The effect of cigarette smoke on the respiratory system of the rabbit. A preliminary report

Holland, Robert H.; Wilson, Russell H.; Morris, Deloia; McCall, Mary Sue; Lanz, Henry

doi:10.1002/1097-0142(195807/08)11:4<709::aid-cncr2820110406>3.0.co;2-1

Cited by 23 publications

(5 citation statements)

References 5 publications

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“…Previous attempts to clarify the pathogenesis of chronic bronchitis and emphysema with animal models have incluided exposture to nitrogen dioxide (22), stulphur dioxide (23)(24)(25)(26), isoprenaline (27,28), cigarette smoke (29)(30)(31)(32)(33)(34)(35)(36), and enzymes (9, 10, 37-39). These agents cause lung damage with varying simiiilarity to hutmiian disease.…”

Section: Discussionmentioning

confidence: 99%

Irreversible bronchial goblet cell metaplasia in hamsters with elastase-induced panacinar emphysema.

Christensen¹,

Korthy²,

Snider³

et al. 1977

J. Clin. Invest.

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A B S T R A C T A single intratraclheal instillation of pancreatic elastase in hamsters indtuces a lesion resembling human panacinar emphysema. This paper reports the occurrence of irreversible goblet cell metaplasia in the bronchiial epithelitum of hamsters similarly exposed to elastase. The goblet cell change was dose related; a dose of 0.1 mg/100 g body wt or less at 16 days, prodtuced slight or moderate goblet cell metaplasia in fewer than half the animals, whereas 84% of animals treated with a dose between 0.2 and 0.5 mg/100 g body wt developed goblet cell metaplastic lesions, more than half of which were considered to be severe. The percentage of goblet cells in the epithelium of elastase-treated hamsters (32.5) was significantly higher (P < 0.005) than that of tunexposed (12.2) and saline-exposed controls (18.7). All hamsters examined 6 and 12 mo after elastase treatment showed the lesion. The pathogenesis of the changes is unclear btut the possibility is raised that the bronchial changes may be dtue to disturbance of an endogenous protease-antiprotease system. The findings suggest the hypothesis that, uinder appropriate circu-mstances, a single puilmonary insult in man could lead to a permanent luing injtury demonstrating the anatomic lesions of both chronic bronchitis and panacinar emphysema.

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Section: Discussionmentioning

confidence: 99%

Irreversible bronchial goblet cell metaplasia in hamsters with elastase-induced panacinar emphysema.

Christensen¹,

Korthy²,

Snider³

et al. 1977

J. Clin. Invest.

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“…Mainstream Smoke Exposure. Purebred New Zealand Red rabbits, specially selected for their acceptance of mainstream smoke (5), were purchased from two broods over a 1-year period from Mayfair Rabbitry, Taunton, Mass.…”

Section: Methodsmentioning

confidence: 99%

“…Studies with arsenic-74-supplemented mainstream tobacco smoke showed that rabbits retained 0.01% of the volatilized arsenic, and the distribution of the arsenic in the respiratory tract 2 hours after smoking was discussed (5). Following withdrawal from tobacco smoke containing As74, the radioactivity decreased rapidly during the first 2 days and then tapered off slowly.…”

Section: Fate Of Inhaled C14-tde In Rabbitsmentioning

confidence: 99%

Metabolism of Insecticide Residues, Fate of Inhaled C¹⁴TDE in Rabbits

Bowery¹,

Gatterdam²,

Guthrie³

et al. 1965

J. Agric. Food Chem.

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“…This chamber (as well as the control unit with fresh air) had a volume of 56 L housing the test animals (strain A albino mice with an appreciable rate of spontaneous tumor development) during the whole experiment. Smoking of the (plain) cigarettes was done with one continuous puff without leaving To study the effects of cigarette smoke on the respiratory system of rabbits, HOLLAND et al (303) housed and treated animals individually in compartments, through which continuous suction was maintained. For supplying smoke, a single cigarette was inserted into a sealable port; after lighting an electrically controlled selenoid valve allowed smoke (30-60 mL) to enter the compartment during 2 sec every min.…”

Section: Smoke Generation and Exposure In Inhalation Studies With Rodmentioning

confidence: 99%

Cigarette Mainstream Smoke: The Evolution of Methods and Devices for Generation, Exposure and Collection

Klus¹,

Boenke-Nimphius²,

Müller

2016

Beiträge Zur Tabakforschung International/Contributions to Tobacco Research

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SUMMARYThe objective of this review is to support tobacco scientists when evaluating information published on smoking machines, and on cigarette mainstream smoke (in vivo and in vitro) exposure systems and collection devices. The intriguing development of smoking machines (mainly for cigarettes) is followed for more than 170 years -from the first simple set-ups in the 1840s to the sophisticated and fully automated analytical smoking machines available today. Systems for the large-scale production of smoke (condensate) for preparative work are equally considered. The standardization of machine smoking methods and test pieces has solved several technical problems and produced sensible rules but, at the same time, given rise to new controversies like the compatibility of artificial and human smoking, and the implementation of more intense machine smoking regimes. Adequate space is allotted for the discussion of configurations for in vivo smoke exposure of rodent and non-rodent species and the machines generating the required smoke (condensate). Covered as well is the field of in vitro toxicity testing, including the increasingly informative new techniques of air-liquid interface exposure, which are becoming more and more refined with the use of organotypic cultures and genetic analyses. The review is completed by the examination of the considerable variety of mainstream smoke collection devices (filters and traps) developed over time -some for very specific purposes -and refers to the perpetual problem of artifact formation by aging.

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The effect of cigarette smoke on the respiratory system of the rabbit. A preliminary report

Cited by 23 publications

References 5 publications

Irreversible bronchial goblet cell metaplasia in hamsters with elastase-induced panacinar emphysema.

Irreversible bronchial goblet cell metaplasia in hamsters with elastase-induced panacinar emphysema.

Metabolism of Insecticide Residues, Fate of Inhaled C¹⁴TDE in Rabbits

Cigarette Mainstream Smoke: The Evolution of Methods and Devices for Generation, Exposure and Collection

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The effect of cigarette smoke on the respiratory system of the rabbit. A preliminary report

Cited by 23 publications

References 5 publications

Irreversible bronchial goblet cell metaplasia in hamsters with elastase-induced panacinar emphysema.

Irreversible bronchial goblet cell metaplasia in hamsters with elastase-induced panacinar emphysema.

Metabolism of Insecticide Residues, Fate of Inhaled C14TDE in Rabbits

Cigarette Mainstream Smoke: The Evolution of Methods and Devices for Generation, Exposure and Collection

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Metabolism of Insecticide Residues, Fate of Inhaled C¹⁴TDE in Rabbits