The effect of cold-knife conization on pregnancy outcomes in patients with cervical lesions

Abstract

Objective To analyze the pregnancy outcomes of patients with cervical lesions treated by cold-knife conization (CKC). Methods Clinical data of healthy pregnant women and pregnant women who underwent CKC in Dalian Women and Children’s Medical Group from March 2010 to December 2019 were retrospectively analyzed. These patients were divided into a CKC group and a control group according to inclusion and exclusion criteria. Statistical methods were used to compare pregnancy and delivery outcomes between the two groups. Results There were 400 patients in CKC group and control group, with 200 patients in each. There was no significant difference in the mode of delivery, abortion, ectopic pregnancy, in-hospital perinatal management, and cervical cerclage between the CKC group and the control group (P>0.05). The rates of preterm delivery, premature rupture of membranes, cesarean section, and neonatal admission in the CKC group were higher than those in the control group (P<0.05). In the CKC group, the incidence of premature rupture of membranes within six months postoperatively was higher than that after six months (P<0.05). The incidences of preterm delivery and premature rupture of membranes were not completely consistent in different conization ranges (P<0.05). Conclusion CKC increases the incidence of preterm delivery, premature rupture of membranes, and neonatal adverse outcomes. Conization height can predict the occurrence of preterm delivery. Delaying pregnancy after surgery can reduce the incidence of adverse outcomes during the perinatal period.

LncRNA WWTR1-AS1 upregulates Notch3 through miR-136 to increase cancer cell stemness in cervical squamous cell carcinoma

“…Recent developments in immunotherapy have expanded the possibilities, including the potential for therapeutic vaccines and other tailored treatment strategies in cervical cancers. These advancements contribute to the pursuit of more precise and effective therapies [ 21 ]. The molecular mechanisms unveiled in this study provide insights into the enhancement of CSCC screening and potentially refining treatment approaches.…”

Perinatal complications following excisional treatment of cervical dysplasia

“…The influence of cold knife conization (CKC) of the cervix on women's reproductive performance has been studied since the 1940s (15). Later studies asserted that CKC was associated with numerous perinatal complications (14,17,18,19).…”

3D Printing Cervical Implant Scaffolds Incorporated with Drug-Loaded Carboxylated Chitosan Microspheres for Long-Term Anti-HPV Protein Delivery

“…Resection of the cervical tissue reduced the cervix's load-bearing capacity and weakened the extensibility of the cervix leading for the incidence of premature birth or premature rupture of membranes. 16 Also, a large amount of the remaining virus may cause postoperative reinfection in the lesion. The 3D-printed drug-loaded scaffold adapted to the personalized tissue shape of different patients can provide adaptive mechanical support and prevent residuary virus infection.…”

“…At present, one of the most urgent clinical demands for drug-loaded 3D-printed scaffolds is to patch the defect after the resection treatment of cervical cancer caused by human papillomavirus (HPV). Resection of the cervical tissue reduced the cervix’s load-bearing capacity and weakened the extensibility of the cervix leading for the incidence of premature birth or premature rupture of membranes . Also, a large amount of the remaining virus may cause postoperative reinfection in the lesion.…”