge impact on the quality of life of affected patients, and it is important to raise more awareness of this not uncommon disease in order to diagnose and treat it early.ObjectivesThe guideline intends to provide guidance on the diagnostic of LS, highlight important aspects in the care of LS patients (part 1), generate recommendations and treatment algorithms (part 2) on topical, interventional and surgical therapy, based on the latest evidence, provide guidance in the management of LS patients during pregnancy, provide guidance for the follow‐up of patients with LS and inform about new developments and potential research aspects.Materials and MethodsThe guideline was developed in accordance with the EuroGuiDerm Methods Manual v1.3 https://www.edf.one/de/home/Guidelines/EDF‐EuroGuiDerm.html. The wording of the recommendations was standardized (as suggested by the GRADE Working Group). The guideline development group is comprised of 34 experts from 16 countries, including 5 patient representatives.ResultsUltrapotent or potent topical corticosteroids in females and males, adults and children remain gold standard of care for genital LS; co‐treatment with emollients is recommended. If standard treatment fails in males, a surgical intervention is recommended, complete circumcision may cure LS in males. UV light treatment is recommended for extragenital LS; however, there is limited scientific evidence. Topical calcineurin inhibitors are second line treatment. Laser treatment, using various wave lengths, is under investigation, and it can currently not be recommended for the treatment of LS. Treatment with biologics is only reported in single cases.ConclusionsLS has to be diagnosed and treated as early as possible in order to minimize sequelae like scarring and cancer development. Topical potent and ultrapotent corticosteroids are the gold standard of care; genital LS is often a lifelong disease and needs to be treated long‐term.

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The effect of chronic vulvar dystrophy on urinary continence in patients at climacterium

Cited by 2 publications

References 0 publications

Is urinary incontinence associated with lichen sclerosus in females? A systematic review and meta‐analysis

Is urinary incontinence associated with lichen sclerosus in females? A systematic review and meta‐analysis

EuroGuiderm guideline on lichen sclerosus—introduction into lichen sclerosus

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