The effect of citrate on calcium phosphate deposition from simulated milk ultrafiltrate (SMUF) solution

Rosmaninho, R.; Melo, L. F.

doi:10.1016/j.jfoodeng.2005.02.017

Cited by 44 publications

(27 citation statements)

References 16 publications

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“…In addition, adsorption of citrate group to calcium at the surface of calcium phosphate crystals decreases their dissolution and the number of active growth sites. 23 Generally, impurities are ineffectively adsorbed at high supersaturations, as the surface integration rate is too high. 24 Supersaturation of any precipitating solution should be reduced in order to enhance impurity effectiveness.…”

Section: Introductionmentioning

confidence: 99%

Monetite promoting effect of citric acid on brushite cement setting kinetics

Şahin

Çiftçioğlu

2013

Materials Research Innovations

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Brushite forming calcium phosphate cements receive growing interest in hard tissue scaffold applications due to their high surface area and high bioresorbability. The finer microstructure of monetite, the dehydrated form of brushite, has attracted attention for bone tissue engineering applications. The reduction in brushite content of the b-tricalcium phosphate-monocalcium phosphate monohydrate cement system by selective inhibition of growth upon addition of citric acid to excess setting liquid was investigated. The relaxation period during cement setting was monitored by pH stat titration and free drift runs. Spectrometric analysis revealed that the change in solubility of calcium phosphates upon addition of citric acid caused the inhibition of brushite formation and promotion of monetite precipitation. Dissolution of monetite crystals was insensitive to citrate adsorption despite their lower surface area compared to brushite. Overall brushite/ monetite ratio decreased consistently with increasing citric acid concentration in the of 0?1-0?5M range.

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Section: Introductionmentioning

confidence: 99%

Monetite promoting effect of citric acid on brushite cement setting kinetics

Şahin

Çiftçioğlu

2013

Materials Research Innovations

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“…Simulated milk ultrafiltrate (SMUF), which was first described by Jenness and Koops (1962), is a solution that mimics the ion composition of milk ultrafiltrate. It is the most widely used simplified milk system in milk mineral deposition studies (Andritsos, Yiantsios, & Karabelas, 2002;Rosmaninho & Melo, 2006;Spanos, Patis, Kanellopoulou, Andritsos, & Koutsoukos, 2007). It can also be used as a buffer solution for dispersion of milk proteins or for studying physico-chemical properties of milk proteins, such as heat stability, electrophoretic and ultracentrifugal analyses (Jenness & Koops, 1962).…”

Section: Introductionmentioning

confidence: 99%

“…However, it may not be the one that precipitates first because its precipitation kinetics is slower than that of the other 0308-8146/$ -see front matter Ó 2010 Elsevier Ltd. All rights reserved. doi:10.1016/j.foodchem.2010.03.040 phosphate forms (Rosmaninho & Melo, 2006). The formation of calcium phosphate precipitates depends on environmental conditions such as pH, ionic strength, temperature, molar ratio of Ca/P, presence of other ions (Johnsson & Nancollas, 1992;Schmidt, Both, Visser, Slangen, & Vanrooijen, 1987;Spanos et al, 2007;Van Kemenade & De Bruyn, 1987).…”

Section: Introductionmentioning

confidence: 99%

“…DCPD and OCP are formed in more acidic conditions, whereas HAP is preferentially formed under neutral or basic conditions. In addition, other ions such as magnesium and citrate have been reported to act as inhibitors of HAP crystal growth (Johnsson & Nancollas, 1992;Rosmaninho & Melo, 2006). Instead, the presence of these ions in solution (Johnsson & Nancollas, 1992) may stabilise the DCPD and OCP crystals.…”

Section: Introductionmentioning

confidence: 99%

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Modelling ion composition in simulated milk ultrafiltrate (SMUF). I: Influence of calcium phosphate precipitation

et al. 2010

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“…Hydroxyapatite (HAP) has the lowest solubility product and would, therefore, be expected to precipitate out of solution before the other calcium salts (Marshall & Daufin, 1995). However, some authors have found that when supersaturation levels are high, HAP formation is sometimes preceded by formation of dicalcium phosphate dihydrate (brushite, DCPD) or octacalcium phosphate (OCP) (Rosmaninho & Melo, 2006;Schmidt & Both, 1987;Spanos, Patis, Kanellopoulou, Andritsos, & Koutsoukos, 2007). Rosmaninho and Melo (2006) argue that this is a function of citrate concentration, citing results that show that HAP does become the dominant crystallising salt in simulated milk ultrafiltrate (SMUF) solutions containing citrate.…”

Section: Model Developmentmentioning

confidence: 99%