The effect of colostrum intake on blood plasma proteome profile in newborn lambs: low abundance proteins

Hernández-Castellano, Lorenzo E.; Almeida, André M.; Ventosa, Miguel; Coelho, Ana Varela; Castro, N.; Argüello, A.

doi:10.1186/1746-6148-10-85

Cited by 59 publications

(43 citation statements)

References 60 publications

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“…Dessa forma, os recém-nascidos destas espécies nascem hipo ou agamaglobulinêmicos e sua sobrevivência depende diretamente do consumo de colostro nas primeiras horas de vida [5][6][7][8] . O colostro encontra-se intimamente vinculado aos mecanismos de defesa imunológica e ao aporte de nutrientes para os neonatos, interferindo marcadamente sobre muitas características sanguíneas que serão modificadas com o progresso da idade [9][10][11] . Na espécie ovina, informações sobre a cinética dos parâmetros sanguíneos em animais sadios são escassas, sobretudo em animais jovens.…”

Section: Pre and Post-colostral Dynamics Of Biochemical Parameters Inunclassified

Dinâmica pré e pós-colostral de parâmetros bioquímicos em cordeiros

et al. 2014

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RESUMOO objetivo deste estudo foi verificar a influência do colostro nos parâmetros bioquímicos séricos em cordeiros recém-nascidos. Foram colhidas amostras sanguíneas de 28 cordeiros, determinando-se os indicadores proteicos, energéticos, de função renal, bilirrubinas e as enzimas aspartato aminotransferase (AST), gamaglutamiltransferase (GGT) e creatina quinase (CK), nos momentos pré e pós-colostro. Os dados foram analisados comparando-se a variabilidade dos parâmetros entre os dois momentos. Houve elevação (P<0,001) das concentrações de proteínas totais, em resposta ao forte aumento (P<0,01) dos teores de globulinas totais e ao leve decréscimo (P<0,05) da concentração de albumina, após a ingestão colostral. Também foram observados maiores valores de bilirrubinas total e direta (P<0,001), e variação dos metabólitos renais, com elevação dos níveis de ureia (P<0,01) concomitante à redução dos valores de creatinina (P<0,001), no momento pós-colostro. Houve aumento (P<0,001) da glicemia, de colesterol total e triglicerídeos, bem como das atividades enzimáticas (P<0,001) de AST e GGT, entre os momentos avaliados. Conclui-se que a dinâmica do perfil bioquímico em cordeiros recém-nascidos sofre o efeito da ingestão de colostro e da adaptação das funções fisiológicas à vida extra-uterina. Os valores dos parâmetros variam marcadamente no período pós-natal, sendo recomendável a utilização de valores de referência próprios para esta fase. PALAVRAS-CHAVE: amamentação, bioquímica clínica, neonato, ovino, sangue. PRE AND POST-COLOSTRAL DYNAMICS OF BIOCHEMICAL PARAMETERS IN LAMBS ABSTRACTThis study aimed to verify the influence of colostrum in serum biochemical parameters in newborn lambs. Blood samples were taken of 28 lambs, determining the protein, energy and kidney function indicators, bilirrubins and the enzymes aspartate aminotransferase (AST), gammaglutamyl transferase (GGT) and creatine kinase (CK), in pre and post-colostrum moments. The data were analyzed comparing the variability of the parameters between the two moments. There was an elevation (P<0.001) in total protein concentrations, in response to substantial increase (P<0.01) in total globulin levels, and a slight decrease (P<0.05) in albumin concentration, after colostral intake. We also observed higher values of total and conjugated bilirubins (P<0.001), and variation of kidney metabolites, with an elevation of urea levels (P<0.01) concomitant to decrease of creatinine values (P<0.001) in the postcolostrum moment. There was an increase (P<0.001) in glycemia, total cholesterol and triglycerides, as well as of

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Section: Pre and Post-colostral Dynamics Of Biochemical Parameters Inunclassified

