1990
DOI: 10.1002/j.1552-4604.1990.tb03570.x
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The Effect of Ciprofloxacin on the Pharmacokinetic and ECG Parameters of Quinidine

Abstract: Ciprofloxacin decreases the clearance of antipyrine and other drugs which, in part, undergo oxidative metabolism. Based on these findings, the authors hypothesized that ciprofloxacin may decrease the clearance of quinidine, a drug which also undergoes oxidative metabolism. The purpose of this study was to evaluate the effect of ciprofloxacin on the pharmacokinetic and ECG parameters of quinidine in seven healthy men. Oral quinidine sulfate 400 mg was administered alone (Phase A) and after oral ciprofloxacin pr… Show more

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Cited by 6 publications
(4 citation statements)
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“…Fuhr et al (1993) evaluated the effects of 44 quino10nes on in vitro preparations of CYP1A2, and developed a model to predict quinolone inhibition of caffeine 3-demethylation based on structure-activity relationships. In support of the selective inhibition of CYP1A2 by some quinolones, Bleske et al (1990) found that ciprofloxacin did not inhibit the metabolism of quinidine. Since quinidine is metabolised by CYP3A4 (table I), this negative trial is consistent with findings that quinolones do not inhibit the metabolism of drugs that are metabolised primarily by CYP3A4, such as cyclosporin (see above).…”
Section: Methylxanthinesmentioning
confidence: 96%
“…Fuhr et al (1993) evaluated the effects of 44 quino10nes on in vitro preparations of CYP1A2, and developed a model to predict quinolone inhibition of caffeine 3-demethylation based on structure-activity relationships. In support of the selective inhibition of CYP1A2 by some quinolones, Bleske et al (1990) found that ciprofloxacin did not inhibit the metabolism of quinidine. Since quinidine is metabolised by CYP3A4 (table I), this negative trial is consistent with findings that quinolones do not inhibit the metabolism of drugs that are metabolised primarily by CYP3A4, such as cyclosporin (see above).…”
Section: Methylxanthinesmentioning
confidence: 96%
“…Population geometric means are shown as lines, geometric standard deviations are shown as shaded areas, and observed data are shown as dots (training dataset) and triangles (test dataset) (±standard deviation, if reported). 8 , 25 , 26 , 27 , 28 , 29 (g–i) Goodness‐of‐fit plots comparing predicted and observed (g) plasma concentrations, (h) area under the plasma concentration‐time curve calculated between first and last concentration measurement (AUC last ) and (i) maximum plasma concentration ( C max ) values. The solid line represents the line of identity, whereas 1.25‐fold and two‐fold prediction limits are shown as dotted and dashed lines, respectively.…”
Section: Resultsmentioning
confidence: 99%
“…(a-f) Predicted compared to observed plasma concentration-time profiles of quinidine and 3-hydroxyquinidine after (a) intravenous and (b-f) oral administration. Population geometric means are shown as lines, geometric standard deviations are shown as shaded areas, and observed data are shown as dots (training dataset) and triangles (test dataset) (±standard deviation, if reported) 8,[25][26][27][28][29]. (g-i) Goodness-of-fit plots comparing predicted and observed (g) plasma concentrations, (h) area under the plasma concentration-time curve calculated between first and last concentration measurement (AUC last ) and (i) maximum plasma concentration (C max ) values.…”
mentioning
confidence: 99%
“…Several studies showed that different isoforms of cytochrome P450 are responsible for the 1-and 3demethylation and the 8-hydroxylation pathways of methylxanthine metabolism. That the CYP1A2 subclass is selectively inhibited by fluoroquinolones is supported by the fact that no interaction was observed between ciprofloxacin and quinidine (BLESKE et al 1990), ciprofloxacin and cyclosporine (VAN BUREN et al 1990;TAN et al 1989) or ciprofloxacin and clarithromycin (POLK 1993). human microsomes, cell lines) resulted in different associations (HA et al 1995).…”
mentioning
confidence: 99%