The Effect of Cochinchina momordica Seed Extract on Gastric Acid Secretion and Morphologic Change in Aged Rat Stomach

Jo, Hyun Jin; Kim, Nayoung; Nam, Ryoung Hee; Chang, Hyun; Kim, Joo Hyon; Park, Ji Hyun; Kang, Jung Mook; Lee, Dong Hoon; Jung, Hyun Chae

doi:10.5009/gnl.2013.7.5.560

Cited by 11 publications

(9 citation statements)

References 25 publications

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“…In the present study, we found that continuous administration with PMK-S005 reverse the decrease of age-related gastric acid concentration in 74-week-old rats and PMK5 group was more potent than PMK10 group. However, these effects did not more influential in the 2-year-old rats which are comparable to our previous SK-MS10 data 29. In addition, age-related increment of connective tissue in lamina propria seems to be attenuated in PMK5 group in 74-week and 2-year-old rats but the effect was not that apparent (Fig.…”

Section: Discussionsupporting

confidence: 89%

“…We previously reported that Cochinchina momordica seed extract (SK-MS10) attenuated connective tissue change with age and kept the capacity of acid secretion to that of young age, suggesting that SK-MS10 might be an antiaging agent in the stomach as well as mucoprotective agent 29. In the present study, we found that continuous administration with PMK-S005 reverse the decrease of age-related gastric acid concentration in 74-week-old rats and PMK5 group was more potent than PMK10 group.…”

Section: Discussionmentioning

confidence: 99%

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PMK-S005 Alleviates Age-Related Gastric Acid Secretion, Inflammation, and Oxidative Status in the Rat Stomach

et al. 2016

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Background/AimsThe aim of this study was to evaluate the effect of the synthetic S-allyl-l-cysteine (SAC) PMK-S005 on gastric acid secretion, inflammation, and antioxidant enzymes in aging rats.MethodsThe rats were divided into four groups at 31 weeks of age and were continuously fed a diet containing a vehicle control, PMK-S005 (5 or 10 mg/kg), or lansoprazole (5 mg/kg). Gastric acid secretion and connective tissue thickness of the lamina propria were evaluated at 74 weeks and 2 years of age. Tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and COX-2 levels were measured by using enzyme-linked immunosorbent assays (ELISAs) or Western blot assays. Levels of antioxidant enzymes, including heme oxyganase 1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO-1), were also measured.ResultsAs the rats aged, gastric acid secretion significantly decreased, and the connective tissue of the lamina propria increased. However, 74-week-old rats in the PMK-S005 group exhibited greater levels of gastric acid secretion than those of the control and lansoprazole groups. The increase of TNF-α, IL-1β, and COX-2 expression in 74-week and 2-year-old control rats were inhibited by PMK-S005. In addition, the decrease in HO-1 and NQO-1 protein expression that occurred with aging was inhibited by PMK-S005 in the 74-week-old rats.ConclusionsThese results suggest that PMK-S005 has therapeutic potential as an antiaging agent to ameliorate age-related gastric acid secretion, inflammation, and oxidative stress in the stomach.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

PMK-S005 Alleviates Age-Related Gastric Acid Secretion, Inflammation, and Oxidative Status in the Rat Stomach

et al. 2016

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“…One gram lansoprazole was mixed with 20 kg rat chow to obtain the daily dose. A recent study from our group of the long-term (1.5 years) administration of lansoprazole 5 mg/kg/day found that 74-week old F344 rats in the lansoprazole group had lower stimulated gastric acid secretion than those in the vehicle group 10. In the present study, the rats were fasted but allowed water for 12 hours before the experiments.…”

Section: Methodsmentioning

confidence: 53%

“…Gastric hypochlorhydria in the elderly has been associated with the risk of developing SIBO 15,16. Recently, we evaluated gastric acid secretion in the male F344 rats of four different age groups (6-, 31-, and 74-week, and 2-year) and found that both basal and stimulated gastric acid secretions significantly decreased with increased connective tissue of lamina propria with age 10. Nevertheless, we observed that lansoprazole decreased stimulated gastric acid secretion in 74-week-old F344 rats 10.…”

