By blending heat-cured polymethylmethacrylate (PMMA) resin with two different types of polymers, which are polyamide (PV) type ( 6) and polyvinylpyrrolidone (PVP) type (K30), added separately with various weight fractions (0, 2, 4 and 6%) to heat-cured PMMA resin as blend matrix, attempts have been made in this study for developing the PMMA resin properties employed for prosthesis complete denture. Sisal powder and coconut powder, two different types of natural powders, were added separately to the polymer blend matrices with varying weight fractions (2%, 4%, and 6%) to prepare composite specimens. Hand lay-up methods were used for preparing all specimens. This study covered the flexural test using the 3-point bending method, the impact test using the Izod method, and the maximum shear stress test using the 3-point bending method.According to the results, adding polymer blends and reinforcing powders boosts the impact strength, while lowering flexural modulus, flexural strength, and maximum shear stress. The composite specimens made of (PMMA-2% PVP-6% sisal) manifested the best impact strength and value (11.875 KJ/m 2 ). These findings lead to the conclusion that using PMMA-based biocomposites with polyamide and polyvinylpyrrolidone blends improved impact strength for denture applications, which is one of the most important properties of these applications.