The Effect of Chronically Increased Intra-Abdominal Pressure on Rectus Abdominis Muscle Histology an Experimental Study on Rabbits

Can Chronic Intra-Abdominal Hypertension Cause Oxidative Stress to the Abdominal Wall Muscles? An Experimental Study

“…These studies showed that changes in the muscle fiber profile can result from metabolic abnormalities. In a previous study [9], using the same animal model, we proved that chronic intra-abdominal hypertension can also cause remodeling in the rectus abdominis muscle. In the present study, we test the hypothesis that chronic intraabdominal hypertension can cause oxidative stress to the rectus abdominis muscle and trigger compensatory mechanisms.…”

“…The system used to increase the intra-abdominal pressure consisted of three parts [8,9]. The rubber bag with a capacity of 300 mL, the connecting tube, and the valve for external control of intra-abdominal pressure, similar to the valve used in adjustable gastric bands (Fig.…”

Active behavior of abdominal wall muscles: Experimental results and numerical model formulation

“…In human abdominal muscles, there is a slow fiber (type I) predominance (50-60%) (Iscoe, 1998) and it has been described in the same way for the rabbit abdominal muscles: 60% fibers type I and 30% fibers type IIA in RA muscle (Kotidis et al, 2011). Slow fibers are characterized by low force values, slow reaction to the electrical stimulus, small size and fatigue resistance.…”

“…The passive mechanical properties of the abdominal muscles have been investigated by several authors in different species: rat (Hwang et al, 2005;Brown et al, 2012;Brown, 2012), rabbit Simón-Allué et al, 2015), pig (Van Loocke et al, 2008;Lyons et al, 2014) and human (Förstemann et al, 2011). Moreover, the whole abdominal wall response to an increase of the intra-abdominal pressure has also been studied (Kotidis et al, 2011;Park et al, 2012;Rohlmann et al, 2006). Regarding the anisotropy of the tissue, this effect has been considered by Hwang et al (2005) in a work where samples of tissue were loaded passively in two directions.…”

The Effects of Chronically Increased Intra-abdominal Pressure on the Rabbit Diaphragm

“…Harvey Sugerman was the first to suggest that chronically increased IAP may be in the center of many obesity complications, while Varela et al and Zacchi et al correlated directly the chronically elevated IAP due to obesity to comorbidities and to the chronic inflammatory nature of the disease and vice versa [11,16]. Chronically elevated IAP affects in general the cardiovascular, respiratory, renal, and musculoskeletal systems [17][18][19][20]. More specifically, elevated IAP increases pleural pressure, cardiac filling pressures, femoral venous pressure, renal venous pressure, systemic blood pressure, and vascular resistance, renin and aldosterone levels, and intracranial pressure.…”