Section: Discussionmentioning

confidence: 99%

Impact of Long-Term Proton Pump Inhibitor Therapy on Gut Microbiota in F344 Rats: Pilot Study

Shin

Kim

et al. 2016

Gut and Liver

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Background/AimsTo evaluate changes in gut microbiota composition following long-term proton pump inhibitor (PPI) treatment.MethodsTwenty-four-week-old F344 rats were fed diets with (n=6) or without (n=5) lansoprazole for 50 weeks. Profiles of luminal microbiota in the terminal ileum were then analyzed. Pyrosequencing of the 16S rRNA gene was performed using an FLX genome sequencer (454 Life Sciences/Roche).ResultsRats treated with lansoprazole showed significantly reduced body weights compared to controls (lansoprazole-treated rats and controls, 322.3±15.3 g vs 403.2±5.2 g, respectively, p<0.001). However, stool frequencies and consistencies did not differ between the two groups. The composition of the gut microbiota in lansoprazole-treated rats was quite different from that of the controls. In the controls, the microbiota profiles obtained from the terminal ileum showed a predominance of Proteobacteria (93.9%) due to the abundance of Escherichia and Pasteurella genera. Conversely, lansoprazole-treated rats showed an elevated population of Firmicutes (66.9%), which was attributed to an increased ratio of Clostridium g4 to Lactobacillus genera.ConclusionsThis preliminary study suggests that long-term administration of PPI may cause weight loss and changes to the microbiota in the terminal ileum.

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“…Firstly, elevated gastric pH results in the increased bacterial colonization in the stomach 36 . This effect might be more severe in the aged since the gastric acid secretion decreased with age in rats 37 . In addition, chronic PPI treatment may reduce the function of neutrophils that produce reactive oxygen species, through the increase of the basal cytosolic calcium concentrations in the neutrophils 38 .…”

Section: Discussionmentioning

confidence: 99%

Gut microbiota and butyrate level changes associated with the long-term administration of proton pump inhibitors to old rats

Lee

Kim

Nam

et al. 2019

Sci Rep

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The association between adverse effects of PPI and gut microbiota in old age has yet to be elucidated. We assessed changes in the gut microbiota and butyrate levels following the long-term administration of PPIs to old rats and investigated their associations. F344 aged male rats were fed a PPI-supplemented diet for 50 weeks. The ileal microbiota was analysed by metagenomic sequencing of the 16S rRNA, while the butyrate concentration was measured by high-performance liquid chromatography. We observed a significant decrease in microbial diversity following PPI administration in the 2-year-old rats but not in the 74-week-old rats. PPI treatment reduced both commensal bacteria and opportunistic pathogens, particularly in the 2-year-old rats. Enterotypes comprising the majority of the control samples were enriched in Lactobacillus , while other enterotypes in the PPI group were dominated by Turicibacter or Romboutsia . The PPI treatment reduced the butyrate concentrations in the intestines and colons of 74-week-old rats compared to the control group. The abundance of Lactobacillus significantly correlated with butyrate concentrations in 74-week-old rats. In conclusion, long-term administration of PPIs alters the gut microbiota and butyrate concentrations in rats, particularly in old age, which may be an underlying mechanism of PPI-induced adverse effects such as pseudomembranous colitis.

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The Effect of Cochinchina momordica Seed Extract on Gastric Acid Secretion and Morphologic Change in Aged Rat Stomach

Cited by 11 publications

References 25 publications

PMK-S005 Alleviates Age-Related Gastric Acid Secretion, Inflammation, and Oxidative Status in the Rat Stomach

PMK-S005 Alleviates Age-Related Gastric Acid Secretion, Inflammation, and Oxidative Status in the Rat Stomach

Impact of Long-Term Proton Pump Inhibitor Therapy on Gut Microbiota in F344 Rats: Pilot Study

Gut microbiota and butyrate level changes associated with the long-term administration of proton pump inhibitors to old rats

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