Dinâmica pré e pós-colostral de parâmetros bioquímicos em cordeiros

et al. 2014

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“…Timing of the first colostrum feeding (TFCF) is another important factor that affects immune status and, therefore, the future productivity of adult animals (Hernández-Castellano et al, 2014b). For ruminants, the period between 12 and 36 h after birth is critical for absorption of colostrum IgG (Chen et al, 1999;Nowak and Poindron, 2006;Castro-Alonso et al, 2008) to acquire an adequate initial immunoglobulin concentration in blood (O'Doherty and Crosby, 1997;Quigley et al, 2000;Christley et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

The effect of colostrum source (goat vs. sheep) and timing of the first colostrum feeding (2 h vs. 14 h after birth) on body weight and immune status of artificially reared newborn lambs

Hernández-Castellano

Morales-delaNuez

Sánchez-Macías

et al. 2015

Journal of Dairy Science

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Several factors can affect lamb body weight (BW) and immune status during the first days of life, including colostrum source and timing of the first colostrum feeding. The aim of this study was to evaluate the effects of colostrum source (goat or sheep) and timing of the first colostrum feeding (2 or 14 h after birth) on lamb BW and immune status. In this study, 40 lambs were removed from their dams at birth and randomly assigned into 4 groups of 10 lambs each. Lambs were subsequently fed at 2 or 14 h after birth with goat or sheep colostrum. Blood samples and BW recording were performed before feeding. Blood plasma was used to measure the immunoglobulin concentration (IgG and IgM), chitotriosidase activity, and complement system activity (total and alternative pathways). In general, no differences in any of the measured variables were observed among the 4 groups, indicating that neither colostrum source nor timing of the first colostrum feeding had an effect on these variables. These findings may improve management on lamb farms that raise animals under artificial conditions, because our results indicate that it is not necessary to feed colostrum to lambs immediately after birth and that goat colostrum may be used to feed newborn lambs.

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“…The colostral IgG levels are lower in preterm births. Hormonal alterations following IP may negatively affect the colostral IgG level (10,11,23). IP with 10, 17.5 and 25 mg doses of dexamethasone at the 142nd-145th days of gestation causes a decrease in the colostral IgG levels in ewes (15).…”

Section: Discussionmentioning

confidence: 99%

Comparison of the endocrinological and immunological results of different induction of parturition methods in ewes

Salci¹,

Demirbilek²,

Güneş³

et al. 2018

Tierarztl Prax Ausg G

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SummaryObjective: This study aimed to compare different induction of parturition (IP) methods in terms of endocrinological and immunological parameters in ewes and lambs. Materials and methods: A total of 24 ewes and their respective 24 lambs were studied. Groups of six ewes were induced on the 138th day: groups I (control), II (dexamethasone), III (aglepristone) and IV (aglepristone + dexamethasone). Blood samples were taken from the ewes from IP to 2 days postpartum at 12-hour intervals for the prolactin and oxytocin analyses. Colostrum and blood samples were collected from the lambs at 0, 12, 24, 36 and 48 hours for the IgG analysis. The prolactin, oxytocin and IgG levels were measured by ELISA. Results: A significant difference was found in prolactin levels in all groups and in the colostral IgG level in group IV with respect to the sampling time. Additionally, a significant difference in prolactin level was found at 24 hours postpartum between group IV and groups I and III. A significant difference in the colostral IgG level was determined at 24 hours after parturition between group III and the other groups and at 48 hours after parturition between groups II and III. A positive and significant correlation between the colostral and serum IgG levels of the lambs was found at 24 hours in groups I and II. Conclusion and clinical relevance: Although varying individual results were found within the groups, the endocrinological and immunological results did not suggest any superiority among the IP methods. Considering the presented study results, a single dose of aglepristone may be used alone or in combination with dexamethasone for IP.

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The effect of colostrum intake on blood plasma proteome profile in newborn lambs: low abundance proteins

Cited by 59 publications

References 60 publications

Dinâmica pré e pós-colostral de parâmetros bioquímicos em cordeiros

Dinâmica pré e pós-colostral de parâmetros bioquímicos em cordeiros

The effect of colostrum source (goat vs. sheep) and timing of the first colostrum feeding (2 h vs. 14 h after birth) on body weight and immune status of artificially reared newborn lambs

Comparison of the endocrinological and immunological results of different induction of parturition methods in ewes

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