The effect of colorectal cancer upon host peripheral immune cell function

Abstract

Colorectal cancer induces an immunological response, shifting the cytokine balance. The most profound changes are seen once disease has spread systemically.

Clinical Impact of Different Classes of Infiltrating T Cytotoxic and Helper Cells (Th1, Th2, Treg, Th17) in Patients with Colorectal Cancer

“…Previously, Th2 response was associated with the tumor immune evasion in mice studies (24,25), or not associated with clinical outcome in human studies (26,27). Our study does not support a major role of Th2 cells on patient's prognosis.…”

Surgical and not analgesic technique affects postoperative inflammation following colorectal cancer surgery: a prospective, randomized study

“…There is evidence of a role of IL-10 in promoting both tumour progression and inhibition of tumour growth by different mechanisms [13]. IL-10 has even been proposed as a prognostic cancer marker with higher serum levels in advanced disease [14], able to predict worse outcome after surgery for colon cancer [15] as well as an association with worse…”

Epicatechin and scopoletin‐rich Morinda citrifolia leaf ameliorated leukemia via anti‐inflammatory, anti‐angiogenesis, and apoptosis pathways in vitro and in vivo

“…The IL‐10 and IL‐4 encouraged Th0 (naive helper T) cells differentiation to Th2 cells, activating B‐cell and T‐cell proliferation, as well as B cells differentiation into plasma cells, inducing B‐cell class switching to IgE, up‐regulated MHC class II production; and decreased Th1 cells production, macrophages, IFN ‐gamma, and dendritic cell IL‐12. The IL‐10 inhibit proliferation and cytokine secretion of TH1 cells, and stimulate activated B‐cells and TH2 cells humoral immune response which later elevate IgM, IgA, and IgG secretions (Evans et al, ).…”