2024
DOI: 10.3389/fnbeh.2023.1305412
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The effect of CNQX on self-administration: present in nicotine, absent in methamphetamine model

Maria Hrickova,
Petra Amchova,
Jana Ruda-Kucerova

Abstract: ObjectiveAddiction is a chronic disease with limited pharmacological options for intervention. Focusing on reducing glutamate levels in the brain seems to be a promising strategy in addiction treatment research. Our research aimed to evaluate the effects of CNQX, an antagonist that targets AMPA and kainate glutamatergic receptors while also exhibiting affinity for the NMDA receptor, especially by modulating its glycine site. We conducted this assessment on the self-administration of nicotine and methamphetamin… Show more

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