The effect of cimetidine on antipyrine metabolism in calves

Janus, K; Suszycka, J

doi:10.1046/j.1365-2885.1997.00040.x

Vet Pharm & Therapeutics

1997

DOI: 10.1046/j.1365-2885.1997.00040.x

|View full text |Cite

The effect of cimetidine on antipyrine metabolism in calves

K Janus

J Suszycka

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1999

2001

Publication Types

Select...

Article2

Relationship

Self Cite1

Independent1

Authors

Journals

Cited by 2 publications

(1 citation statement)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antipyrine is one of the most extensively used model compounds for the characterisation of the oxidative drug metabolizing systems (cytochrome P-450 linked monooxygenase) in vivo (Loft, 1990;Witkamp et al, 1990;Offiah et al, 1992;Konig & Cantilena, 1994;Monshouwer et al, 1994;Ferre et al, 1996;Janus & Suszycka, 1997).…”

mentioning

confidence: 99%

The effect of sex on antipyrine metabolism in cattle at different ages

Janus

Antoszek

1999

Vet Pharm & Therapeutics

Self Cite

View full text Add to dashboard Cite

The aim of this study was to determine the effect of sex on the metabolism of antipyrine by measuring the antipyrine plasma clearance as well as excretion of three major metabolites in urine in cattle of different ages. The experiment was carried out on 10 female and 10 male cattle of Black and White breed. The antipyrine test was carried out at 1, 2, 4, 6, 8, 12 and 18 months of age for each animal (single dose of 10 mg/kg antipyrine were given intravenously). The concentrations of antipyrine, 4-hydroxyantipyrine (4-OHA), 3-hydroxymethylantipyrine (HMA) and norantipyrine (NORA) were measured in plasma and urine by high performance liquid chromatography (HPLC). The apparent volume of distribution of antipyrine (aVd) decreased significantly between 1 and 18 months of age, but mean aVd values observed in males and females were not statistically different. The experimental period was characterised by a steady decrease (statistically significant) in antipyrine half-life (t1/2beta). These values did not differ significantly between males and females under 12 months. In 12 and 18 month-old animals the antipyrine half-life in the females was significantly shorter than in the males. The systemic clearance (Cls) of antipyrine increased significantly between 1 and 18 months of age. No significant differences were observed between systemic clearance of antipyrine in males and females under 12 months. In 12 and 18 month-old animals the Cls values were significantly higher in females than in males. Following intravenous administration, recovery of antipyrine and its three main metabolites increased significantly with age. These values did not differ significantly between males and females under 12 month of age. In 12 and 18 month-old females the excretion of 4-OHA and HMA in urine was significantly higher than in males at the same age. The excretion of NORA and unchanged antipyrine in males and females did not differ significantly. The partial clearances of antipyrine metabolites (Cl(m)) increased significantly between 1 and 18 months of age. No significant differences were observed between Cl(m) values in males and females under 12 months of age. In 12 and 18 month-old females the partial clearances of 4-OHA and HMA were significantly higher than in males. The clearance of NORA was significantly higher in 18 month-old females than in males. In conclusion, we report a sex-linked difference in plasma antipyrine clearance and urinary excretion of the main metabolites of antipyrine in cattle over 12 months of age, the females being the more active metabolizers.

show abstract

mentioning

confidence: 99%

The effect of sex on antipyrine metabolism in cattle at different ages

Janus

Antoszek

1999

Vet Pharm & Therapeutics

Self Cite

View full text Add to dashboard Cite

show abstract

Effect of orally administered cimetidine and ranitidine on abomasal luminal pH in clinically normal milk-fed calves

Aljawadi

Constable²,

Misk

2001

ajvr

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The effect of cimetidine on antipyrine metabolism in calves

Cited by 2 publications

References 14 publications

The effect of sex on antipyrine metabolism in cattle at different ages

The effect of sex on antipyrine metabolism in cattle at different ages

Effect of orally administered cimetidine and ranitidine on abomasal luminal pH in clinically normal milk-fed calves

Contact Info

Product

Resources

About