The effect of cognitive training on domains of attention in older adults with mild cognitive impairment and mild dementia: A meta-analysis of randomised controlled trials

Sung, C. L.; Jen, Hsiu‐Ju; Liu, Doresses; Kustanti, Christina Yeni; Chu, Hsin; Chen, Ruey; Lin, Hui-Chen; Chang, Ching-Yi; Chou, Kuei‐Ru

doi:10.7189/jogh.13.04078

Cited by 2 publications

(1 citation statement)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several previous studies have reported that VitD did not affect global cognition, neither improved cognitive functioning on supplementation 13,40,42 . Deficits in attention is a part of aging and it has been found that attention training interventions improved cognitive functioning in individuals with MCI or mild to moderate dementia 57 . VitD deficiency is a well-known biomarker of Attention-Deficit/ Hyperactivity Disorder (ADHD) in children 58 .…”

Section: Discussionmentioning

confidence: 99%

Prevalence and patterns of vitamin D deficiency and its role in cognitive functioning in a cohort from South India

Ghosh,

Sunny

et al. 2024

Sci Rep

View full text Add to dashboard Cite

Vitamin D (VitD) is a naturally occurring, fat-soluble vitamin which regulates calcium and phosphate homeostasis in the human body and is also known to have a neuroprotective role. VitD deficiency has often been associated with impaired cognition and a higher risk of dementia. In this study, we aimed to explore the relationship between levels of VitD and cognitive functioning in adult individuals. 982 cognitively healthy adults (≥ 45 years) were recruited as part of the CBR-Tata Longitudinal Study for Aging (TLSA). Addenbrooke’s cognitive examination-III (ACE-III) and Hindi mental status examination (HMSE) were used to measure cognitive functioning. 25-hydroxyvitamin D [25(OH)D] levels were measured from the collected serum sample and classified into three groups— deficient (< 20 ng/ml), insufficient (20–29 ng/ml) and normal (≥ 30 ng/ml). Statistical analysis was done using IBM SPSS software, version 28.0.1.1(15). The mean age of the participants was 61.24 ± 9 years. Among 982 participants, 572 (58%) were deficient, 224 (23%) insufficient and only 186 (19%) had normal levels of VitD. Kruskal–Wallis H test revealed a significant difference in age (p = 0.015) and education (p = 0.021) across VitD levels and the Chi-square test revealed a significant association between gender (p = 0.001) and dyslipidemia status (p = 0.045) with VitD levels. After adjusting for age, education, gender and dyslipidemia status, GLM revealed that individuals with deficient (p = 0.038) levels of VitD had lower scores in ACE-III verbal fluency as compared to normal. Additionally, we also found that 91.2% individuals who had VitD deficiency were also having dyslipidemia. It is concerning that VitD deficiency impacts lipid metabolism. Lower levels of VitD also negatively impacts verbal fluency in adult individuals. Verbal fluency involves higher order cognitive functions and this result provides us with a scope to further investigate the different domains of cognition in relation to VitD deficiency and other associated disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence and patterns of vitamin D deficiency and its role in cognitive functioning in a cohort from South India

Ghosh,

Sunny

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

Slowing Cognitive Decline in Major Depressive Disorder and Mild Cognitive Impairment

Rajji,

Bowie,

Herrmann

et al. 2024

JAMA Psychiatry

View full text Add to dashboard Cite

ImportanceOlder adults with major depressive disorder (MDD) or mild cognitive impairment (MCI) are at high risk for cognitive decline.ObjectiveTo assess the efficacy of cognitive remediation (CR) plus transcranial direct current stimulation (tDCS) targeting the prefrontal cortex in slowing cognitive decline, acutely improving cognition, and reducing progression to MCI or dementia in older adults with remitted MDD (rMDD), MCI, or both.Design, Setting, and ParticipantsThis randomized clinical trial was conducted at 5 academic hospitals in Toronto, Ontario, Canada. Participants were older adults who had rMDD (with or without MCI, age ≥65 y) or MCI without rMDD (age ≥60 y). Assessments were made at baseline, month 2, and yearly from baseline for 3 to 7 years.InterventionsCR plus tDCS (hereafter, active) or sham plus sham 5 days a week for 8 weeks followed by twice-a-year 5-day boosters and daily at-home CR or sham CR.Main Outcomes and MeasuresThe primary outcome was change in global composite cognitive score. Secondary outcomes included changes in 6 cognitive domains, moderating effect of the diagnosis, moderating effect of APOE ε4 status, change in composite score at month 2, and progression to MCI or dementia over time.ResultsOf 486 older adults who provided consent, 375 (with rMDD, MCI, or both) received at least 1 intervention session (mean [SD] age, 72.2 [6.4] years; 232 women [62%] and 143 men [38%]). Over a median follow-up of 48.3 months (range, 2.1-85.9), CR and tDCS slowed cognitive decline in older adults with rMDD or MCI (adjusted z score difference [active − sham] at month 60, 0.21; 95% CI, 0.07 to 0.35; likelihood ratio test [LRT] P = .006). In the preplanned primary analysis, CR and tDCS did not improve cognition acutely (adjusted z score difference [active − sham] at month 2, 0.06, 95% CI, −0.006 to 0.12). Similarly, the effect of CR and tDCS on delaying progression from normal cognition to MCI or MCI to dementia was weak and not significant (hazard ratio, 0.66; 95% CI, 0.40 to 1.08; P = .10). Preplanned analyses showed treatment effects for executive function (LRT P = .04) and verbal memory (LRT P = .02) and interactions with diagnosis (P = .01) and APOE ε4 (P &lt; .001) demonstrating a larger effect among those with rMDD and in noncarriers of APOE ε4.Conclusions and RelevanceThe study showed that CR and tDCS, both targeting the prefrontal cortex, is efficacious in slowing cognitive decline in older adults at risk of cognitive decline, particularly those with rMDD (with or without MCI) and in those at low genetic risk for Alzheimer disease.Trial RegistrationClinicalTrials.gov Identifier: NCT02386670

show abstract

The effect of cognitive training on domains of attention in older adults with mild cognitive impairment and mild dementia: A meta-analysis of randomised controlled trials

Cited by 2 publications

References 39 publications

Prevalence and patterns of vitamin D deficiency and its role in cognitive functioning in a cohort from South India

Prevalence and patterns of vitamin D deficiency and its role in cognitive functioning in a cohort from South India

Slowing Cognitive Decline in Major Depressive Disorder and Mild Cognitive Impairment

Contact Info

Product

Resources

About